{"metadata":{"accession":"PF05276","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR007940","hierarchy":null,"name":{"name":"SH3 domain-binding protein 5 (SH3BP5)","short":"SH3BP5"},"description":[{"text":"<p>This family consists of several eukaryotic SH3 domain-binding protein 5 or c-Jun N-terminal kinase (JNK)-interacting proteins (SH3BP5 or Sab). Sab binds to and serves as a substrate for JNK in vitro, and has been found to interact with the Src homology 3 (SH3) domain of Bruton's tyrosine kinase (Btk).  Inspection of the sequence of Sab reveals the presence of two putative mitogen-activated protein kinase interaction motifs (KIMs) similar to that found in the JNK docking domain of the c-Jun transcription factor, and four potential serine-proline JNK phosphorylation sites in the C-terminal half of the molecule [[cite:PUB00010453]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00010453":{"PMID":12167088,"ISBN":null,"volume":"367","issue":"Pt 3","year":2002,"title":"A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria.","URL":null,"raw_pages":"577-85","medline_journal":"Biochem J","ISO_journal":"Biochem. J.","authors":["Wiltshire C","Matsushita M","Tsukada S","Gillespie DA","May GH."],"DOI_URL":"http://dx.doi.org/10.1042/BJ20020553"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":58,"interactions":0,"matches":3849,"pathways":0,"proteins":3719,"proteomes":1250,"sets":0,"structural_models":{"alphafold":3395,"bfvd":0},"structures":5,"taxa":4284},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":18,"alignment:full":2529},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}