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{
    "metadata": {
        "accession": "PF00790",
        "entry_id": null,
        "type": "repeat",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR002014",
        "hierarchy": null,
        "name": {
            "name": "VHS domain",
            "short": "VHS"
        },
        "description": [
            {
                "text": "<p>Domain present in VPS-27, Hrs and STAM.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": [
            {
                "title": "VHS_protein_domain",
                "extract": "<p>In molecular biology, the <b>VHS</b> <b>protein domain</b> is approximately 140 residues long. Its name is an acronym derived from its occurrence in <b>V</b>PS-27, <b>H</b>rs and <b>S</b>TAM. It is a domain commonly found in the N-terminus of many proteins.</p>",
                "thumbnail": null
            }
        ],
        "literature": {
            "PUB00018178": {
                "PMID": 9872381,
                "ISBN": null,
                "volume": "440",
                "issue": "3",
                "year": 1998,
                "title": "VHS domain marks a group of proteins involved in endocytosis and vesicular trafficking.",
                "URL": null,
                "raw_pages": "255-7",
                "medline_journal": "FEBS Lett",
                "ISO_journal": "FEBS Lett.",
                "authors": [
                    "Lohi O",
                    "Lehto VP."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/S0014-5793(98)01401-X"
            },
            "PUB00008038": {
                "PMID": 10693761,
                "ISBN": null,
                "volume": "100",
                "issue": "4",
                "year": 2000,
                "title": "Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction.",
                "URL": null,
                "raw_pages": "447-56",
                "medline_journal": "Cell",
                "ISO_journal": "Cell",
                "authors": [
                    "Mao Y",
                    "Nickitenko A",
                    "Duan X",
                    "Lloyd TE",
                    "Wu MN",
                    "Bellen H",
                    "Quiocho FA."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/S0092-8674(00)80680-7"
            }
        },
        "set_info": {
            "accession": "CL0020",
            "name": "TPR"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 380,
            "interactions": 0,
            "matches": 29692,
            "pathways": 0,
            "proteins": 29574,
            "proteomes": 3252,
            "sets": 1,
            "structural_models": {
                "alphafold": 26764,
                "bfvd": 0
            },
            "structures": 23,
            "taxa": 9106
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 15,
            "alignment:full": 20222
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "1ujk",
            "name": "VHS domain of human GGA1 complexed with C-terminal phosphopeptide from BACE"
        }
    }
}