{"metadata":{"accession":"PF00790","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002014","hierarchy":null,"name":{"name":"VHS domain","short":"VHS"},"description":[{"text":"<p>Domain present in VPS-27, Hrs and STAM.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"VHS_protein_domain","extract":"<p>In molecular biology, the <b>VHS</b> <b>protein domain</b> is approximately 140 residues long. Its name is an acronym derived from its occurrence in <b>V</b>PS-27, <b>H</b>rs and <b>S</b>TAM. It is a domain commonly found in the N-terminus of many proteins.</p>","thumbnail":null}],"literature":{"PUB00018178":{"PMID":9872381,"ISBN":null,"volume":"440","issue":"3","year":1998,"title":"VHS domain marks a group of proteins involved in endocytosis and vesicular trafficking.","URL":null,"raw_pages":"255-7","medline_journal":"FEBS Lett","ISO_journal":"FEBS Lett.","authors":["Lohi O","Lehto VP."],"DOI_URL":"http://dx.doi.org/10.1016/S0014-5793(98)01401-X"},"PUB00008038":{"PMID":10693761,"ISBN":null,"volume":"100","issue":"4","year":2000,"title":"Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction.","URL":null,"raw_pages":"447-56","medline_journal":"Cell","ISO_journal":"Cell","authors":["Mao Y","Nickitenko A","Duan X","Lloyd TE","Wu MN","Bellen H","Quiocho FA."],"DOI_URL":"http://dx.doi.org/10.1016/S0092-8674(00)80680-7"}},"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":380,"interactions":0,"matches":29692,"pathways":0,"proteins":29574,"proteomes":3252,"sets":1,"structural_models":{"alphafold":26764,"bfvd":0},"structures":23,"taxa":9106},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":15,"alignment:full":20222},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1ujk","name":"VHS domain of human GGA1 complexed with C-terminal phosphopeptide from BACE"}}}