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{
    "metadata": {
        "accession": "PF00636",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "pfam",
        "member_databases": null,
        "integrated": "IPR000999",
        "hierarchy": null,
        "name": {
            "name": "Ribonuclease III domain",
            "short": "Ribonuclease_3"
        },
        "description": null,
        "wikipedia": [
            {
                "title": "Ribonuclease_III",
                "extract": "<p><b>Ribonuclease III (RNase III or RNase C)</b> (BRENDA <span class=\"external text\">3.1.26.3</span>) is a type of ribonuclease that recognizes dsRNA and cleaves it at specific targeted locations to transform them into mature RNAs. These enzymes are a group of endoribonucleases that are characterized by their ribonuclease domain, which is labelled the RNase III domain. They are ubiquitous compounds in the cell and play a major role in pathways such as RNA precursor synthesis, RNA Silencing, and the <i>pnp</i> autoregulatory mechanism.</p>",
                "thumbnail": null
            }
        ],
        "literature": null,
        "set_info": {
            "accession": "CL0539",
            "name": "RNase_III"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 681,
            "interactions": 0,
            "matches": 34351,
            "pathways": 0,
            "proteins": 24690,
            "proteomes": 6759,
            "sets": 1,
            "structural_models": {
                "alphafold": 12707,
                "bfvd": 23
            },
            "structures": 64,
            "taxa": 16022
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0,
            "alignment:seed": 221,
            "alignment:full": 19810
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "2eb1",
            "name": "Crystal Structure of the C-Terminal RNase III Domain of Human Dicer"
        }
    }
}