{"metadata":{"accession":"PF00636","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR000999","hierarchy":null,"name":{"name":"Ribonuclease III domain","short":"Ribonuclease_3"},"description":null,"wikipedia":[{"title":"Ribonuclease_III","extract":"<p><b>Ribonuclease III (RNase III or RNase C)</b> (BRENDA <span class=\"external text\">3.1.26.3</span>) is a type of ribonuclease that recognizes dsRNA and cleaves it at specific targeted locations to transform them into mature RNAs. These enzymes are a group of endoribonucleases that are characterized by their ribonuclease domain, which is labelled the RNase III domain. They are ubiquitous compounds in the cell and play a major role in pathways such as RNA precursor synthesis, RNA Silencing, and the <i>pnp</i> autoregulatory mechanism.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0539","name":"RNase_III"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":681,"interactions":0,"matches":34351,"pathways":0,"proteins":24690,"proteomes":6759,"sets":1,"structural_models":{"alphafold":12707,"bfvd":23},"structures":64,"taxa":16022},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":221,"alignment:full":19810},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2eb1","name":"Crystal Structure of the C-Terminal RNase III Domain of Human Dicer"}}}