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{
    "metadata": {
        "accession": "cd22293",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "cdd",
        "member_databases": null,
        "integrated": null,
        "hierarchy": null,
        "name": {
            "name": "N-terminal REV7-binding domain of Shieldin complex subunit 3 (SHLD3) and similar proteins",
            "short": "RBD_SHLD3_N"
        },
        "description": [
            {
                "text": "<p>SHLD3, also called REV7-interacting novel NHEJ regulator 1, or Shield complex subunit 3, is a component of the shieldin complex, which plays an important role in the repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. SHLD3 mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. The model corresponds to the N-terminal REV7-binding domain of SHLD3, which contains a REV7-binding FXPWFP motif. [[cite:PUB00089626], [cite:PUB00147810]]</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00147810": {
                "PMID": 32332881,
                "ISBN": null,
                "volume": "11",
                "issue": "1",
                "year": 2020,
                "title": "Molecular basis for assembly of the shieldin complex and its implications for NHEJ.",
                "URL": null,
                "raw_pages": "1972",
                "medline_journal": "Nat Commun",
                "ISO_journal": "Nat Commun",
                "authors": [
                    "Liang L",
                    "Feng J",
                    "Zuo P",
                    "Yang J",
                    "Lu Y",
                    "Yin Y."
                ],
                "DOI_URL": null
            },
            "PUB00089626": {
                "PMID": 29656893,
                "ISBN": null,
                "volume": "173",
                "issue": "4",
                "year": 2018,
                "title": "DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.",
                "URL": null,
                "raw_pages": "972-988.e23",
                "medline_journal": "Cell",
                "ISO_journal": "Cell",
                "authors": [
                    "Gupta R",
                    "Somyajit K",
                    "Narita T",
                    "Maskey E",
                    "Stanlie A",
                    "Kremer M",
                    "Typas D",
                    "Lammers M",
                    "Mailand N",
                    "Nussenzweig A",
                    "Lukas J",
                    "Choudhary C."
                ],
                "DOI_URL": "https://doi.org/10.1016/j.cell.2018.03.050"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 530,
            "pathways": 0,
            "proteins": 530,
            "proteomes": 469,
            "sets": 0,
            "structural_models": {
                "alphafold": 502,
                "bfvd": 0
            },
            "structures": 3,
            "taxa": 1568
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}