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{
"metadata": {
"accession": "cd18393",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": "IPR047825",
"hierarchy": null,
"name": {
"name": "BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1)",
"short": "BTB_POZ_SHKBP1"
},
"description": [
{
"text": "<p>SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. [[cite:PUB00139493], [cite:PUB00139494], [cite:PUB00139495]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00139495": {
"PMID": 11152963,
"ISBN": null,
"volume": "12",
"issue": "11-12",
"year": 2000,
"title": "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins.",
"URL": null,
"raw_pages": "769-79",
"medline_journal": "Cell Signal",
"ISO_journal": "Cell Signal",
"authors": [
"Borinstein SC",
"Hyatt MA",
"Sykes VW",
"Straub RE",
"Lipkowitz S",
"Boulter J",
"Bogler O."
],
"DOI_URL": null
},
"PUB00139494": {
"PMID": 21830225,
"ISBN": null,
"volume": "29",
"issue": "7",
"year": 2011,
"title": "SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex.",
"URL": null,
"raw_pages": "589-96",
"medline_journal": "Cell Biochem Funct",
"ISO_journal": "Cell Biochem Funct",
"authors": [
"Feng L",
"Wang JT",
"Jin H",
"Qian K",
"Geng JG."
],
"DOI_URL": null
},
"PUB00139493": {
"PMID": 16733801,
"ISBN": null,
"volume": "292",
"issue": "1-2",
"year": 2006,
"title": "Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells.",
"URL": null,
"raw_pages": "189-95",
"medline_journal": "Mol Cell Biochem",
"ISO_journal": "Mol Cell Biochem",
"authors": [
"Liu JP",
"Liu NS",
"Yuan HY",
"Guo Q",
"Lu H",
"Li YY."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl38908",
"name": "BTB_POZ"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 933,
"pathways": 0,
"proteins": 933,
"proteomes": 391,
"sets": 1,
"structural_models": {
"alphafold": 837,
"bfvd": 0
},
"structures": 1,
"taxa": 1378
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "4crh",
"name": "Crystal structure of the BTB-T1 domain of human SHKBP1"
}
}
}
