"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"cd18393"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 933, 'pathways': 0, 'proteins': 933, 'proteomes': 391, 'sets': 1, 'structural_models': {'alphafold': 837, 'bfvd': 0}, 'structures': 1, 'taxa': 1378}"	"{}"	"[{'text': '<p>SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. [[cite:PUB00139493], [cite:PUB00139494], [cite:PUB00139495]]</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	"IPR047825"	False	False	False	"{'PUB00139495': {'PMID': 11152963, 'ISBN': None, 'volume': '12', 'issue': '11-12', 'year': 2000, 'title': 'SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins.', 'URL': None, 'raw_pages': '769-79', 'medline_journal': 'Cell Signal', 'ISO_journal': 'Cell Signal', 'authors': ['Borinstein SC', 'Hyatt MA', 'Sykes VW', 'Straub RE', 'Lipkowitz S', 'Boulter J', 'Bogler O.'], 'DOI_URL': None}, 'PUB00139494': {'PMID': 21830225, 'ISBN': None, 'volume': '29', 'issue': '7', 'year': 2011, 'title': 'SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex.', 'URL': None, 'raw_pages': '589-96', 'medline_journal': 'Cell Biochem Funct', 'ISO_journal': 'Cell Biochem Funct', 'authors': ['Feng L', 'Wang JT', 'Jin H', 'Qian K', 'Geng JG.'], 'DOI_URL': None}, 'PUB00139493': {'PMID': 16733801, 'ISBN': None, 'volume': '292', 'issue': '1-2', 'year': 2006, 'title': 'Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells.', 'URL': None, 'raw_pages': '189-95', 'medline_journal': 'Mol Cell Biochem', 'ISO_journal': 'Mol Cell Biochem', 'authors': ['Liu JP', 'Liu NS', 'Yuan HY', 'Guo Q', 'Lu H', 'Li YY.'], 'DOI_URL': None}}"	""	"{'name': 'BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1)', 'short': 'BTB_POZ_SHKBP1'}"	""	"{'accession': '4crh', 'name': 'Crystal structure of the BTB-T1 domain of human SHKBP1'}"	"{'accession': 'cl38908', 'name': 'BTB_POZ'}"	"cdd"	"domain"	""