HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept
{
"metadata": {
"accession": "cd16779",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "Modified RING finger, HC subclass (C3HC3D-type), found in ligand of numb protein X 1 (LNX1)",
"short": "mRING-HC-C3HC3D_LNX1"
},
"description": [
{
"text": "<p>LNX1, also known as numb-binding protein 1 or PDZ domain-containing RING finger protein 2, is a PDZ domain-containing RING-type E3 ubiquitin ligase responsible for the ubiquitination and degradation of Numb, a component of the Notch signaling pathway that functions in the specification of cell fates during development and is known to control cell numbers during neurogenesis in vertebrates. LNX1 contains an N-terminal modified C3HC3D-type RING-HC finger, a NPAY motif for Numb-LNX interaction, and four PDZ domains necessary for the binding of substrates, including CAR, ErbB2, SKIP, JAM4, CAST, c-Src, Claudins, RhoC, KCNA4, PAK6, PLEKHG5, PKC-alpha1, TYK2, PDZ-binding kinase (PBK), LNX2, and itself. [[cite:PUB00136505], [cite:PUB00136506], [cite:PUB00136507], [cite:PUB00033494]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00136505": {
"PMID": 25200495,
"ISBN": null,
"volume": "552",
"issue": "1",
"year": 2014,
"title": "Tight, cell type-specific control of LNX expression in the nervous system, at the level of transcription, translation and protein stability.",
"URL": null,
"raw_pages": "39-50",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Lenihan JA",
"Saha O",
"Mansfield LM",
"Young PW."
],
"DOI_URL": null
},
"PUB00033494": {
"PMID": 16002321,
"ISBN": null,
"volume": "37",
"issue": "11",
"year": 2005,
"title": "Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas.",
"URL": null,
"raw_pages": "2273-83",
"medline_journal": "Int J Biochem Cell Biol",
"ISO_journal": "Int. J. Biochem. Cell Biol.",
"authors": [
"Chen J",
"Xu J",
"Zhao W",
"Hu G",
"Cheng H",
"Kang Y",
"Xie Y",
"Lu Y."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.biocel.2005.02.028"
},
"PUB00136506": {
"PMID": 22889411,
"ISBN": null,
"volume": "11",
"issue": "10",
"year": 2012,
"title": "Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase.",
"URL": null,
"raw_pages": "4847-62",
"medline_journal": "J Proteome Res",
"ISO_journal": "J Proteome Res",
"authors": [
"Guo Z",
"Song E",
"Ma S",
"Wang X",
"Gao S",
"Shao C",
"Hu S",
"Jia L",
"Tian R",
"Xu T",
"Gao Y."
],
"DOI_URL": null
},
"PUB00136507": {
"PMID": 21827680,
"ISBN": null,
"volume": "11",
"issue": null,
"year": 2011,
"title": "Molecular evolution of the LNX gene family.",
"URL": null,
"raw_pages": "235",
"medline_journal": "BMC Evol Biol",
"ISO_journal": "BMC Evol Biol",
"authors": [
"Flynn M",
"Saha O",
"Young P."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl17238",
"name": "RING_Ubox"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 518,
"pathways": 0,
"proteins": 518,
"proteomes": 274,
"sets": 1,
"structural_models": {
"alphafold": 465,
"bfvd": 0
},
"structures": 2,
"taxa": 1001
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
