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{
"metadata": {
"accession": "cd15894",
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"type": "domain",
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"source_database": "cdd",
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"integrated": "IPR039077",
"hierarchy": null,
"name": {
"name": "N-terminal SNARE motif of SNAP25",
"short": "SNARE_SNAP25N"
},
"description": [
{
"text": "<p>N-terminal SNARE motifs of SNAP25, a member of the Qb/Qc subfamily of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins. SNAP25 interacts with Syntaxin-1 (Qa) and the R-SNARE VAMP2 (also called synaptobrevin-2). The complex plays a role in transport of secretory granule from trans-Golgi network to the plasma membrane. Qb/Qc SNAREs consist of 2 coiled-coil helices (called SNARE motifs, one belonging to the Qb subgroup and one belonging to the Qc subgroup), which mediate the interactions with other SNARE proteins, and a transmembrane domain. In general, the SNARE complex mediates membrane fusion, important for trafficking of newly synthesized proteins, recycling of pre-existing proteins and organelle formation. SNARE proteins are classified into four groups, Qa-, Qb-, Qc- and R-SNAREs, depending on whether the residue in the hydrophilic center layer of the four-helical bundle is a glutamine (Q) or arginine (R). Qa-, as well as Qb- and Qc-SNAREs, are localized to target organelle membranes, while R-SNARE is localized to vesicle membranes. They form unique complexes consisting of one member of each subgroup, that mediate fusion between a specific type of vesicles and their target organelle. Their SNARE motifs form twisted and parallel heterotetrameric helix bundles. Other members of the Qb/Qc SNAREs are SNAP23, SNAP29, SNAP47 and SEC9. [[cite:PUB00113725], [cite:PUB00018360], [cite:PUB00032793], [cite:PUB00113733], [cite:PUB00020397], [cite:PUB00113734], [cite:PUB00113735], [cite:PUB00134567], [cite:PUB00134568], [cite:PUB00133837]]</p>",
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"PUB00113735": {
"PMID": 11718851,
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"volume": "24",
"issue": "12",
"year": 2001,
"title": "SNAREs take the stage: a prime time to trigger neurotransmitter secretion.",
"URL": null,
"raw_pages": "678-80",
"medline_journal": "Trends Neurosci",
"ISO_journal": "Trends Neurosci",
"authors": [
"Bajjalieh S."
],
"DOI_URL": null
},
"PUB00133837": {
"PMID": 17060155,
"ISBN": null,
"volume": "23",
"issue": "5",
"year": 2006,
"title": "SNAREs in neurons--beyond synaptic vesicle exocytosis (Review).",
"URL": null,
"raw_pages": "377-84",
"medline_journal": "Mol Membr Biol",
"ISO_journal": "Mol Membr Biol",
"authors": [
"Wang Y",
"Tang BL."
],
"DOI_URL": null
},
"PUB00020397": {
"PMID": 11737951,
"ISBN": null,
"volume": "2",
"issue": "11",
"year": 2001,
"title": "The syntaxins.",
"URL": null,
"raw_pages": "REVIEWS3012",
"medline_journal": "Genome Biol",
"ISO_journal": "Genome Biol.",
"authors": [
"Teng FY",
"Wang Y",
"Tang BL."
],
"DOI_URL": "http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=11737951"
},
"PUB00032793": {
"PMID": 9731768,
"ISBN": null,
"volume": "5",
"issue": "9",
"year": 1998,
"title": "The synaptic SNARE complex is a parallel four-stranded helical bundle.",
"URL": null,
"raw_pages": "765-9",
"medline_journal": "Nat Struct Biol",
"ISO_journal": "Nat. Struct. Biol.",
"authors": [
"Poirier MA",
"Xiao W",
"Macosko JC",
"Chan C",
"Shin YK",
"Bennett MK."
],
"DOI_URL": "http://dx.doi.org/10.1038/1799"
},
"PUB00018360": {
"PMID": 9861047,
"ISBN": null,
"volume": "95",
"issue": "26",
"year": 1998,
"title": "Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs.",
"URL": null,
"raw_pages": "15781-6",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Fasshauer D",
"Sutton RB",
"Brunger AT",
"Jahn R."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.95.26.15781"
},
"PUB00113733": {
"PMID": 11252968,
"ISBN": null,
"volume": "2",
"issue": "2",
"year": 2001,
"title": "SNARE-mediated membrane fusion.",
"URL": null,
"raw_pages": "98-106",
"medline_journal": "Nat Rev Mol Cell Biol",
"ISO_journal": "Nat Rev Mol Cell Biol",
"authors": [
"Chen YA",
"Scheller RH."
],
"DOI_URL": null
},
"PUB00134568": {
"PMID": 23073634,
"ISBN": null,
"volume": "92",
"issue": "4",
"year": 2012,
"title": "Distinct initial SNARE configurations underlying the diversity of exocytosis.",
"URL": null,
"raw_pages": "1915-64",
"medline_journal": "Physiol Rev",
"ISO_journal": "Physiol Rev",
"authors": [
"Kasai H",
"Takahashi N",
"Tokumaru H."
],
"DOI_URL": null
},
"PUB00134567": {
"PMID": 24274740,
"ISBN": null,
"volume": "76",
"issue": null,
"year": 2014,
"title": "Exocytosis and endocytosis: modes, functions, and coupling mechanisms.",
"URL": null,
"raw_pages": "301-31",
"medline_journal": "Annu Rev Physiol",
"ISO_journal": "Annu Rev Physiol",
"authors": [
"Wu LG",
"Hamid E",
"Shin W",
"Chiang HC."
],
"DOI_URL": null
},
"PUB00113734": {
"PMID": 11066058,
"ISBN": null,
"volume": "57",
"issue": "4",
"year": 2000,
"title": "Fusion of membranes during the acrosome reaction: a tale of two SNAREs.",
"URL": null,
"raw_pages": "309-10",
"medline_journal": "Mol Reprod Dev",
"ISO_journal": "Mol Reprod Dev",
"authors": [
"Kierszenbaum AL."
],
"DOI_URL": null
},
"PUB00113725": {
"PMID": 9635186,
"ISBN": null,
"volume": "8",
"issue": "11",
"year": 1998,
"title": "Membrane fusion: all done with SNAREpins?",
"URL": null,
"raw_pages": "R390-3",
"medline_journal": "Curr Biol",
"ISO_journal": "Curr Biol",
"authors": [
"Edwardson JM."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl22856",
"name": "SNARE"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
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"matches": 1055,
"pathways": 0,
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"sets": 1,
"structural_models": {
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"bfvd": 0
},
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"taxa": 1396
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"representative_structure": {
"accession": "5w5c",
"name": "Crystal structure of the primed SNARE-Complexin-Synaptotagmin-1 C2AB complex"
}
}
}
