"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"cd15894"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 1055, 'pathways': 0, 'proteins': 1055, 'proteomes': 380, 'sets': 1, 'structural_models': {'alphafold': 987, 'bfvd': 0}, 'structures': 50, 'taxa': 1396}"	"{}"	"[{'text': '<p>N-terminal SNARE motifs of SNAP25, a member of the Qb/Qc subfamily of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins. SNAP25 interacts with Syntaxin-1 (Qa) and the R-SNARE VAMP2 (also called synaptobrevin-2). The complex plays a role in transport of secretory granule from trans-Golgi network to the plasma membrane. Qb/Qc SNAREs consist of 2 coiled-coil helices (called SNARE motifs, one belonging to the Qb subgroup and one belonging to the Qc subgroup), which mediate the interactions with other SNARE proteins, and a transmembrane domain. In general, the SNARE complex mediates membrane fusion, important for trafficking of newly synthesized proteins, recycling of pre-existing proteins and organelle formation. SNARE proteins are classified into four groups, Qa-, Qb-, Qc- and R-SNAREs, depending on whether the residue in the hydrophilic center layer of the four-helical bundle is a glutamine (Q) or arginine (R). Qa-, as well as Qb- and Qc-SNAREs, are localized to target organelle membranes, while R-SNARE is localized to vesicle membranes. They form unique complexes consisting of one member of each subgroup, that mediate fusion between a specific type of vesicles and their target organelle. Their SNARE motifs form twisted and parallel heterotetrameric helix bundles. Other members of the Qb/Qc SNAREs are SNAP23, SNAP29, SNAP47 and SEC9. [[cite:PUB00113725], [cite:PUB00018360], [cite:PUB00032793], [cite:PUB00113733], [cite:PUB00020397], [cite:PUB00113734], [cite:PUB00113735], [cite:PUB00134567], [cite:PUB00134568], [cite:PUB00133837]]</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	"IPR039077"	False	False	False	"{'PUB00113735': {'PMID': 11718851, 'ISBN': None, 'volume': '24', 'issue': '12', 'year': 2001, 'title': 'SNAREs take the stage: a prime time to trigger neurotransmitter secretion.', 'URL': None, 'raw_pages': '678-80', 'medline_journal': 'Trends Neurosci', 'ISO_journal': 'Trends Neurosci', 'authors': ['Bajjalieh S.'], 'DOI_URL': None}, 'PUB00133837': {'PMID': 17060155, 'ISBN': None, 'volume': '23', 'issue': '5', 'year': 2006, 'title': 'SNAREs in neurons--beyond synaptic vesicle exocytosis (Review).', 'URL': None, 'raw_pages': '377-84', 'medline_journal': 'Mol Membr Biol', 'ISO_journal': 'Mol Membr Biol', 'authors': ['Wang Y', 'Tang BL.'], 'DOI_URL': None}, 'PUB00020397': {'PMID': 11737951, 'ISBN': None, 'volume': '2', 'issue': '11', 'year': 2001, 'title': 'The syntaxins.', 'URL': None, 'raw_pages': 'REVIEWS3012', 'medline_journal': 'Genome Biol', 'ISO_journal': 'Genome Biol.', 'authors': ['Teng FY', 'Wang Y', 'Tang BL.'], 'DOI_URL': 'http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=11737951'}, 'PUB00032793': {'PMID': 9731768, 'ISBN': None, 'volume': '5', 'issue': '9', 'year': 1998, 'title': 'The synaptic SNARE complex is a parallel four-stranded helical bundle.', 'URL': None, 'raw_pages': '765-9', 'medline_journal': 'Nat Struct Biol', 'ISO_journal': 'Nat. Struct. Biol.', 'authors': ['Poirier MA', 'Xiao W', 'Macosko JC', 'Chan C', 'Shin YK', 'Bennett MK.'], 'DOI_URL': 'http://dx.doi.org/10.1038/1799'}, 'PUB00018360': {'PMID': 9861047, 'ISBN': None, 'volume': '95', 'issue': '26', 'year': 1998, 'title': 'Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs.', 'URL': None, 'raw_pages': '15781-6', 'medline_journal': 'Proc Natl Acad Sci U S A', 'ISO_journal': 'Proc. Natl. Acad. Sci. U.S.A.', 'authors': ['Fasshauer D', 'Sutton RB', 'Brunger AT', 'Jahn R.'], 'DOI_URL': 'http://dx.doi.org/10.1073/pnas.95.26.15781'}, 'PUB00113733': {'PMID': 11252968, 'ISBN': None, 'volume': '2', 'issue': '2', 'year': 2001, 'title': 'SNARE-mediated membrane fusion.', 'URL': None, 'raw_pages': '98-106', 'medline_journal': 'Nat Rev Mol Cell Biol', 'ISO_journal': 'Nat Rev Mol Cell Biol', 'authors': ['Chen YA', 'Scheller RH.'], 'DOI_URL': None}, 'PUB00134568': {'PMID': 23073634, 'ISBN': None, 'volume': '92', 'issue': '4', 'year': 2012, 'title': 'Distinct initial SNARE configurations underlying the diversity of exocytosis.', 'URL': None, 'raw_pages': '1915-64', 'medline_journal': 'Physiol Rev', 'ISO_journal': 'Physiol Rev', 'authors': ['Kasai H', 'Takahashi N', 'Tokumaru H.'], 'DOI_URL': None}, 'PUB00134567': {'PMID': 24274740, 'ISBN': None, 'volume': '76', 'issue': None, 'year': 2014, 'title': 'Exocytosis and endocytosis: modes, functions, and coupling mechanisms.', 'URL': None, 'raw_pages': '301-31', 'medline_journal': 'Annu Rev Physiol', 'ISO_journal': 'Annu Rev Physiol', 'authors': ['Wu LG', 'Hamid E', 'Shin W', 'Chiang HC.'], 'DOI_URL': None}, 'PUB00113734': {'PMID': 11066058, 'ISBN': None, 'volume': '57', 'issue': '4', 'year': 2000, 'title': 'Fusion of membranes during the acrosome reaction: a tale of two SNAREs.', 'URL': None, 'raw_pages': '309-10', 'medline_journal': 'Mol Reprod Dev', 'ISO_journal': 'Mol Reprod Dev', 'authors': ['Kierszenbaum AL.'], 'DOI_URL': None}, 'PUB00113725': {'PMID': 9635186, 'ISBN': None, 'volume': '8', 'issue': '11', 'year': 1998, 'title': 'Membrane fusion: all done with SNAREpins?', 'URL': None, 'raw_pages': 'R390-3', 'medline_journal': 'Curr Biol', 'ISO_journal': 'Curr Biol', 'authors': ['Edwardson JM.'], 'DOI_URL': None}}"	""	"{'name': 'N-terminal SNARE motif of SNAP25', 'short': 'SNARE_SNAP25N'}"	""	"{'accession': '5w5c', 'name': 'Crystal structure of the primed SNARE-Complexin-Synaptotagmin-1 C2AB complex'}"	"{'accession': 'cl22856', 'name': 'SNARE'}"	"cdd"	"domain"	""