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{
"metadata": {
"accession": "cd12629",
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"name": {
"name": "RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)",
"short": "RRM2_IGF2BP2"
},
"description": [
{
"text": "<p>This subgroup corresponds to the RRM2 of IGF2BP2 (IGF2 mRNA-binding protein 2 or IMP-2), also termed hepatocellular carcinoma autoantigen p62, or VICKZ family member 2, a ubiquitously expressed RNA-binding protein involved in the stimulation of insulin action. It is predominantly nuclear. SNPs in IGF2BP2 gene are implicated in susceptibility to type 2 diabetes. IGF2BP2 plays an important role in cellular motility; it regulates the expression of PINCH-2, an important mediator of cell adhesion and motility, and MURF-3, a microtubule-stabilizing protein, through direct binding to their mRNAs. IGF2BP2 may be involved in the regulation of mRNA stability through the interaction with the AU-rich element-binding factor AUF1. In addition, IGF2BP2 binds initially to nascent beta-actin transcripts and facilitates the subsequent binding of the shuttling IGF2BP1. IGF2BP2 contains four hnRNP K-homology (KH) domains, two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and a RGG RNA-binding domain. [[cite:PUB00084493], [cite:PUB00084497], [cite:PUB00109307], [cite:PUB00109308], [cite:PUB00084488], [cite:PUB00084495], [cite:PUB00127764], [cite:PUB00084496], [cite:PUB00127765], [cite:PUB00079469], [cite:PUB00079470]]</p>",
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"PUB00084496": {
"PMID": 20956565,
"ISBN": null,
"volume": "30",
"issue": "24",
"year": 2010,
"title": "Role of the RNA-binding protein IMP-2 in muscle cell motility.",
"URL": null,
"raw_pages": "5710-25",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Boudoukha S",
"Cuvellier S",
"Polesskaya A."
],
"DOI_URL": "http://dx.doi.org/10.1128/MCB.00665-10"
},
"PUB00109307": {
"PMID": 15601260,
"ISBN": null,
"volume": "97",
"issue": "1",
"year": 2005,
"title": "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins.",
"URL": null,
"raw_pages": "87-96",
"medline_journal": "Biol Cell",
"ISO_journal": "Biol Cell",
"authors": [
"Yisraeli JK."
],
"DOI_URL": null
},
"PUB00079470": {
"PMID": 22278943,
"ISBN": null,
"volume": "3",
"issue": "2",
"year": 2012,
"title": "Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems.",
"URL": null,
"raw_pages": "229-46",
"medline_journal": "Wiley Interdiscip Rev RNA",
"ISO_journal": "Wiley Interdiscip Rev RNA",
"authors": [
"Muto Y",
"Yokoyama S."
],
"DOI_URL": "http://dx.doi.org/10.1002/wrna.1107"
},
"PUB00079469": {
"PMID": 22516180,
"ISBN": null,
"volume": "22",
"issue": "3",
"year": 2012,
"title": "Dynamics in multi-domain protein recognition of RNA.",
"URL": null,
"raw_pages": "287-96",
"medline_journal": "Curr Opin Struct Biol",
"ISO_journal": "Curr. Opin. Struct. Biol.",
"authors": [
"Mackereth CD",
"Sattler M."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.sbi.2012.03.013"
},
"PUB00084495": {
"PMID": 22032244,
"ISBN": null,
"volume": "31",
"issue": "5",
"year": 2012,
"title": "IGF2BP2 genetic variation and type 2 diabetes: a global meta-analysis.",
"URL": null,
"raw_pages": "713-20",
"medline_journal": "DNA Cell Biol",
"ISO_journal": "DNA Cell Biol.",
"authors": [
"Zhao Y",
"Ma YS",
"Fang Y",
"Liu L",
"Wu SD",
"Fu D",
"Wang XF."
],
"DOI_URL": "http://dx.doi.org/10.1089/dna.2011.1400"
},
"PUB00084493": {
"PMID": 9891060,
"ISBN": null,
"volume": "19",
"issue": "2",
"year": 1999,
"title": "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.",
"URL": null,
"raw_pages": "1262-70",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Nielsen J",
"Christiansen J",
"Lykke-Andersen J",
"Johnsen AH",
"Wewer UM",
"Nielsen FC."
],
"DOI_URL": "http://dx.doi.org/10.1128/MCB.19.2.1262"
},
"PUB00084488": {
"PMID": 20080952,
"ISBN": null,
"volume": "24",
"issue": "2",
"year": 2010,
"title": "ZBP1 recognition of beta-actin zipcode induces RNA looping.",
"URL": null,
"raw_pages": "148-58",
"medline_journal": "Genes Dev",
"ISO_journal": "Genes Dev.",
"authors": [
"Chao JA",
"Patskovsky Y",
"Patel V",
"Levy M",
"Almo SC",
"Singer RH."
],
"DOI_URL": "http://dx.doi.org/10.1101/gad.1862910"
},
"PUB00109308": {
"PMID": 16049158,
"ISBN": null,
"volume": "130",
"issue": "2",
"year": 2005,
"title": "Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer.",
"URL": null,
"raw_pages": "203-12",
"medline_journal": "Reproduction",
"ISO_journal": "Reproduction",
"authors": [
"Hammer NA",
"Hansen Tv",
"Byskov AG",
"Rajpert-De Meyts E",
"Grondahl ML",
"Bredkjaer HE",
"Wewer UM",
"Christiansen J",
"Nielsen FC."
],
"DOI_URL": null
},
"PUB00127764": {
"PMID": 21576258,
"ISBN": null,
"volume": "25",
"issue": "11",
"year": 2011,
"title": "mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.",
"URL": null,
"raw_pages": "1159-72",
"medline_journal": "Genes Dev",
"ISO_journal": "Genes Dev",
"authors": [
"Dai N",
"Rapley J",
"Angel M",
"Yanik MF",
"Blower MD",
"Avruch J."
],
"DOI_URL": null
},
"PUB00084497": {
"PMID": 12674497,
"ISBN": null,
"volume": "384",
"issue": "1",
"year": 2003,
"title": "Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D).",
"URL": null,
"raw_pages": "25-37",
"medline_journal": "Biol Chem",
"ISO_journal": "Biol. Chem.",
"authors": [
"Moraes KC",
"Quaresma AJ",
"Maehnss K",
"Kobarg J."
],
"DOI_URL": "http://dx.doi.org/10.1515/BC.2003.004"
},
"PUB00127765": {
"PMID": 19429674,
"ISBN": null,
"volume": "43",
"issue": "5",
"year": 2009,
"title": "IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes.",
"URL": null,
"raw_pages": "187-95",
"medline_journal": "J Mol Endocrinol",
"ISO_journal": "J Mol Endocrinol",
"authors": [
"Christiansen J",
"Kolte AM",
"Hansen Tv",
"Nielsen FC."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl17169",
"name": "RRM_SF"
},
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},
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"taxa": 973
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"is_llm": false,
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}
}
