"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"cd12629"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 641, 'pathways': 0, 'proteins': 641, 'proteomes': 259, 'sets': 1, 'structural_models': {'alphafold': 575, 'bfvd': 0}, 'structures': 0, 'taxa': 973}"	"{}"	"[{'text': '<p>This subgroup corresponds to the RRM2 of IGF2BP2 (IGF2 mRNA-binding protein 2 or IMP-2), also termed hepatocellular carcinoma autoantigen p62, or VICKZ family member 2, a ubiquitously expressed RNA-binding protein involved in the stimulation of insulin action. It is predominantly nuclear. SNPs in IGF2BP2 gene are implicated in susceptibility to type 2 diabetes. IGF2BP2 plays an important role in cellular motility; it regulates the expression of PINCH-2, an important mediator of cell adhesion and motility, and MURF-3, a microtubule-stabilizing protein, through direct binding to their mRNAs. IGF2BP2 may be involved in the regulation of mRNA stability through the interaction with the AU-rich element-binding factor AUF1. In addition, IGF2BP2 binds initially to nascent beta-actin transcripts and facilitates the subsequent binding of the shuttling IGF2BP1. IGF2BP2 contains four hnRNP K-homology (KH) domains, two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and a RGG RNA-binding domain.  [[cite:PUB00084493], [cite:PUB00084497], [cite:PUB00109307], [cite:PUB00109308], [cite:PUB00084488], [cite:PUB00084495], [cite:PUB00127764], [cite:PUB00084496], [cite:PUB00127765], [cite:PUB00079469], [cite:PUB00079470]]</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	""	False	False	False	"{'PUB00084496': {'PMID': 20956565, 'ISBN': None, 'volume': '30', 'issue': '24', 'year': 2010, 'title': 'Role of the RNA-binding protein IMP-2 in muscle cell motility.', 'URL': None, 'raw_pages': '5710-25', 'medline_journal': 'Mol Cell Biol', 'ISO_journal': 'Mol. Cell. Biol.', 'authors': ['Boudoukha S', 'Cuvellier S', 'Polesskaya A.'], 'DOI_URL': 'http://dx.doi.org/10.1128/MCB.00665-10'}, 'PUB00109307': {'PMID': 15601260, 'ISBN': None, 'volume': '97', 'issue': '1', 'year': 2005, 'title': 'VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins.', 'URL': None, 'raw_pages': '87-96', 'medline_journal': 'Biol Cell', 'ISO_journal': 'Biol Cell', 'authors': ['Yisraeli JK.'], 'DOI_URL': None}, 'PUB00079470': {'PMID': 22278943, 'ISBN': None, 'volume': '3', 'issue': '2', 'year': 2012, 'title': 'Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems.', 'URL': None, 'raw_pages': '229-46', 'medline_journal': 'Wiley Interdiscip Rev RNA', 'ISO_journal': 'Wiley Interdiscip Rev RNA', 'authors': ['Muto Y', 'Yokoyama S.'], 'DOI_URL': 'http://dx.doi.org/10.1002/wrna.1107'}, 'PUB00079469': {'PMID': 22516180, 'ISBN': None, 'volume': '22', 'issue': '3', 'year': 2012, 'title': 'Dynamics in multi-domain protein recognition of RNA.', 'URL': None, 'raw_pages': '287-96', 'medline_journal': 'Curr Opin Struct Biol', 'ISO_journal': 'Curr. Opin. Struct. Biol.', 'authors': ['Mackereth CD', 'Sattler M.'], 'DOI_URL': 'http://dx.doi.org/10.1016/j.sbi.2012.03.013'}, 'PUB00084495': {'PMID': 22032244, 'ISBN': None, 'volume': '31', 'issue': '5', 'year': 2012, 'title': 'IGF2BP2 genetic variation and type 2 diabetes: a global meta-analysis.', 'URL': None, 'raw_pages': '713-20', 'medline_journal': 'DNA Cell Biol', 'ISO_journal': 'DNA Cell Biol.', 'authors': ['Zhao Y', 'Ma YS', 'Fang Y', 'Liu L', 'Wu SD', 'Fu D', 'Wang XF.'], 'DOI_URL': 'http://dx.doi.org/10.1089/dna.2011.1400'}, 'PUB00084493': {'PMID': 9891060, 'ISBN': None, 'volume': '19', 'issue': '2', 'year': 1999, 'title': 'A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.', 'URL': None, 'raw_pages': '1262-70', 'medline_journal': 'Mol Cell Biol', 'ISO_journal': 'Mol. Cell. Biol.', 'authors': ['Nielsen J', 'Christiansen J', 'Lykke-Andersen J', 'Johnsen AH', 'Wewer UM', 'Nielsen FC.'], 'DOI_URL': 'http://dx.doi.org/10.1128/MCB.19.2.1262'}, 'PUB00084488': {'PMID': 20080952, 'ISBN': None, 'volume': '24', 'issue': '2', 'year': 2010, 'title': 'ZBP1 recognition of beta-actin zipcode induces RNA looping.', 'URL': None, 'raw_pages': '148-58', 'medline_journal': 'Genes Dev', 'ISO_journal': 'Genes Dev.', 'authors': ['Chao JA', 'Patskovsky Y', 'Patel V', 'Levy M', 'Almo SC', 'Singer RH.'], 'DOI_URL': 'http://dx.doi.org/10.1101/gad.1862910'}, 'PUB00109308': {'PMID': 16049158, 'ISBN': None, 'volume': '130', 'issue': '2', 'year': 2005, 'title': 'Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer.', 'URL': None, 'raw_pages': '203-12', 'medline_journal': 'Reproduction', 'ISO_journal': 'Reproduction', 'authors': ['Hammer NA', 'Hansen Tv', 'Byskov AG', 'Rajpert-De Meyts E', 'Grondahl ML', 'Bredkjaer HE', 'Wewer UM', 'Christiansen J', 'Nielsen FC.'], 'DOI_URL': None}, 'PUB00127764': {'PMID': 21576258, 'ISBN': None, 'volume': '25', 'issue': '11', 'year': 2011, 'title': 'mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.', 'URL': None, 'raw_pages': '1159-72', 'medline_journal': 'Genes Dev', 'ISO_journal': 'Genes Dev', 'authors': ['Dai N', 'Rapley J', 'Angel M', 'Yanik MF', 'Blower MD', 'Avruch J.'], 'DOI_URL': None}, 'PUB00084497': {'PMID': 12674497, 'ISBN': None, 'volume': '384', 'issue': '1', 'year': 2003, 'title': 'Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D).', 'URL': None, 'raw_pages': '25-37', 'medline_journal': 'Biol Chem', 'ISO_journal': 'Biol. Chem.', 'authors': ['Moraes KC', 'Quaresma AJ', 'Maehnss K', 'Kobarg J.'], 'DOI_URL': 'http://dx.doi.org/10.1515/BC.2003.004'}, 'PUB00127765': {'PMID': 19429674, 'ISBN': None, 'volume': '43', 'issue': '5', 'year': 2009, 'title': 'IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes.', 'URL': None, 'raw_pages': '187-95', 'medline_journal': 'J Mol Endocrinol', 'ISO_journal': 'J Mol Endocrinol', 'authors': ['Christiansen J', 'Kolte AM', 'Hansen Tv', 'Nielsen FC.'], 'DOI_URL': None}}"	""	"{'name': 'RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)', 'short': 'RRM2_IGF2BP2'}"	""	""	"{'accession': 'cl17169', 'name': 'RRM_SF'}"	"cdd"	"domain"	""