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"name": {
"name": "basic helix-loop-helix (bHLH) domain found in neurogenin (NGN) family",
"short": "bHLH_TS_NGN"
},
"description": [
{
"text": "<p>The NGN family includes three neural-specific bHLH transcription factors, NGN1-3, which may function at neuroblast selection genes during the development of several neuronal lineages. NGN-1, also termed Class A basic helix-loop-helix protein 6 (bHLHa6), or neurogenic basic-helix-loop-helix protein, or neurogenic differentiation factor 3 (NeuroD3), is a neural-specific bHLH transcription factor involved in the initiation of neuronal differentiation. NGN-2, also termed Class A basic helix-loop-helix protein 8 (bHLHa8), or protein atonal homolog 4 (ATOH4), is a neural-specific bHLH transcription factor required for sensory neurogenesis. NGN-3, also termed Class A basic helix-loop-helix protein 7 (bHLHa7), or protein atonal homolog 5 (ATOH5), is a neural-specific bHLH transcription factor expressed in the developing central nervous system and the embryonic pancreas. It is involved in neurogenesis and plays an important role in spermatogenesis. [[cite:PUB00143828], [cite:PUB00143829], [cite:PUB00143830], [cite:PUB00143831], [cite:PUB00143832], [cite:PUB00143833], [cite:PUB00143834], [cite:PUB00143835], [cite:PUB00143836], [cite:PUB00143837], [cite:PUB00143838], [cite:PUB00143839], [cite:PUB00143840], [cite:PUB00143841], [cite:PUB00107423], [cite:PUB00149589], [cite:PUB00149590], [cite:PUB00149591], [cite:PUB00149592], [cite:PUB00149593], [cite:PUB00101683], [cite:PUB00150149], [cite:PUB00101684], [cite:PUB00150150]]</p>",
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"ISBN": null,
"volume": "26",
"issue": "4",
"year": 2006,
"title": "Neurogenin 1 mediates erythropoietin enhanced differentiation of adult neural progenitor cells.",
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"raw_pages": "556-64",
"medline_journal": "J Cereb Blood Flow Metab",
"ISO_journal": "J Cereb Blood Flow Metab",
"authors": [
"Wang L",
"Zhang ZG",
"Zhang RL",
"Jiao ZX",
"Wang Y",
"Pourabdollah-Nejad D S",
"LeTourneau Y",
"Gregg SR",
"Chopp M."
],
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},
"PUB00101683": {
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"volume": "125",
"issue": "5",
"year": 2015,
"title": "Neurogenin 2 enhances the neuronal differentiation of skin-derived precursors.",
"URL": null,
"raw_pages": "367-74",
"medline_journal": "Int J Neurosci",
"ISO_journal": "Int J Neurosci",
"authors": [
"Dai X",
"Lu X",
"Cheng F",
"Hao H",
"Qian T",
"Yu W",
"Tang L",
"Li L."
],
"DOI_URL": null
},
"PUB00150150": {
"PMID": 12060754,
"ISBN": null,
"volume": "99",
"issue": "12",
"year": 2002,
"title": "Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate.",
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"raw_pages": "8084-9",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc Natl Acad Sci U S A",
"authors": [
"Zirlinger M",
"Lo L",
"McMahon J",
"McMahon AP",
"Anderson DJ."
],
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"ISBN": null,
"volume": "355",
"issue": "3",
"year": 2006,
"title": "Mutant neurogenin-3 in congenital malabsorptive diarrhea.",
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"raw_pages": "270-80",
"medline_journal": "N Engl J Med",
"ISO_journal": "N Engl J Med",
"authors": [
"Wang J",
"Cortina G",
"Wu SV",
"Tran R",
"Cho JH",
"Tsai MJ",
"Bailey TJ",
"Jamrich M",
"Ament ME",
"Treem WR",
"Hill ID",
"Vargas JH",
"Gershman G",
"Farmer DG",
"Reyen L",
"Martin MG."
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"ISBN": null,
"volume": "16",
"issue": "10",
"year": 1996,
"title": "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.",
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"raw_pages": "5792-800",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol Cell Biol",
"authors": [
"McCormick MB",
"Tamimi RM",
"Snider L",
"Asakura A",
"Bergstrom D",
"Tapscott SJ."
],
"DOI_URL": null
},
"PUB00143830": {
"PMID": 24450812,
"ISBN": null,
"volume": "47",
"issue": "1",
"year": 2014,
"title": "Expression pattern of Ngn3 in dairy goat testis and its function in promoting meiosis by upregulating Stra8.",
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"raw_pages": "38-47",
"medline_journal": "Cell Prolif",
"ISO_journal": "Cell Prolif",
"authors": [
"Tang F",
"Yao X",
"Zhu H",
"Mu H",
"Niu Z",
"Yu M",
"Yang C",
"Peng S",
"Li G",
"Hua J."
],
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"volume": "55",
"issue": "2",
"year": 2006,
"title": "Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3.",
"URL": null,
"raw_pages": "269-72",
"medline_journal": "Diabetes",
"ISO_journal": "Diabetes",
"authors": [
"Lee CS",
"De Leon DD",
"Kaestner KH",
"Stoffers DA."
],
"DOI_URL": null
},
"PUB00143839": {
"PMID": 12456641,
"ISBN": null,
"volume": "21",
"issue": "23",
"year": 2002,
"title": "Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium.",
"URL": null,
"raw_pages": "6338-47",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J",
"authors": [
"Jenny M",
"Uhl C",
"Roche C",
"Duluc I",
"Guillermin V",
"Guillemot F",
"Jensen J",
"Kedinger M",
"Gradwohl G."
],
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"volume": "50",
"issue": "3",
"year": 2001,
"title": "Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects.",
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"raw_pages": "694-6",
"medline_journal": "Diabetes",
"ISO_journal": "Diabetes",
"authors": [
"del Bosque-Plata L",
"Lin J",
"Horikawa Y",
"Schwarz PE",
"Cox NJ",
"Iwasaki N",
"Ogata M",
"Iwamoto Y",
"German MS",
"Bell GI."
],
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"ISBN": null,
"volume": "271",
"issue": "2",
"year": 2004,
"title": "Separable enhancer sequences regulate the expression of the neural bHLH transcription factor neurogenin 1.",
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"raw_pages": "479-87",
"medline_journal": "Dev Biol",
"ISO_journal": "Dev Biol",
"authors": [
"Nakada Y",
"Parab P",
"Simmons A",
"Omer-Abdalla A",
"Johnson JE."
],
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"volume": "1",
"issue": "12",
"year": 2012,
"title": "Complex regulation controls Neurogenin3 proteolysis.",
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"raw_pages": "1264-72",
"medline_journal": "Biol Open",
"ISO_journal": "Biol Open",
"authors": [
"Roark R",
"Itzhaki L",
"Philpott A."
],
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"PUB00143833": {
"PMID": 18924236,
"ISBN": null,
"volume": "237",
"issue": "11",
"year": 2008,
"title": "Biphasic Ngn3 expression in the developing pancreas.",
"URL": null,
"raw_pages": "3270-9",
"medline_journal": "Dev Dyn",
"ISO_journal": "Dev Dyn",
"authors": [
"Villasenor A",
"Chong DC",
"Cleaver O."
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"PUB00143840": {
"PMID": 12490199,
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"volume": "253",
"issue": "1",
"year": 2003,
"title": "Neurogenin3 participates in gliogenesis in the developing vertebrate spinal cord.",
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"raw_pages": "84-98",
"medline_journal": "Dev Biol",
"ISO_journal": "Dev Biol",
"authors": [
"Lee J",
"Wu Y",
"Qi Y",
"Xue H",
"Liu Y",
"Scheel D",
"German M",
"Qiu M",
"Guillemot F",
"Rao M",
"Gradwohl G."
],
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},
"PUB00150149": {
"PMID": 25217641,
"ISBN": null,
"volume": "289",
"issue": "45",
"year": 2014,
"title": "Neurogenin 2 mediates amyloid-β precursor protein-stimulated neurogenesis.",
"URL": null,
"raw_pages": "31253-61",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Bolos M",
"Hu Y",
"Young KM",
"Foa L",
"Small DH."
],
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},
"PUB00143837": {
"PMID": 15340143,
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"volume": "101",
"issue": "36",
"year": 2004,
"title": "Proendocrine genes coordinate the pancreatic islet differentiation program in vitro.",
"URL": null,
"raw_pages": "13245-50",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc Natl Acad Sci U S A",
"authors": [
"Gasa R",
"Mrejen C",
"Leachman N",
"Otten M",
"Barnes M",
"Wang J",
"Chakrabarti S",
"Mirmira R",
"German M."
],
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"volume": "269",
"issue": "2",
"year": 2004,
"title": "Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis.",
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"raw_pages": "447-58",
"medline_journal": "Dev Biol",
"ISO_journal": "Dev Biol",
"authors": [
"Yoshida S",
"Takakura A",
"Ohbo K",
"Abe K",
"Wakabayashi J",
"Yamamoto M",
"Suda T",
"Nabeshima Y."
],
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},
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"volume": "50",
"issue": "5",
"year": 2001,
"title": "Regulation of the pancreatic pro-endocrine gene neurogenin3.",
"URL": null,
"raw_pages": "928-36",
"medline_journal": "Diabetes",
"ISO_journal": "Diabetes",
"authors": [
"Lee JC",
"Smith SB",
"Watada H",
"Lin J",
"Scheel D",
"Wang J",
"Mirmira RG",
"German MS."
],
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},
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"volume": "4",
"issue": null,
"year": 2015,
"title": "Ngn1 inhibits astrogliogenesis through induction of miR-9 during neuronal fate specification.",
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"raw_pages": "e06885",
"medline_journal": "Elife",
"ISO_journal": "Elife",
"authors": [
"Zhao J",
"Lin Q",
"Kim KJ",
"Dardashti FD",
"Kim J",
"He F",
"Sun Y."
],
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"volume": "49",
"issue": "8",
"year": 2010,
"title": "The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a \"fuzzy\" complex upon DNA binding.",
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"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Aguado-Llera D",
"Goormaghtigh E",
"de Geest N",
"Quan XJ",
"Prieto A",
"Hassan BA",
"Gomez J",
"Neira JL."
],
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"title": "Neurogenin 1 (Neurog1) expression in the ventral neural tube is mediated by a distinct enhancer and preferentially marks ventral interneuron lineages.",
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"authors": [
"Quinones HI",
"Savage TK",
"Battiste J",
"Johnson JE."
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"title": "The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons.",
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"medline_journal": "Neuron",
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"authors": [
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"Gradwohl G",
"Morin X",
"Dierich A",
"LeMeur M",
"Goridis C",
"Guillemot F."
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"title": "Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells.",
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"medline_journal": "Genesis",
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"authors": [
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"Horb M."
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"title": "Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment.",
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"ISO_journal": "Dev Biol",
"authors": [
"Qu X",
"Afelik S",
"Jensen JN",
"Bukys MA",
"Kobberup S",
"Schmerr M",
"Xiao F",
"Nyeng P",
"Veronica Albertoni M",
"Grapin-Botton A",
"Jensen J."
],
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},
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"issue": "1",
"year": 2001,
"title": "A novel zebrafish bHLH gene, neurogenin3, is expressed in the hypothalamus.",
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"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Wang X",
"Chu LT",
"He J",
"Emelyanov A",
"Korzh V",
"Gong Z."
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