{"metadata":{"accession":"cd11428","entry_id":null,"type":"domain","go_terms":null,"source_database":"cdd","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"basic helix-loop-helix (bHLH) domain found in neurogenin (NGN) family","short":"bHLH_TS_NGN"},"description":[{"text":"<p>The NGN family includes three neural-specific bHLH transcription factors, NGN1-3, which may function at neuroblast selection genes during the development of several neuronal lineages. NGN-1, also termed Class A basic helix-loop-helix protein 6 (bHLHa6), or neurogenic basic-helix-loop-helix protein, or neurogenic differentiation factor 3 (NeuroD3), is a neural-specific bHLH transcription factor involved in the initiation of neuronal differentiation. NGN-2, also termed Class A basic helix-loop-helix protein 8 (bHLHa8), or protein atonal homolog 4 (ATOH4), is a neural-specific bHLH transcription factor required for sensory neurogenesis. NGN-3, also termed Class A basic helix-loop-helix protein 7 (bHLHa7), or protein atonal homolog 5 (ATOH5), is a neural-specific bHLH transcription factor expressed in the developing central nervous system and the embryonic pancreas. It is involved in neurogenesis and plays an important role in spermatogenesis. [[cite:PUB00143828], [cite:PUB00143829], [cite:PUB00143830], [cite:PUB00143831], [cite:PUB00143832], [cite:PUB00143833], [cite:PUB00143834], [cite:PUB00143835], [cite:PUB00143836], [cite:PUB00143837], [cite:PUB00143838], [cite:PUB00143839], [cite:PUB00143840], [cite:PUB00143841], [cite:PUB00107423], [cite:PUB00149589], [cite:PUB00149590], [cite:PUB00149591], [cite:PUB00149592], [cite:PUB00149593], [cite:PUB00101683], [cite:PUB00150149], [cite:PUB00101684], [cite:PUB00150150]]</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00149591":{"PMID":16136056,"ISBN":null,"volume":"26","issue":"4","year":2006,"title":"Neurogenin 1 mediates erythropoietin enhanced differentiation of adult neural progenitor cells.","URL":null,"raw_pages":"556-64","medline_journal":"J Cereb Blood Flow Metab","ISO_journal":"J Cereb Blood Flow Metab","authors":["Wang L","Zhang ZG","Zhang RL","Jiao ZX","Wang Y","Pourabdollah-Nejad D S","LeTourneau Y","Gregg SR","Chopp M."],"DOI_URL":null},"PUB00101683":{"PMID":24946204,"ISBN":null,"volume":"125","issue":"5","year":2015,"title":"Neurogenin 2 enhances the neuronal differentiation of skin-derived precursors.","URL":null,"raw_pages":"367-74","medline_journal":"Int J Neurosci","ISO_journal":"Int J Neurosci","authors":["Dai X","Lu X","Cheng F","Hao H","Qian T","Yu W","Tang L","Li L."],"DOI_URL":null},"PUB00150150":{"PMID":12060754,"ISBN":null,"volume":"99","issue":"12","year":2002,"title":"Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate.","URL":null,"raw_pages":"8084-9","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Zirlinger M","Lo L","McMahon J","McMahon AP","Anderson DJ."],"DOI_URL":null},"PUB00143828":{"PMID":16855267,"ISBN":null,"volume":"355","issue":"3","year":2006,"title":"Mutant neurogenin-3 in congenital malabsorptive diarrhea.","URL":null,"raw_pages":"270-80","medline_journal":"N Engl J Med","ISO_journal":"N Engl J Med","authors":["Wang J","Cortina G","Wu SV","Tran R","Cho JH","Tsai MJ","Bailey TJ","Jamrich M","Ament ME","Treem WR","Hill ID","Vargas JH","Gershman G","Farmer DG","Reyen L","Martin MG."],"DOI_URL":null},"PUB00107423":{"PMID":8816493,"ISBN":null,"volume":"16","issue":"10","year":1996,"title":"NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.","URL":null,"raw_pages":"5792-800","medline_journal":"Mol Cell Biol","ISO_journal":"Mol Cell Biol","authors":["McCormick MB","Tamimi RM","Snider L","Asakura A","Bergstrom D","Tapscott SJ."],"DOI_URL":null},"PUB00143830":{"PMID":24450812,"ISBN":null,"volume":"47","issue":"1","year":2014,"title":"Expression pattern of Ngn3 in dairy goat testis and its function in promoting meiosis by upregulating Stra8.","URL":null,"raw_pages":"38-47","medline_journal":"Cell Prolif","ISO_journal":"Cell Prolif","authors":["Tang F","Yao X","Zhu H","Mu H","Niu Z","Yu M","Yang C","Peng S","Li G","Hua J."],"DOI_URL":null},"PUB00143836":{"PMID":16361411,"ISBN":null,"volume":"55","issue":"2","year":2006,"title":"Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3.","URL":null,"raw_pages":"269-72","medline_journal":"Diabetes","ISO_journal":"Diabetes","authors":["Lee CS","De Leon DD","Kaestner KH","Stoffers DA."],"DOI_URL":null},"PUB00143839":{"PMID":12456641,"ISBN":null,"volume":"21","issue":"23","year":2002,"title":"Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium.","URL":null,"raw_pages":"6338-47","medline_journal":"EMBO J","ISO_journal":"EMBO J","authors":["Jenny M","Uhl C","Roche C","Duluc I","Guillermin V","Guillemot F","Jensen J","Kedinger M","Gradwohl G."],"DOI_URL":null},"PUB00143829":{"PMID":11246894,"ISBN":null,"volume":"50","issue":"3","year":2001,"title":"Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects.","URL":null,"raw_pages":"694-6","medline_journal":"Diabetes","ISO_journal":"Diabetes","authors":["del Bosque-Plata L","Lin J","Horikawa Y","Schwarz PE","Cox NJ","Iwasaki N","Ogata M","Iwamoto Y","German MS","Bell GI."],"DOI_URL":null},"PUB00149592":{"PMID":15223348,"ISBN":null,"volume":"271","issue":"2","year":2004,"title":"Separable enhancer sequences regulate the expression of the neural bHLH transcription factor neurogenin 1.","URL":null,"raw_pages":"479-87","medline_journal":"Dev Biol","ISO_journal":"Dev Biol","authors":["Nakada Y","Parab P","Simmons A","Omer-Abdalla A","Johnson JE."],"DOI_URL":null},"PUB00143834":{"PMID":23259061,"ISBN":null,"volume":"1","issue":"12","year":2012,"title":"Complex regulation controls Neurogenin3 proteolysis.","URL":null,"raw_pages":"1264-72","medline_journal":"Biol Open","ISO_journal":"Biol Open","authors":["Roark R","Itzhaki L","Philpott A."],"DOI_URL":null},"PUB00143833":{"PMID":18924236,"ISBN":null,"volume":"237","issue":"11","year":2008,"title":"Biphasic Ngn3 expression in the developing pancreas.","URL":null,"raw_pages":"3270-9","medline_journal":"Dev Dyn","ISO_journal":"Dev Dyn","authors":["Villasenor A","Chong DC","Cleaver O."],"DOI_URL":null},"PUB00143840":{"PMID":12490199,"ISBN":null,"volume":"253","issue":"1","year":2003,"title":"Neurogenin3 participates in gliogenesis in the developing vertebrate spinal cord.","URL":null,"raw_pages":"84-98","medline_journal":"Dev Biol","ISO_journal":"Dev Biol","authors":["Lee J","Wu Y","Qi Y","Xue H","Liu Y","Scheel D","German M","Qiu M","Guillemot F","Rao M","Gradwohl G."],"DOI_URL":null},"PUB00150149":{"PMID":25217641,"ISBN":null,"volume":"289","issue":"45","year":2014,"title":"Neurogenin 2 mediates amyloid-β precursor protein-stimulated neurogenesis.","URL":null,"raw_pages":"31253-61","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Bolos M","Hu Y","Young KM","Foa L","Small DH."],"DOI_URL":null},"PUB00143837":{"PMID":15340143,"ISBN":null,"volume":"101","issue":"36","year":2004,"title":"Proendocrine genes coordinate the pancreatic islet differentiation program in vitro.","URL":null,"raw_pages":"13245-50","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Gasa R","Mrejen C","Leachman N","Otten M","Barnes M","Wang J","Chakrabarti S","Mirmira R","German M."],"DOI_URL":null},"PUB00143841":{"PMID":15110712,"ISBN":null,"volume":"269","issue":"2","year":2004,"title":"Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis.","URL":null,"raw_pages":"447-58","medline_journal":"Dev Biol","ISO_journal":"Dev Biol","authors":["Yoshida S","Takakura A","Ohbo K","Abe K","Wakabayashi J","Yamamoto M","Suda T","Nabeshima Y."],"DOI_URL":null},"PUB00143838":{"PMID":11334435,"ISBN":null,"volume":"50","issue":"5","year":2001,"title":"Regulation of the pancreatic pro-endocrine gene neurogenin3.","URL":null,"raw_pages":"928-36","medline_journal":"Diabetes","ISO_journal":"Diabetes","authors":["Lee JC","Smith SB","Watada H","Lin J","Scheel D","Wang J","Mirmira RG","German MS."],"DOI_URL":null},"PUB00149589":{"PMID":26271009,"ISBN":null,"volume":"4","issue":null,"year":2015,"title":"Ngn1 inhibits astrogliogenesis through induction of miR-9 during neuronal fate specification.","URL":null,"raw_pages":"e06885","medline_journal":"Elife","ISO_journal":"Elife","authors":["Zhao J","Lin Q","Kim KJ","Dardashti FD","Kim J","He F","Sun Y."],"DOI_URL":null},"PUB00149590":{"PMID":20102160,"ISBN":null,"volume":"49","issue":"8","year":2010,"title":"The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a \"fuzzy\" complex upon DNA binding.","URL":null,"raw_pages":"1577-89","medline_journal":"Biochemistry","ISO_journal":"Biochemistry","authors":["Aguado-Llera D","Goormaghtigh E","de Geest N","Quan XJ","Prieto A","Hassan BA","Gomez J","Neira JL."],"DOI_URL":null},"PUB00149593":{"PMID":20171205,"ISBN":null,"volume":"340","issue":"2","year":2010,"title":"Neurogenin 1 (Neurog1) expression in the ventral neural tube is mediated by a distinct enhancer and preferentially marks ventral interneuron lineages.","URL":null,"raw_pages":"283-92","medline_journal":"Dev Biol","ISO_journal":"Dev Biol","authors":["Quinones HI","Savage TK","Battiste J","Johnson JE."],"DOI_URL":null},"PUB00101684":{"PMID":9539123,"ISBN":null,"volume":"20","issue":"3","year":1998,"title":"The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons.","URL":null,"raw_pages":"483-94","medline_journal":"Neuron","ISO_journal":"Neuron","authors":["Fode C","Gradwohl G","Morin X","Dierich A","LeMeur M","Goridis C","Guillemot F."],"DOI_URL":null},"PUB00143832":{"PMID":22121111,"ISBN":null,"volume":"50","issue":"3","year":2012,"title":"Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells.","URL":null,"raw_pages":"271-85","medline_journal":"Genesis","ISO_journal":"Genesis","authors":["Oropeza D","Horb M."],"DOI_URL":null},"PUB00143831":{"PMID":23370147,"ISBN":null,"volume":"376","issue":"1","year":2013,"title":"Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment.","URL":null,"raw_pages":"1-12","medline_journal":"Dev Biol","ISO_journal":"Dev Biol","authors":["Qu X","Afelik S","Jensen JN","Bukys MA","Kobberup S","Schmerr M","Xiao F","Nyeng P","Veronica Albertoni M","Grapin-Botton A","Jensen J."],"DOI_URL":null},"PUB00143835":{"PMID":11574151,"ISBN":null,"volume":"275","issue":"1","year":2001,"title":"A novel zebrafish bHLH gene, neurogenin3, is expressed in the hypothalamus.","URL":null,"raw_pages":"47-55","medline_journal":"Gene","ISO_journal":"Gene","authors":["Wang X","Chu LT","He J","Emelyanov A","Korzh V","Gong Z."],"DOI_URL":null}},"set_info":{"accession":"cl00081","name":"bHLH_SF"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":423,"pathways":0,"proteins":423,"proteomes":337,"sets":1,"structural_models":{"alphafold":379,"bfvd":0},"structures":0,"taxa":1402},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}