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"metadata": {
"accession": "cd11386",
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"name": {
"name": "Methyl-accepting chemotaxis protein (MCP), signaling domain",
"short": "MCP_signal"
},
"description": [
{
"text": "<p>Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW. [[cite:PUB00080398], [cite:PUB00040013], [cite:PUB00129171], [cite:PUB00129172]]</p>",
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"PUB00040013": {
"PMID": 16622408,
"ISBN": null,
"volume": "13",
"issue": "5",
"year": 2006,
"title": "Reconstruction of the chemotaxis receptor-kinase assembly.",
"URL": null,
"raw_pages": "400-7",
"medline_journal": "Nat Struct Mol Biol",
"ISO_journal": "Nat. Struct. Mol. Biol.",
"authors": [
"Park SY",
"Borbat PP",
"Gonzalez-Bonet G",
"Bhatnagar J",
"Pollard AM",
"Freed JH",
"Bilwes AM",
"Crane BR."
],
"DOI_URL": "http://dx.doi.org/10.1038/nsmb1085"
},
"PUB00080398": {
"PMID": 18165013,
"ISBN": null,
"volume": "33",
"issue": "1",
"year": 2008,
"title": "Bacterial chemoreceptors: high-performance signaling in networked arrays.",
"URL": null,
"raw_pages": "9-19",
"medline_journal": "Trends Biochem Sci",
"ISO_journal": "Trends Biochem. Sci.",
"authors": [
"Hazelbauer GL",
"Falke JJ",
"Parkinson JS."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.tibs.2007.09.014"
},
"PUB00129171": {
"PMID": 20738376,
"ISBN": null,
"volume": "12",
"issue": "11",
"year": 2010,
"title": "Sensing of environmental signals: classification of chemoreceptors according to the size of their ligand binding regions.",
"URL": null,
"raw_pages": "2873-84",
"medline_journal": "Environ Microbiol",
"ISO_journal": "Environ Microbiol",
"authors": [
"Lacal J",
"Garcia-Fontana C",
"Munoz-Martinez F",
"Ramos JL",
"Krell T."
],
"DOI_URL": null
},
"PUB00129172": {
"PMID": 20411245,
"ISBN": null,
"volume": "192",
"issue": "7",
"year": 2010,
"title": "Bacterial energy taxis: a global strategy?",
"URL": null,
"raw_pages": "507-20",
"medline_journal": "Arch Microbiol",
"ISO_journal": "Arch Microbiol",
"authors": [
"Schweinitzer T",
"Josenhans C."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl39097",
"name": "MCP_signal"
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},
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