{"metadata":{"accession":"cd11386","entry_id":null,"type":"domain","go_terms":null,"source_database":"cdd","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"Methyl-accepting chemotaxis protein (MCP), signaling domain","short":"MCP_signal"},"description":[{"text":"<p>Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW. [[cite:PUB00080398], [cite:PUB00040013], [cite:PUB00129171], [cite:PUB00129172]]</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00040013":{"PMID":16622408,"ISBN":null,"volume":"13","issue":"5","year":2006,"title":"Reconstruction of the chemotaxis receptor-kinase assembly.","URL":null,"raw_pages":"400-7","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Park SY","Borbat PP","Gonzalez-Bonet G","Bhatnagar J","Pollard AM","Freed JH","Bilwes AM","Crane BR."],"DOI_URL":"http://dx.doi.org/10.1038/nsmb1085"},"PUB00080398":{"PMID":18165013,"ISBN":null,"volume":"33","issue":"1","year":2008,"title":"Bacterial chemoreceptors: high-performance signaling in networked arrays.","URL":null,"raw_pages":"9-19","medline_journal":"Trends Biochem Sci","ISO_journal":"Trends Biochem. Sci.","authors":["Hazelbauer GL","Falke JJ","Parkinson JS."],"DOI_URL":"http://dx.doi.org/10.1016/j.tibs.2007.09.014"},"PUB00129171":{"PMID":20738376,"ISBN":null,"volume":"12","issue":"11","year":2010,"title":"Sensing of environmental signals: classification of chemoreceptors according to the size of their ligand binding regions.","URL":null,"raw_pages":"2873-84","medline_journal":"Environ Microbiol","ISO_journal":"Environ Microbiol","authors":["Lacal J","Garcia-Fontana C","Munoz-Martinez F","Ramos JL","Krell T."],"DOI_URL":null},"PUB00129172":{"PMID":20411245,"ISBN":null,"volume":"192","issue":"7","year":2010,"title":"Bacterial energy taxis: a global strategy?","URL":null,"raw_pages":"507-20","medline_journal":"Arch Microbiol","ISO_journal":"Arch Microbiol","authors":["Schweinitzer T","Josenhans C."],"DOI_URL":null}},"set_info":{"accession":"cl39097","name":"MCP_signal"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":124360,"pathways":0,"proteins":124357,"proteomes":7611,"sets":1,"structural_models":{"alphafold":93983,"bfvd":0},"structures":14,"taxa":13654},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}