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{
"metadata": {
"accession": "cd07673",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": "IPR030122",
"hierarchy": null,
"name": {
"name": "The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein",
"short": "F-BAR_FCHO2"
},
"description": [
{
"text": "<p>F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. The specific function of FCH domain Only 2 (FCHO2) is still unknown. It contains an N-terminal F-BAR domain and a C-terminal domain of unknown function named SAFF which is also present in FCHO1 and endophilin interacting protein 1. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules. [[cite:PUB00043263], [cite:PUB00122543], [cite:PUB00068557], [cite:PUB00084652], [cite:PUB00068608], [cite:PUB00122051], [cite:PUB00106926], [cite:PUB00122056], [cite:PUB00122057], [cite:PUB00073997], [cite:PUB00122393], [cite:PUB00073998]]</p>",
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}
],
"wikipedia": null,
"literature": {
"PUB00122393": {
"PMID": 17074490,
"ISBN": null,
"volume": "31",
"issue": "12",
"year": 2006,
"title": "Pombe Cdc15 homology proteins: regulators of membrane dynamics and the actin cytoskeleton.",
"URL": null,
"raw_pages": "670-9",
"medline_journal": "Trends Biochem Sci",
"ISO_journal": "Trends Biochem Sci",
"authors": [
"Aspenstrom P",
"Fransson A",
"Richnau N."
],
"DOI_URL": null
},
"PUB00106926": {
"PMID": 16938488,
"ISBN": null,
"volume": "1761",
"issue": "8",
"year": 2006,
"title": "BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane-cytosol interfaces and membrane curvature.",
"URL": null,
"raw_pages": "897-912",
"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim Biophys Acta",
"authors": [
"Itoh T",
"De Camilli P."
],
"DOI_URL": null
},
"PUB00122056": {
"PMID": 17637334,
"ISBN": null,
"volume": "15",
"issue": "7",
"year": 2007,
"title": "F-BAR proteins join the BAR family fold.",
"URL": null,
"raw_pages": "751-3",
"medline_journal": "Structure",
"ISO_journal": "Structure",
"authors": [
"Frost A",
"De Camilli P",
"Unger VM."
],
"DOI_URL": null
},
"PUB00122057": {
"PMID": 18329367,
"ISBN": null,
"volume": "132",
"issue": "5",
"year": 2008,
"title": "Structural basis of membrane invagination by F-BAR domains.",
"URL": null,
"raw_pages": "807-17",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Frost A",
"Perera R",
"Roux A",
"Spasov K",
"Destaing O",
"Egelman EH",
"De Camilli P",
"Unger VM."
],
"DOI_URL": null
},
"PUB00043263": {
"PMID": 17540576,
"ISBN": null,
"volume": "15",
"issue": "7",
"year": 2007,
"title": "Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature.",
"URL": null,
"raw_pages": "839-52",
"medline_journal": "Structure",
"ISO_journal": "Structure",
"authors": [
"Henne WM",
"Kent HM",
"Ford MG",
"Hegde BG",
"Daumke O",
"Butler PJ",
"Mittal R",
"Langen R",
"Evans PR",
"McMahon HT."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.str.2007.05.002"
},
"PUB00068557": {
"PMID": 19379681,
"ISBN": null,
"volume": "137",
"issue": "2",
"year": 2009,
"title": "The BAR domain superfamily: membrane-molding macromolecules.",
"URL": null,
"raw_pages": "191-6",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Frost A",
"Unger VM",
"De Camilli P."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.cell.2009.04.010"
},
"PUB00122543": {
"PMID": 15254787,
"ISBN": null,
"volume": "14",
"issue": "2",
"year": 2004,
"title": "Identification and characterization of human FCHO2 and mouse Fcho2 genes in silico.",
"URL": null,
"raw_pages": "327-31",
"medline_journal": "Int J Mol Med",
"ISO_journal": "Int J Mol Med",
"authors": [
"Katoh M",
"Katoh M."
],
"DOI_URL": null
},
"PUB00084652": {
"PMID": 19121815,
"ISBN": null,
"volume": "272",
"issue": null,
"year": 2009,
"title": "Roles of F-BAR/PCH proteins in the regulation of membrane dynamics and actin reorganization.",
"URL": null,
"raw_pages": "1-31",
"medline_journal": "Int Rev Cell Mol Biol",
"ISO_journal": "Int Rev Cell Mol Biol",
"authors": [
"Aspenstrom P."
],
"DOI_URL": "https://doi.org/10.1016/S1937-6448(08)01601-8"
},
"PUB00122051": {
"PMID": 17512400,
"ISBN": null,
"volume": "129",
"issue": "4",
"year": 2007,
"title": "\"Wunder\" F-BAR domains: going from pits to vesicles.",
"URL": null,
"raw_pages": "655-7",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Futterer K",
"Machesky LM."
],
"DOI_URL": null
},
"PUB00073997": {
"PMID": 10816256,
"ISBN": null,
"volume": "49",
"issue": "2",
"year": 2000,
"title": "Involvement of PCH family proteins in cytokinesis and actin distribution.",
"URL": null,
"raw_pages": "168-72",
"medline_journal": "Microsc Res Tech",
"ISO_journal": "Microsc. Res. Tech.",
"authors": [
"Lippincott J",
"Li R."
],
"DOI_URL": "http://dx.doi.org/10.1002/(SICI)1097-0029(20000415)49:2<168::AID-JEMT9>3.0.CO;2-T"
},
"PUB00068608": {
"PMID": 18525024,
"ISBN": null,
"volume": "121",
"issue": "Pt 12",
"year": 2008,
"title": "F-BAR domains: multifunctional regulators of membrane curvature.",
"URL": null,
"raw_pages": "1951-4",
"medline_journal": "J Cell Sci",
"ISO_journal": "J. Cell. Sci.",
"authors": [
"Heath RJ",
"Insall RH."
],
"DOI_URL": "http://dx.doi.org/10.1242/jcs.023895"
},
"PUB00073998": {
"PMID": 17296299,
"ISBN": null,
"volume": "17",
"issue": "3",
"year": 2007,
"title": "Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions.",
"URL": null,
"raw_pages": "145-56",
"medline_journal": "Trends Cell Biol",
"ISO_journal": "Trends Cell Biol.",
"authors": [
"Chitu V",
"Stanley ER."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.tcb.2007.01.003"
}
},
"set_info": {
"accession": "cl12013",
"name": "BAR"
},
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"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 1062,
"pathways": 0,
"proteins": 1062,
"proteomes": 392,
"sets": 1,
"structural_models": {
"alphafold": 960,
"bfvd": 0
},
"structures": 0,
"taxa": 1409
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
