{"metadata":{"accession":"cd07673","entry_id":null,"type":"domain","go_terms":null,"source_database":"cdd","member_databases":null,"integrated":"IPR030122","hierarchy":null,"name":{"name":"The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein","short":"F-BAR_FCHO2"},"description":[{"text":"<p>F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. The specific function of FCH domain Only 2 (FCHO2) is still unknown. It contains an N-terminal F-BAR domain and a C-terminal domain of unknown function named SAFF which is also present in FCHO1 and endophilin interacting protein 1. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules. 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Res. Tech.","authors":["Lippincott J","Li R."],"DOI_URL":"http://dx.doi.org/10.1002/(SICI)1097-0029(20000415)49:2<168::AID-JEMT9>3.0.CO;2-T"},"PUB00068608":{"PMID":18525024,"ISBN":null,"volume":"121","issue":"Pt 12","year":2008,"title":"F-BAR domains: multifunctional regulators of membrane curvature.","URL":null,"raw_pages":"1951-4","medline_journal":"J Cell Sci","ISO_journal":"J. Cell. Sci.","authors":["Heath RJ","Insall RH."],"DOI_URL":"http://dx.doi.org/10.1242/jcs.023895"},"PUB00073998":{"PMID":17296299,"ISBN":null,"volume":"17","issue":"3","year":2007,"title":"Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions.","URL":null,"raw_pages":"145-56","medline_journal":"Trends Cell Biol","ISO_journal":"Trends Cell Biol.","authors":["Chitu V","Stanley ER."],"DOI_URL":"http://dx.doi.org/10.1016/j.tcb.2007.01.003"}},"set_info":{"accession":"cl12013","name":"BAR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":1062,"pathways":0,"proteins":1062,"proteomes":392,"sets":1,"structural_models":{"alphafold":960,"bfvd":0},"structures":0,"taxa":1409},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}