HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept
{
"metadata": {
"accession": "cd04860",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": "IPR014052",
"hierarchy": null,
"name": {
"name": null,
"short": "AE_Prim_S"
},
"description": [
{
"text": "<p>AE_Prim_S: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. Primases are DNA-dependent RNA polymerases which synthesis the short RNA primers required for DNA replication. In addition to its catalytic role in replication, DNA primase may play a role in coupling replication to DNA damage repair and in checkpoint control during S phase. In eukaryotes, this small catalytically active primase subunit (p50) and a larger primase subunit (p60), referred to jointly as the core primase, associate with the B subunit and the DNA polymerase alpha subunit in a complex, called Pol alpha-pri. The function of the larger primase subunit is unclear. Included in this group are Pfu41 and Pfu46, these two proteins comprise the primase complex of the archaea Pyrococcus furiosus; Pfu41 and Pfu46 have sequence identity to the eukaryotic p50 and p60 primase proteins respectively. Pfu41 preferentially uses dNTPs as substrate. Pfu46 regulates the primase activity of Pfu41. [[cite:PUB00005693], [cite:PUB00112128], [cite:PUB00039010], [cite:PUB00112129], [cite:PUB00112130], [cite:PUB00033236], [cite:PUB00037913], [cite:PUB00025150], [cite:PUB00070916], [cite:PUB00009771], [cite:PUB00112131], [cite:PUB00090446], [cite:PUB00112132], [cite:PUB00112133], [cite:PUB00112134], [cite:PUB00112135], [cite:PUB00112136], [cite:PUB00112137], [cite:PUB00112138], [cite:PUB00112139], [cite:PUB00112140], [cite:PUB00112141], [cite:PUB00112142], [cite:PUB00112143], [cite:PUB00112144], [cite:PUB00009837], [cite:PUB00112145], [cite:PUB00112146], [cite:PUB00044946], [cite:PUB00112125], [cite:PUB00112124], [cite:PUB00116964]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00112139": {
"PMID": 10504261,
"ISBN": null,
"volume": "38",
"issue": "39",
"year": 1999,
"title": "Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit.",
"URL": null,
"raw_pages": "12899-907",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Arezi B",
"Kirk BW",
"Copeland WC",
"Kuchta RD."
],
"DOI_URL": null
},
"PUB00070916": {
"PMID": 12806117,
"ISBN": null,
"volume": "3",
"issue": null,
"year": 2003,
"title": "The DNA polymerase alpha-primase complex: multiple functions and interactions.",
"URL": null,
"raw_pages": "21-33",
"medline_journal": "ScientificWorldJournal",
"ISO_journal": "ScientificWorldJournal",
"authors": [
"Muzi-Falconi M",
"Giannattasio M",
"Foiani M",
"Plevani P."
],
"DOI_URL": "http://dx.doi.org/10.1100/tsw.2003.05"
},
"PUB00112130": {
"PMID": 11584001,
"ISBN": null,
"volume": "276",
"issue": "48",
"year": 2001,
"title": "The archaeal DNA primase: biochemical characterization of the p41-p46 complex from Pyrococcus furiosus.",
"URL": null,
"raw_pages": "45484-90",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Liu L",
"Komori K",
"Ishino S",
"Bocquier AA",
"Cann IK",
"Kohda D",
"Ishino Y."
],
"DOI_URL": null
},
"PUB00112140": {
"PMID": 11917009,
"ISBN": null,
"volume": "30",
"issue": "7",
"year": 2002,
"title": "Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase alpha-primase.",
"URL": null,
"raw_pages": "1493-9",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res",
"authors": [
"Melle C",
"Nasheuer HP."
],
"DOI_URL": null
},
"PUB00112143": {
"PMID": 3061469,
"ISBN": null,
"volume": "951",
"issue": "2-3",
"year": 1988,
"title": "The yeast DNA polymerase-primase complex: genes and proteins.",
"URL": null,
"raw_pages": "268-73",
"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim Biophys Acta",
"authors": [
"Plevani P",
"Foiani M",
"Muzi Falconi M",
"Pizzagalli A",
"Santocanale C",
"Francesconi S",
"Valsasnini P",
"Comedini A",
"Piatti S",
"Lucchini G."
],
"DOI_URL": null
},
"PUB00112132": {
"PMID": 14674773,
"ISBN": null,
"volume": "42",
"issue": "50",
"year": 2003,
"title": "Distinct domain functions regulating de novo DNA synthesis of thermostable DNA primase from hyperthermophile Pyrococcus horikoshii.",
"URL": null,
"raw_pages": "14968-76",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Matsui E",
"Nishio M",
"Yokoyama H",
"Harata K",
"Darnis S",
"Matsui I."
],
"DOI_URL": null
},
"PUB00112129": {
"PMID": 16095750,
"ISBN": null,
"volume": "21",
"issue": "10",
"year": 2005,
"title": "The promiscuous primase.",
"URL": null,
"raw_pages": "568-72",
"medline_journal": "Trends Genet",
"ISO_journal": "Trends Genet",
"authors": [
"Lao-Sirieix SH",
"Pellegrini L",
"Bell SD."
],
"DOI_URL": null
},
"PUB00025150": {
"PMID": 11135672,
"ISBN": null,
"volume": "8",
"issue": "1",
"year": 2001,
"title": "Crystal structure of a DNA-dependent RNA polymerase (DNA primase).",
"URL": null,
"raw_pages": "57-61",
"medline_journal": "Nat Struct Biol",
"ISO_journal": "Nat. Struct. Biol.",
"authors": [
"Augustin MA",
"Huber R",
"Kaiser JT."
],
"DOI_URL": "http://dx.doi.org/10.1038/83060"
},
"PUB00039010": {
"PMID": 16273105,
"ISBN": null,
"volume": "12",
"issue": "12",
"year": 2005,
"title": "Structure of the heterodimeric core primase.",
"URL": null,
"raw_pages": "1137-44",
"medline_journal": "Nat Struct Mol Biol",
"ISO_journal": "Nat. Struct. Mol. Biol.",
"authors": [
"Lao-Sirieix SH",
"Nookala RK",
"Roversi P",
"Bell SD",
"Pellegrini L."
],
"DOI_URL": "http://dx.doi.org/10.1038/nsmb1013"
},
"PUB00090446": {
"PMID": 15755447,
"ISBN": null,
"volume": "347",
"issue": "3",
"year": 2005,
"title": "Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.",
"URL": null,
"raw_pages": "509-21",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Nedelcheva MN",
"Roguev A",
"Dolapchiev LB",
"Shevchenko A",
"Taskov HB",
"Shevchenko A",
"Stewart AF",
"Stoynov SS."
],
"DOI_URL": "https://doi.org/10.1016/j.jmb.2005.01.041"
},
"PUB00005693": {
"PMID": 2023935,
"ISBN": null,
"volume": "88",
"issue": "9",
"year": 1991,
"title": "Mutations in conserved yeast DNA primase domains impair DNA replication in vivo.",
"URL": null,
"raw_pages": "3877-81",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Francesconi S",
"Longhese MP",
"Piseri A",
"Santocanale C",
"Lucchini G",
"Plevani P."
],
"DOI_URL": "http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=2023935"
},
"PUB00112137": {
"PMID": 9705292,
"ISBN": null,
"volume": "273",
"issue": "34",
"year": 1998,
"title": "Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit.",
"URL": null,
"raw_pages": "21608-15",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Schneider A",
"Smith RW",
"Kautz AR",
"Weisshart K",
"Grosse F",
"Nasheuer HP."
],
"DOI_URL": null
},
"PUB00116964": {
"PMID": 11395402,
"ISBN": null,
"volume": "70",
"issue": null,
"year": 2001,
"title": "DNA primases.",
"URL": null,
"raw_pages": "39-80",
"medline_journal": "Annu Rev Biochem",
"ISO_journal": "Annu Rev Biochem",
"authors": [
"Frick DN",
"Richardson CC."
],
"DOI_URL": null
},
"PUB00112138": {
"PMID": 10441007,
"ISBN": null,
"volume": "26",
"issue": "1",
"year": 1999,
"title": "Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma.",
"URL": null,
"raw_pages": "62-9",
"medline_journal": "Genes Chromosomes Cancer",
"ISO_journal": "Genes Chromosomes Cancer",
"authors": [
"Yotov WV",
"Hamel H",
"Rivard GE",
"Champagne MA",
"Russo PA",
"Leclerc JM",
"Bernstein ML",
"Levy E."
],
"DOI_URL": null
},
"PUB00112136": {
"PMID": 2258921,
"ISBN": null,
"volume": "216",
"issue": "3",
"year": 1990,
"title": "Accuracy of DNA primase.",
"URL": null,
"raw_pages": "475-9",
"medline_journal": "J Mol Biol",
"ISO_journal": "J Mol Biol",
"authors": [
"Zhang SS",
"Grosse F."
],
"DOI_URL": null
},
"PUB00112146": {
"PMID": 9268648,
"ISBN": null,
"volume": "43",
"issue": "3",
"year": 1997,
"title": "Mapping of the human DNA primase 1 (PRIM1) to chromosome 12q13.",
"URL": null,
"raw_pages": "398-401",
"medline_journal": "Genomics",
"ISO_journal": "Genomics",
"authors": [
"Cloutier S",
"Hamel H",
"Champagne M",
"Yotov WV."
],
"DOI_URL": null
},
"PUB00044946": {
"PMID": 16027112,
"ISBN": null,
"volume": "33",
"issue": "12",
"year": 2005,
"title": "Origin and evolution of the archaeo-eukaryotic primase superfamily and related palm-domain proteins: structural insights and new members.",
"URL": null,
"raw_pages": "3875-96",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res.",
"authors": [
"Iyer LM",
"Koonin EV",
"Leipe DD",
"Aravind L."
],
"DOI_URL": "http://dx.doi.org/10.1093/nar/gki702"
},
"PUB00009771": {
"PMID": 10536154,
"ISBN": null,
"volume": "27",
"issue": "22",
"year": 1999,
"title": "Identification and characterization of a DNA primase from the hyperthermophilic archaeon Methanococcus jannaschii.",
"URL": null,
"raw_pages": "4444-50",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res.",
"authors": [
"Desogus G",
"Onesti S",
"Brick P",
"Rossi M",
"Pisani FM."
],
"DOI_URL": "http://dx.doi.org/10.1093/nar/27.22.4444"
},
"PUB00009837": {
"PMID": 8026492,
"ISBN": null,
"volume": "222",
"issue": "3",
"year": 1994,
"title": "DNA replication in vitro by recombinant DNA-polymerase-alpha-primase.",
"URL": null,
"raw_pages": "781-93",
"medline_journal": "Eur J Biochem",
"ISO_journal": "Eur. J. Biochem.",
"authors": [
"Stadlbauer F",
"Brueckner A",
"Rehfuess C",
"Eckerskorn C",
"Lottspeich F",
"Forster V",
"Tseng BY",
"Nasheuer HP."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1432-1033.1994.tb18925.x"
},
"PUB00112135": {
"PMID": 7681326,
"ISBN": null,
"volume": "32",
"issue": "12",
"year": 1993,
"title": "Mechanism of calf thymus DNA primase: slow initiation, rapid polymerization, and intelligent termination.",
"URL": null,
"raw_pages": "3027-37",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Sheaff RJ",
"Kuchta RD."
],
"DOI_URL": null
},
"PUB00112133": {
"PMID": 10433721,
"ISBN": null,
"volume": "38",
"issue": "31",
"year": 1999,
"title": "Human DNA primase: anion inhibition, manganese stimulation, and their effects on in vitro start-site selection.",
"URL": null,
"raw_pages": "10126-34",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Kirk BW",
"Kuchta RD."
],
"DOI_URL": null
},
"PUB00112124": {
"PMID": 11084371,
"ISBN": null,
"volume": "25",
"issue": "11",
"year": 2000,
"title": "Eukaryotic DNA primase.",
"URL": null,
"raw_pages": "572-6",
"medline_journal": "Trends Biochem Sci",
"ISO_journal": "Trends Biochem Sci",
"authors": [
"Arezi B",
"Kuchta RD."
],
"DOI_URL": null
},
"PUB00033236": {
"PMID": 11301257,
"ISBN": null,
"volume": "11",
"issue": "6",
"year": 2001,
"title": "Archaeal primase: bridging the gap between RNA and DNA polymerases.",
"URL": null,
"raw_pages": "452-6",
"medline_journal": "Curr Biol",
"ISO_journal": "Curr. Biol.",
"authors": [
"Bocquier AA",
"Liu L",
"Cann IK",
"Komori K",
"Kohda D",
"Ishino Y."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0960-9822(01)00119-1"
},
"PUB00112144": {
"PMID": 3313275,
"ISBN": null,
"volume": "15",
"issue": "19",
"year": 1987,
"title": "The nucleotide sequence of the PRI1 gene related to DNA primase in Saccharomyces cerevisiae.",
"URL": null,
"raw_pages": "7975-89",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res",
"authors": [
"Plevani P",
"Francesconi S",
"Lucchini G."
],
"DOI_URL": null
},
"PUB00112134": {
"PMID": 7876136,
"ISBN": null,
"volume": "270",
"issue": "8",
"year": 1995,
"title": "Active site mapping of the catalytic mouse primase subunit by alanine scanning mutagenesis.",
"URL": null,
"raw_pages": "3905-13",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Copeland WC",
"Tan X."
],
"DOI_URL": null
},
"PUB00112141": {
"PMID": 12138196,
"ISBN": null,
"volume": "22",
"issue": "16",
"year": 2002,
"title": "Interactions between telomerase and primase physically link the telomere and chromosome replication machinery.",
"URL": null,
"raw_pages": "5859-68",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol Cell Biol",
"authors": [
"Ray S",
"Karamysheva Z",
"Wang L",
"Shippen DE",
"Price CM."
],
"DOI_URL": null
},
"PUB00112125": {
"PMID": 16467299,
"ISBN": null,
"volume": "281",
"issue": "22",
"year": 2006,
"title": "The chromosome replication machinery of the archaeon Sulfolobus solfataricus.",
"URL": null,
"raw_pages": "15029-32",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Duggin IG",
"Bell SD."
],
"DOI_URL": null
},
"PUB00037913": {
"PMID": 14750947,
"ISBN": null,
"volume": "8",
"issue": "12",
"year": 2003,
"title": "Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis.",
"URL": null,
"raw_pages": "913-23",
"medline_journal": "Genes Cells",
"ISO_journal": "Genes Cells",
"authors": [
"Ito N",
"Nureki O",
"Shirouzu M",
"Yokoyama S",
"Hanaoka F."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1365-2443.2003.00693.x"
},
"PUB00112145": {
"PMID": 8530050,
"ISBN": null,
"volume": "28",
"issue": "2",
"year": 1995,
"title": "Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12.",
"URL": null,
"raw_pages": "350-3",
"medline_journal": "Genomics",
"ISO_journal": "Genomics",
"authors": [
"Shiratori A",
"Okumura K",
"Nogami M",
"Taguchi H",
"Onozaki T",
"Inoue T",
"Ando T",
"Shibata T",
"Izumi M",
"Miyazawa H."
],
"DOI_URL": null
},
"PUB00112142": {
"PMID": 12752433,
"ISBN": null,
"volume": "270",
"issue": "10",
"year": 2003,
"title": "Dissociation of DNA polymerase alpha-primase complex during meiosis in Coprinus cinereus.",
"URL": null,
"raw_pages": "2137-46",
"medline_journal": "Eur J Biochem",
"ISO_journal": "Eur J Biochem",
"authors": [
"Namekawa S",
"Hamada F",
"Sawado T",
"Ishii S",
"Nara T",
"Ishizaki T",
"Ohuchi T",
"Arai T",
"Sakaguchi K."
],
"DOI_URL": null
},
"PUB00112131": {
"PMID": 10387012,
"ISBN": null,
"volume": "38",
"issue": "24",
"year": 1999,
"title": "Arg304 of human DNA primase is a key contributor to catalysis and NTP binding: primase and the family X polymerases share significant sequence homology.",
"URL": null,
"raw_pages": "7727-36",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Kirk BW",
"Kuchta RD."
],
"DOI_URL": null
},
"PUB00112128": {
"PMID": 9034345,
"ISBN": null,
"volume": "16",
"issue": "3",
"year": 1997,
"title": "A role for DNA primase in coupling DNA replication to DNA damage response.",
"URL": null,
"raw_pages": "639-50",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J",
"authors": [
"Marini F",
"Pellicioli A",
"Paciotti V",
"Lucchini G",
"Plevani P",
"Stern DF",
"Foiani M."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl01287",
"name": "AE_Prim_S_like"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 4809,
"pathways": 0,
"proteins": 4808,
"proteomes": 3347,
"sets": 1,
"structural_models": {
"alphafold": 4320,
"bfvd": 0
},
"structures": 51,
"taxa": 9077
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "9f28",
"name": "Crystal structure of the heterodimeric primase from pyrococcus abyssi (deletion of the PriL-CTD domain)"
}
}
}
