"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"cd04860"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 4809, 'pathways': 0, 'proteins': 4808, 'proteomes': 3347, 'sets': 1, 'structural_models': {'alphafold': 4320, 'bfvd': 0}, 'structures': 51, 'taxa': 9077}"	"{}"	"[{'text': '<p>AE_Prim_S: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. Primases are DNA-dependent RNA polymerases which synthesis the short RNA primers required for DNA replication. In addition to its catalytic role in replication, DNA primase may play a role in coupling replication to DNA damage repair and in checkpoint control during S phase. In eukaryotes, this small catalytically active primase subunit (p50) and a larger primase subunit (p60), referred to jointly as the core primase, associate with the B subunit and the DNA polymerase alpha subunit in a complex, called Pol alpha-pri. The function of the larger primase subunit is unclear. Included in this group are Pfu41 and Pfu46, these two proteins comprise the primase complex of the archaea Pyrococcus furiosus; Pfu41 and Pfu46 have sequence identity to the eukaryotic p50 and p60 primase proteins respectively. Pfu41 preferentially uses dNTPs as substrate. Pfu46 regulates the primase activity of Pfu41. [[cite:PUB00005693], [cite:PUB00112128], [cite:PUB00039010], [cite:PUB00112129], [cite:PUB00112130], [cite:PUB00033236], [cite:PUB00037913], [cite:PUB00025150], [cite:PUB00070916], [cite:PUB00009771], [cite:PUB00112131], [cite:PUB00090446], [cite:PUB00112132], [cite:PUB00112133], [cite:PUB00112134], [cite:PUB00112135], [cite:PUB00112136], [cite:PUB00112137], [cite:PUB00112138], [cite:PUB00112139], [cite:PUB00112140], [cite:PUB00112141], [cite:PUB00112142], [cite:PUB00112143], [cite:PUB00112144], [cite:PUB00009837], [cite:PUB00112145], [cite:PUB00112146], [cite:PUB00044946], [cite:PUB00112125], [cite:PUB00112124], [cite:PUB00116964]]</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	"IPR014052"	False	False	False	"{'PUB00112139': {'PMID': 10504261, 'ISBN': None, 'volume': '38', 'issue': '39', 'year': 1999, 'title': 'Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit.', 'URL': None, 'raw_pages': '12899-907', 'medline_journal': 'Biochemistry', 'ISO_journal': 'Biochemistry', 'authors': ['Arezi B', 'Kirk BW', 'Copeland WC', 'Kuchta RD.'], 'DOI_URL': None}, 'PUB00070916': {'PMID': 12806117, 'ISBN': None, 'volume': '3', 'issue': None, 'year': 2003, 'title': 'The DNA polymerase alpha-primase complex: multiple functions and interactions.', 'URL': None, 'raw_pages': '21-33', 'medline_journal': 'ScientificWorldJournal', 'ISO_journal': 'ScientificWorldJournal', 'authors': ['Muzi-Falconi M', 'Giannattasio M', 'Foiani M', 'Plevani P.'], 'DOI_URL': 'http://dx.doi.org/10.1100/tsw.2003.05'}, 'PUB00112130': {'PMID': 11584001, 'ISBN': None, 'volume': '276', 'issue': '48', 'year': 2001, 'title': 'The archaeal DNA primase: biochemical characterization of the p41-p46 complex from Pyrococcus furiosus.', 'URL': None, 'raw_pages': '45484-90', 'medline_journal': 'J Biol Chem', 'ISO_journal': 'J Biol Chem', 'authors': ['Liu L', 'Komori K', 'Ishino S', 'Bocquier AA', 'Cann IK', 'Kohda D', 'Ishino Y.'], 'DOI_URL': None}, 'PUB00112140': {'PMID': 11917009, 'ISBN': None, 'volume': '30', 'issue': '7', 'year': 2002, 'title': 'Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase alpha-primase.', 'URL': None, 'raw_pages': '1493-9', 'medline_journal': 'Nucleic Acids Res', 'ISO_journal': 'Nucleic Acids Res', 'authors': ['Melle C', 'Nasheuer HP.'], 'DOI_URL': None}, 'PUB00112143': {'PMID': 3061469, 'ISBN': None, 'volume': '951', 'issue': '2-3', 'year': 1988, 'title': 'The yeast DNA polymerase-primase complex: genes and proteins.', 'URL': None, 'raw_pages': '268-73', 'medline_journal': 'Biochim Biophys Acta', 'ISO_journal': 'Biochim Biophys Acta', 'authors': ['Plevani P', 'Foiani M', 'Muzi Falconi M', 'Pizzagalli A', 'Santocanale C', 'Francesconi S', 'Valsasnini P', 'Comedini A', 'Piatti S', 'Lucchini G.'], 'DOI_URL': None}, 'PUB00112132': {'PMID': 14674773, 'ISBN': None, 'volume': '42', 'issue': '50', 'year': 2003, 'title': 'Distinct domain functions regulating de novo DNA synthesis of thermostable DNA primase from hyperthermophile Pyrococcus horikoshii.', 'URL': None, 'raw_pages': '14968-76', 'medline_journal': 'Biochemistry', 'ISO_journal': 'Biochemistry', 'authors': ['Matsui E', 'Nishio M', 'Yokoyama H', 'Harata K', 'Darnis S', 'Matsui I.'], 'DOI_URL': None}, 'PUB00112129': {'PMID': 16095750, 'ISBN': None, 'volume': '21', 'issue': '10', 'year': 2005, 'title': 'The promiscuous primase.', 'URL': None, 'raw_pages': '568-72', 'medline_journal': 'Trends Genet', 'ISO_journal': 'Trends Genet', 'authors': ['Lao-Sirieix SH', 'Pellegrini L', 'Bell SD.'], 'DOI_URL': None}, 'PUB00025150': {'PMID': 11135672, 'ISBN': None, 'volume': '8', 'issue': '1', 'year': 2001, 'title': 'Crystal structure of a DNA-dependent RNA polymerase (DNA primase).', 'URL': None, 'raw_pages': '57-61', 'medline_journal': 'Nat Struct Biol', 'ISO_journal': 'Nat. Struct. Biol.', 'authors': ['Augustin MA', 'Huber R', 'Kaiser JT.'], 'DOI_URL': 'http://dx.doi.org/10.1038/83060'}, 'PUB00039010': {'PMID': 16273105, 'ISBN': None, 'volume': '12', 'issue': '12', 'year': 2005, 'title': 'Structure of the heterodimeric core primase.', 'URL': None, 'raw_pages': '1137-44', 'medline_journal': 'Nat Struct Mol Biol', 'ISO_journal': 'Nat. Struct. Mol. Biol.', 'authors': ['Lao-Sirieix SH', 'Nookala RK', 'Roversi P', 'Bell SD', 'Pellegrini L.'], 'DOI_URL': 'http://dx.doi.org/10.1038/nsmb1013'}, 'PUB00090446': {'PMID': 15755447, 'ISBN': None, 'volume': '347', 'issue': '3', 'year': 2005, 'title': 'Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.', 'URL': None, 'raw_pages': '509-21', 'medline_journal': 'J Mol Biol', 'ISO_journal': 'J. Mol. Biol.', 'authors': ['Nedelcheva MN', 'Roguev A', 'Dolapchiev LB', 'Shevchenko A', 'Taskov HB', 'Shevchenko A', 'Stewart AF', 'Stoynov SS.'], 'DOI_URL': 'https://doi.org/10.1016/j.jmb.2005.01.041'}, 'PUB00005693': {'PMID': 2023935, 'ISBN': None, 'volume': '88', 'issue': '9', 'year': 1991, 'title': 'Mutations in conserved yeast DNA primase domains impair DNA replication in vivo.', 'URL': None, 'raw_pages': '3877-81', 'medline_journal': 'Proc Natl Acad Sci U S A', 'ISO_journal': 'Proc. Natl. Acad. Sci. U.S.A.', 'authors': ['Francesconi S', 'Longhese MP', 'Piseri A', 'Santocanale C', 'Lucchini G', 'Plevani P.'], 'DOI_URL': 'http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=2023935'}, 'PUB00112137': {'PMID': 9705292, 'ISBN': None, 'volume': '273', 'issue': '34', 'year': 1998, 'title': 'Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit.', 'URL': None, 'raw_pages': '21608-15', 'medline_journal': 'J Biol Chem', 'ISO_journal': 'J Biol Chem', 'authors': ['Schneider A', 'Smith RW', 'Kautz AR', 'Weisshart K', 'Grosse F', 'Nasheuer HP.'], 'DOI_URL': None}, 'PUB00116964': {'PMID': 11395402, 'ISBN': None, 'volume': '70', 'issue': None, 'year': 2001, 'title': 'DNA primases.', 'URL': None, 'raw_pages': '39-80', 'medline_journal': 'Annu Rev Biochem', 'ISO_journal': 'Annu Rev Biochem', 'authors': ['Frick DN', 'Richardson CC.'], 'DOI_URL': None}, 'PUB00112138': {'PMID': 10441007, 'ISBN': None, 'volume': '26', 'issue': '1', 'year': 1999, 'title': 'Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma.', 'URL': None, 'raw_pages': '62-9', 'medline_journal': 'Genes Chromosomes Cancer', 'ISO_journal': 'Genes Chromosomes Cancer', 'authors': ['Yotov WV', 'Hamel H', 'Rivard GE', 'Champagne MA', 'Russo PA', 'Leclerc JM', 'Bernstein ML', 'Levy E.'], 'DOI_URL': None}, 'PUB00112136': {'PMID': 2258921, 'ISBN': None, 'volume': '216', 'issue': '3', 'year': 1990, 'title': 'Accuracy of DNA primase.', 'URL': None, 'raw_pages': '475-9', 'medline_journal': 'J Mol Biol', 'ISO_journal': 'J Mol Biol', 'authors': ['Zhang SS', 'Grosse F.'], 'DOI_URL': None}, 'PUB00112146': {'PMID': 9268648, 'ISBN': None, 'volume': '43', 'issue': '3', 'year': 1997, 'title': 'Mapping of the human DNA primase 1 (PRIM1) to chromosome 12q13.', 'URL': None, 'raw_pages': '398-401', 'medline_journal': 'Genomics', 'ISO_journal': 'Genomics', 'authors': ['Cloutier S', 'Hamel H', 'Champagne M', 'Yotov WV.'], 'DOI_URL': None}, 'PUB00044946': {'PMID': 16027112, 'ISBN': None, 'volume': '33', 'issue': '12', 'year': 2005, 'title': 'Origin and evolution of the archaeo-eukaryotic primase superfamily and related palm-domain proteins: structural insights and new members.', 'URL': None, 'raw_pages': '3875-96', 'medline_journal': 'Nucleic Acids Res', 'ISO_journal': 'Nucleic Acids Res.', 'authors': ['Iyer LM', 'Koonin EV', 'Leipe DD', 'Aravind L.'], 'DOI_URL': 'http://dx.doi.org/10.1093/nar/gki702'}, 'PUB00009771': {'PMID': 10536154, 'ISBN': None, 'volume': '27', 'issue': '22', 'year': 1999, 'title': 'Identification and characterization of a DNA primase from the hyperthermophilic archaeon Methanococcus jannaschii.', 'URL': None, 'raw_pages': '4444-50', 'medline_journal': 'Nucleic Acids Res', 'ISO_journal': 'Nucleic Acids Res.', 'authors': ['Desogus G', 'Onesti S', 'Brick P', 'Rossi M', 'Pisani FM.'], 'DOI_URL': 'http://dx.doi.org/10.1093/nar/27.22.4444'}, 'PUB00009837': {'PMID': 8026492, 'ISBN': None, 'volume': '222', 'issue': '3', 'year': 1994, 'title': 'DNA replication in vitro by recombinant DNA-polymerase-alpha-primase.', 'URL': None, 'raw_pages': '781-93', 'medline_journal': 'Eur J Biochem', 'ISO_journal': 'Eur. J. Biochem.', 'authors': ['Stadlbauer F', 'Brueckner A', 'Rehfuess C', 'Eckerskorn C', 'Lottspeich F', 'Forster V', 'Tseng BY', 'Nasheuer HP.'], 'DOI_URL': 'http://dx.doi.org/10.1111/j.1432-1033.1994.tb18925.x'}, 'PUB00112135': {'PMID': 7681326, 'ISBN': None, 'volume': '32', 'issue': '12', 'year': 1993, 'title': 'Mechanism of calf thymus DNA primase: slow initiation, rapid polymerization, and intelligent termination.', 'URL': None, 'raw_pages': '3027-37', 'medline_journal': 'Biochemistry', 'ISO_journal': 'Biochemistry', 'authors': ['Sheaff RJ', 'Kuchta RD.'], 'DOI_URL': None}, 'PUB00112133': {'PMID': 10433721, 'ISBN': None, 'volume': '38', 'issue': '31', 'year': 1999, 'title': 'Human DNA primase: anion inhibition, manganese stimulation, and their effects on in vitro start-site selection.', 'URL': None, 'raw_pages': '10126-34', 'medline_journal': 'Biochemistry', 'ISO_journal': 'Biochemistry', 'authors': ['Kirk BW', 'Kuchta RD.'], 'DOI_URL': None}, 'PUB00112124': {'PMID': 11084371, 'ISBN': None, 'volume': '25', 'issue': '11', 'year': 2000, 'title': 'Eukaryotic DNA primase.', 'URL': None, 'raw_pages': '572-6', 'medline_journal': 'Trends Biochem Sci', 'ISO_journal': 'Trends Biochem Sci', 'authors': ['Arezi B', 'Kuchta RD.'], 'DOI_URL': None}, 'PUB00033236': {'PMID': 11301257, 'ISBN': None, 'volume': '11', 'issue': '6', 'year': 2001, 'title': 'Archaeal primase: bridging the gap between RNA and DNA polymerases.', 'URL': None, 'raw_pages': '452-6', 'medline_journal': 'Curr Biol', 'ISO_journal': 'Curr. Biol.', 'authors': ['Bocquier AA', 'Liu L', 'Cann IK', 'Komori K', 'Kohda D', 'Ishino Y.'], 'DOI_URL': 'http://dx.doi.org/10.1016/S0960-9822(01)00119-1'}, 'PUB00112144': {'PMID': 3313275, 'ISBN': None, 'volume': '15', 'issue': '19', 'year': 1987, 'title': 'The nucleotide sequence of the PRI1 gene related to DNA primase in Saccharomyces cerevisiae.', 'URL': None, 'raw_pages': '7975-89', 'medline_journal': 'Nucleic Acids Res', 'ISO_journal': 'Nucleic Acids Res', 'authors': ['Plevani P', 'Francesconi S', 'Lucchini G.'], 'DOI_URL': None}, 'PUB00112134': {'PMID': 7876136, 'ISBN': None, 'volume': '270', 'issue': '8', 'year': 1995, 'title': 'Active site mapping of the catalytic mouse primase subunit by alanine scanning mutagenesis.', 'URL': None, 'raw_pages': '3905-13', 'medline_journal': 'J Biol Chem', 'ISO_journal': 'J Biol Chem', 'authors': ['Copeland WC', 'Tan X.'], 'DOI_URL': None}, 'PUB00112141': {'PMID': 12138196, 'ISBN': None, 'volume': '22', 'issue': '16', 'year': 2002, 'title': 'Interactions between telomerase and primase physically link the telomere and chromosome replication machinery.', 'URL': None, 'raw_pages': '5859-68', 'medline_journal': 'Mol Cell Biol', 'ISO_journal': 'Mol Cell Biol', 'authors': ['Ray S', 'Karamysheva Z', 'Wang L', 'Shippen DE', 'Price CM.'], 'DOI_URL': None}, 'PUB00112125': {'PMID': 16467299, 'ISBN': None, 'volume': '281', 'issue': '22', 'year': 2006, 'title': 'The chromosome replication machinery of the archaeon Sulfolobus solfataricus.', 'URL': None, 'raw_pages': '15029-32', 'medline_journal': 'J Biol Chem', 'ISO_journal': 'J Biol Chem', 'authors': ['Duggin IG', 'Bell SD.'], 'DOI_URL': None}, 'PUB00037913': {'PMID': 14750947, 'ISBN': None, 'volume': '8', 'issue': '12', 'year': 2003, 'title': 'Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis.', 'URL': None, 'raw_pages': '913-23', 'medline_journal': 'Genes Cells', 'ISO_journal': 'Genes Cells', 'authors': ['Ito N', 'Nureki O', 'Shirouzu M', 'Yokoyama S', 'Hanaoka F.'], 'DOI_URL': 'http://dx.doi.org/10.1111/j.1365-2443.2003.00693.x'}, 'PUB00112145': {'PMID': 8530050, 'ISBN': None, 'volume': '28', 'issue': '2', 'year': 1995, 'title': 'Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12.', 'URL': None, 'raw_pages': '350-3', 'medline_journal': 'Genomics', 'ISO_journal': 'Genomics', 'authors': ['Shiratori A', 'Okumura K', 'Nogami M', 'Taguchi H', 'Onozaki T', 'Inoue T', 'Ando T', 'Shibata T', 'Izumi M', 'Miyazawa H.'], 'DOI_URL': None}, 'PUB00112142': {'PMID': 12752433, 'ISBN': None, 'volume': '270', 'issue': '10', 'year': 2003, 'title': 'Dissociation of DNA polymerase alpha-primase complex during meiosis in Coprinus cinereus.', 'URL': None, 'raw_pages': '2137-46', 'medline_journal': 'Eur J Biochem', 'ISO_journal': 'Eur J Biochem', 'authors': ['Namekawa S', 'Hamada F', 'Sawado T', 'Ishii S', 'Nara T', 'Ishizaki T', 'Ohuchi T', 'Arai T', 'Sakaguchi K.'], 'DOI_URL': None}, 'PUB00112131': {'PMID': 10387012, 'ISBN': None, 'volume': '38', 'issue': '24', 'year': 1999, 'title': 'Arg304 of human DNA primase is a key contributor to catalysis and NTP binding: primase and the family X polymerases share significant sequence homology.', 'URL': None, 'raw_pages': '7727-36', 'medline_journal': 'Biochemistry', 'ISO_journal': 'Biochemistry', 'authors': ['Kirk BW', 'Kuchta RD.'], 'DOI_URL': None}, 'PUB00112128': {'PMID': 9034345, 'ISBN': None, 'volume': '16', 'issue': '3', 'year': 1997, 'title': 'A role for DNA primase in coupling DNA replication to DNA damage response.', 'URL': None, 'raw_pages': '639-50', 'medline_journal': 'EMBO J', 'ISO_journal': 'EMBO J', 'authors': ['Marini F', 'Pellicioli A', 'Paciotti V', 'Lucchini G', 'Plevani P', 'Stern DF', 'Foiani M.'], 'DOI_URL': None}}"	""	"{'name': None, 'short': 'AE_Prim_S'}"	""	"{'accession': '9f28', 'name': 'Crystal structure of the heterodimeric primase from pyrococcus abyssi (deletion of the PriL-CTD domain)'}"	"{'accession': 'cl01287', 'name': 'AE_Prim_S_like'}"	"cdd"	"domain"	""