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{
"metadata": {
"accession": "IPR056631",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF23053": "N4BP1, UBA-like domain"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR056631",
"name": "N4BP1, UBA-like domain",
"type": "Domain",
"children": []
},
"name": {
"name": "N4BP1, UBA-like domain",
"short": "UBA_N4BP1"
},
"description": [
{
"text": "<p>This domain is found in the human NEDD4-binding protein 1 (N4BP1) and related proteins. It has a significant sequence and structural similarity to UBA domains. This domain is predicted to adopt a globular structure consisting of a three helical bundle.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>N4BP1 is a potent suppressor of cytokine production that acts as a regulator of innate immune signalling and inflammation [[cite:PUB00159024]]. It acts as a restriction factor against some viruses, such as HIV-1. N4BP1 restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity [[cite:PUB00101187]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00101187": {
"PMID": 31133753,
"ISBN": null,
"volume": "4",
"issue": "9",
"year": 2019,
"title": "N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation.",
"URL": null,
"raw_pages": "1532-1544",
"medline_journal": "Nat Microbiol",
"ISO_journal": "Nat Microbiol",
"authors": [
"Yamasoba D",
"Sato K",
"Ichinose T",
"Imamura T",
"Koepke L",
"Joas S",
"Reith E",
"Hotter D",
"Misawa N",
"Akaki K",
"Uehata T",
"Mino T",
"Miyamoto S",
"Noda T",
"Yamashita A",
"Standley DM",
"Kirchhoff F",
"Sauter D",
"Koyanagi Y",
"Takeuchi O."
],
"DOI_URL": null
},
"PUB00159024": {
"PMID": 32971525,
"ISBN": null,
"volume": "587",
"issue": "7833",
"year": 2020,
"title": "Integration of innate immune signalling by caspase-8 cleavage of N4BP1.",
"URL": null,
"raw_pages": "275-280",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Gitlin AD",
"Heger K",
"Schubert AF",
"Reja R",
"Yan D",
"Pham VC",
"Suto E",
"Zhang J",
"Kwon YC",
"Freund EC",
"Kang J",
"Pham A",
"Caothien R",
"Bacarro N",
"Hinkle T",
"Xu M",
"McKenzie BS",
"Haley B",
"Lee WP",
"Lill JR",
"Roose-Girma M",
"Dohse M",
"Webster JD",
"Newton K",
"Dixit VM."
],
"DOI_URL": "https://doi.org/10.1038/s41586-020-2796-5"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 35,
"interactions": 0,
"matches": 876,
"pathways": 4,
"proteins": 874,
"proteomes": 388,
"sets": 0,
"structural_models": {
"alphafold": 786,
"bfvd": 0
},
"structures": 0,
"taxa": 1345
},
"entry_annotations": {
"alignment:seed": 21,
"alignment:full": 595
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
