{"metadata":{"accession":"IPR056631","entry_id":null,"type":"domain","go_terms":null,"source_database":"interpro","member_databases":{"pfam":{"PF23053":"N4BP1, UBA-like domain"}},"integrated":null,"hierarchy":{"accession":"IPR056631","name":"N4BP1, UBA-like domain","type":"Domain","children":[]},"name":{"name":"N4BP1, UBA-like domain","short":"UBA_N4BP1"},"description":[{"text":"<p>This domain is found in the human NEDD4-binding protein 1 (N4BP1) and related proteins. It has a significant sequence and structural similarity to UBA domains. This domain is predicted to adopt a globular structure consisting of a three helical bundle.</p>","llm":false,"checked":false,"updated":false},{"text":"<p>N4BP1 is a potent suppressor of cytokine production that acts as a regulator of innate immune signalling and inflammation [[cite:PUB00159024]]. It acts as a restriction factor against some viruses, such as HIV-1. N4BP1 restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity [[cite:PUB00101187]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00101187":{"PMID":31133753,"ISBN":null,"volume":"4","issue":"9","year":2019,"title":"N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation.","URL":null,"raw_pages":"1532-1544","medline_journal":"Nat Microbiol","ISO_journal":"Nat Microbiol","authors":["Yamasoba D","Sato K","Ichinose T","Imamura T","Koepke L","Joas S","Reith E","Hotter D","Misawa N","Akaki K","Uehata T","Mino T","Miyamoto S","Noda T","Yamashita A","Standley DM","Kirchhoff F","Sauter D","Koyanagi Y","Takeuchi O."],"DOI_URL":null},"PUB00159024":{"PMID":32971525,"ISBN":null,"volume":"587","issue":"7833","year":2020,"title":"Integration of innate immune signalling by caspase-8 cleavage of N4BP1.","URL":null,"raw_pages":"275-280","medline_journal":"Nature","ISO_journal":"Nature","authors":["Gitlin AD","Heger K","Schubert AF","Reja R","Yan D","Pham VC","Suto E","Zhang J","Kwon YC","Freund EC","Kang J","Pham A","Caothien R","Bacarro N","Hinkle T","Xu M","McKenzie BS","Haley B","Lee WP","Lill JR","Roose-Girma M","Dohse M","Webster JD","Newton K","Dixit VM."],"DOI_URL":"https://doi.org/10.1038/s41586-020-2796-5"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":35,"interactions":0,"matches":876,"pathways":4,"proteins":874,"proteomes":388,"sets":0,"structural_models":{"alphafold":786,"bfvd":0},"structures":0,"taxa":1345},"entry_annotations":{"alignment:seed":21,"alignment:full":595},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}