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{
    "metadata": {
        "accession": "IPR056363",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF23211": "Leucine-rich repeat and WD repeat-containing protein 1, LRR"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR056363",
            "name": "Leucine-rich repeat and WD repeat-containing protein 1, LRR domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Leucine-rich repeat and WD repeat-containing protein 1, LRR domain",
            "short": "LRR_LRWD1_dom"
        },
        "description": [
            {
                "text": "<p>This entry represents the Leucine-rich repeat domain found at the N terminus of Leucine-rich repeat and WD repeat-containing protein 1 (LRWD1) from animals and related sequences.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            },
            {
                "text": "<p>LRWD1 (also known as CENP-33 and ORCA) is required for for G1/S transition. It recruits and stabilises the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in pre-replicated cells [[cite:PUB00155714], [cite:PUB00155715], [cite:PUB00155716]]. This proteins consist of a LRR domain at the N terminus and a WD domain at the C terminus.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00155714": {
                "PMID": 20932478,
                "ISBN": null,
                "volume": "40",
                "issue": "1",
                "year": 2010,
                "title": "A WD-repeat protein stabilizes ORC binding to chromatin.",
                "URL": null,
                "raw_pages": "99-111",
                "medline_journal": "Mol Cell",
                "ISO_journal": "Mol Cell",
                "authors": [
                    "Shen Z",
                    "Sathyan KM",
                    "Geng Y",
                    "Zheng R",
                    "Chakraborty A",
                    "Freeman B",
                    "Wang F",
                    "Prasanth KV",
                    "Prasanth SG."
                ],
                "DOI_URL": "https://doi.org/10.1016/j.molcel.2010.09.021"
            },
            "PUB00155715": {
                "PMID": 22427655,
                "ISBN": null,
                "volume": "287",
                "issue": "18",
                "year": 2012,
                "title": "Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.",
                "URL": null,
                "raw_pages": "15024-33",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J Biol Chem",
                "authors": [
                    "Chan KM",
                    "Zhang Z."
                ],
                "DOI_URL": "https://doi.org/10.1074/jbc.M111.337980"
            },
            "PUB00155716": {
                "PMID": 22645314,
                "ISBN": null,
                "volume": "32",
                "issue": "15",
                "year": 2012,
                "title": "Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation.",
                "URL": null,
                "raw_pages": "3107-20",
                "medline_journal": "Mol Cell Biol",
                "ISO_journal": "Mol Cell Biol",
                "authors": [
                    "Shen Z",
                    "Chakraborty A",
                    "Jain A",
                    "Giri S",
                    "Ha T",
                    "Prasanth KV",
                    "Prasanth SG."
                ],
                "DOI_URL": "https://doi.org/10.1128/MCB.00362-12"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR032675",
                "name": "Leucine-rich repeat domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 104,
            "interactions": 0,
            "matches": 1261,
            "pathways": 0,
            "proteins": 1257,
            "proteomes": 830,
            "sets": 0,
            "structural_models": {
                "alphafold": 1107,
                "bfvd": 0
            },
            "structures": 1,
            "taxa": 2954
        },
        "entry_annotations": {
            "alignment:seed": 1,
            "alignment:full": 910
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}