"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"IPR056363"	"{'subfamilies': 0, 'domain_architectures': 104, 'interactions': 0, 'matches': 1261, 'pathways': 0, 'proteins': 1257, 'proteomes': 830, 'sets': 0, 'structural_models': {'alphafold': 1107, 'bfvd': 0}, 'structures': 1, 'taxa': 2954}"	"{}"	"[{'text': '<p>This entry represents the Leucine-rich repeat domain found at the N terminus of Leucine-rich repeat and WD repeat-containing protein 1 (LRWD1) from animals and related sequences.</p>', 'llm': False, 'checked': False, 'updated': False}, {'text': '<p>LRWD1 (also known as CENP-33 and ORCA) is required for for G1/S transition. It recruits and stabilises the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in pre-replicated cells [[cite:PUB00155714], [cite:PUB00155715], [cite:PUB00155716]]. This proteins consist of a LRR domain at the N terminus and a WD domain at the C terminus.</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	"{'accession': 'IPR056363', 'name': 'Leucine-rich repeat and WD repeat-containing protein 1, LRR domain', 'type': 'Domain', 'children': []}"	""	False	False	False	"{'PUB00155714': {'PMID': 20932478, 'ISBN': None, 'volume': '40', 'issue': '1', 'year': 2010, 'title': 'A WD-repeat protein stabilizes ORC binding to chromatin.', 'URL': None, 'raw_pages': '99-111', 'medline_journal': 'Mol Cell', 'ISO_journal': 'Mol Cell', 'authors': ['Shen Z', 'Sathyan KM', 'Geng Y', 'Zheng R', 'Chakraborty A', 'Freeman B', 'Wang F', 'Prasanth KV', 'Prasanth SG.'], 'DOI_URL': 'https://doi.org/10.1016/j.molcel.2010.09.021'}, 'PUB00155715': {'PMID': 22427655, 'ISBN': None, 'volume': '287', 'issue': '18', 'year': 2012, 'title': 'Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.', 'URL': None, 'raw_pages': '15024-33', 'medline_journal': 'J Biol Chem', 'ISO_journal': 'J Biol Chem', 'authors': ['Chan KM', 'Zhang Z.'], 'DOI_URL': 'https://doi.org/10.1074/jbc.M111.337980'}, 'PUB00155716': {'PMID': 22645314, 'ISBN': None, 'volume': '32', 'issue': '15', 'year': 2012, 'title': 'Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation.', 'URL': None, 'raw_pages': '3107-20', 'medline_journal': 'Mol Cell Biol', 'ISO_journal': 'Mol Cell Biol', 'authors': ['Shen Z', 'Chakraborty A', 'Jain A', 'Giri S', 'Ha T', 'Prasanth KV', 'Prasanth SG.'], 'DOI_URL': 'https://doi.org/10.1128/MCB.00362-12'}}"	"{'pfam': {'PF23211': 'Leucine-rich repeat and WD repeat-containing protein 1, LRR'}}"	"{'name': 'Leucine-rich repeat and WD repeat-containing protein 1, LRR domain', 'short': 'LRR_LRWD1_dom'}"	"[{'accession': 'IPR032675', 'name': 'Leucine-rich repeat domain superfamily', 'type': 'homologous_superfamily'}]"	""	""	"interpro"	"domain"	""