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{
    "metadata": {
        "accession": "IPR042510",
        "entry_id": null,
        "type": "family",
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        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR23161": "PROTEIN CIP2A"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR042510",
            "name": "Protein CIP2A",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Protein CIP2A",
            "short": "CIP2A"
        },
        "description": [
            {
                "text": "<p>Cancerous inhibitor of PP2A (CIP2A) functions via protein binding through interactions with many other proteins including MYC, polo like kinase (PLK1) and NIMA protein. It is an inhibitor of PP2A, a tumour suppressor. CIP2A binds to PP2A and inhibits its phosphatase functions resulting in tumorigenic transformation of cells [[cite:PUB00093048], [cite:PUB00093049]]. CIP2A is overexpressed at a high frequency in a number of tumours and expression levels are independent markers for long-term outcomes in many of these tumours [[cite:PUB00093049]].</p>",
                "llm": false,
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        "wikipedia": null,
        "literature": {
            "PUB00093048": {
                "PMID": 17632056,
                "ISBN": null,
                "volume": "130",
                "issue": "1",
                "year": 2007,
                "title": "CIP2A inhibits PP2A in human malignancies.",
                "URL": null,
                "raw_pages": "51-62",
                "medline_journal": "Cell",
                "ISO_journal": "Cell",
                "authors": [
                    "Junttila MR",
                    "Puustinen P",
                    "Niemela M",
                    "Ahola R",
                    "Arnold H",
                    "Bottzauw T",
                    "Ala-aho R",
                    "Nielsen C",
                    "Ivaska J",
                    "Taya Y",
                    "Lu SL",
                    "Lin S",
                    "Chan EK",
                    "Wang XJ",
                    "Grenman R",
                    "Kast J",
                    "Kallunki T",
                    "Sears R",
                    "Kahari VM",
                    "Westermarck J."
                ],
                "DOI_URL": null
            },
            "PUB00093049": {
                "PMID": 25015035,
                "ISBN": null,
                "volume": "5",
                "issue": "13",
                "year": 2014,
                "title": "Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): an oncoprotein with many hands.",
                "URL": null,
                "raw_pages": "4581-602",
                "medline_journal": "Oncotarget",
                "ISO_journal": "Oncotarget",
                "authors": [
                    "De P",
                    "Carlson J",
                    "Leyland-Jones B",
                    "Dey N."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 1846,
            "pathways": 0,
            "proteins": 1846,
            "proteomes": 1152,
            "sets": 0,
            "structural_models": {
                "alphafold": 1693,
                "bfvd": 0
            },
            "structures": 1,
            "taxa": 3861
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}