{"metadata":{"accession":"IPR042510","entry_id":null,"type":"family","go_terms":null,"source_database":"interpro","member_databases":{"panther":{"PTHR23161":"PROTEIN CIP2A"}},"integrated":null,"hierarchy":{"accession":"IPR042510","name":"Protein CIP2A","type":"Family","children":[]},"name":{"name":"Protein CIP2A","short":"CIP2A"},"description":[{"text":"<p>Cancerous inhibitor of PP2A (CIP2A) functions via protein binding through interactions with many other proteins including MYC, polo like kinase (PLK1) and NIMA protein. It is an inhibitor of PP2A, a tumour suppressor. CIP2A binds to PP2A and inhibits its phosphatase functions resulting in tumorigenic transformation of cells [[cite:PUB00093048], [cite:PUB00093049]]. CIP2A is overexpressed at a high frequency in a number of tumours and expression levels are independent markers for long-term outcomes in many of these tumours [[cite:PUB00093049]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00093048":{"PMID":17632056,"ISBN":null,"volume":"130","issue":"1","year":2007,"title":"CIP2A inhibits PP2A in human malignancies.","URL":null,"raw_pages":"51-62","medline_journal":"Cell","ISO_journal":"Cell","authors":["Junttila MR","Puustinen P","Niemela M","Ahola R","Arnold H","Bottzauw T","Ala-aho R","Nielsen C","Ivaska J","Taya Y","Lu SL","Lin S","Chan EK","Wang XJ","Grenman R","Kast J","Kallunki T","Sears R","Kahari VM","Westermarck J."],"DOI_URL":null},"PUB00093049":{"PMID":25015035,"ISBN":null,"volume":"5","issue":"13","year":2014,"title":"Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): an oncoprotein with many hands.","URL":null,"raw_pages":"4581-602","medline_journal":"Oncotarget","ISO_journal":"Oncotarget","authors":["De P","Carlson J","Leyland-Jones B","Dey N."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":1846,"pathways":0,"proteins":1846,"proteomes":1152,"sets":0,"structural_models":{"alphafold":1693,"bfvd":0},"structures":1,"taxa":3861},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}