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{
    "metadata": {
        "accession": "IPR042239",
        "entry_id": null,
        "type": "homologous_superfamily",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "cathgene3d": {
                "G3DSA:1.10.246.90": "Nop domain"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR042239",
            "name": "Nop, C-terminal domain",
            "type": "Homologous_superfamily",
            "children": []
        },
        "name": {
            "name": "Nop, C-terminal domain",
            "short": "Nop_C"
        },
        "description": [
            {
                "text": "<p>The Nop domain is present in various pre-RNA processing ribonucleoproteins (RNP):</p>\n\n<ul>\n\n<li>Eukaryotic Prp31, part of a tri-snRNP complex. It is involved in pre-mRNA splicing.</li>\n<li>Eukaryotic Nucleolar proteins 56 and 58 (Nop56 and Nop58), components of box C/D small nucleolar ribonucleoprotein (snoRNP) particles.</li>\n<li>Archaeal Nop5, an homologue of Nop56/Nop58.</li></ul>\n\n<p>The Nop domain is a RNP binding module, exhibiting RNA and protein binding surfaces. It is oval-shaped and exclusively α-helical [[cite:PUB00027813], [cite:PUB00062919]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            },
            {
                "text": "<p>This entry represents the C-terminal part of the Nop domain.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00027813": {
                "PMID": 12598892,
                "ISBN": null,
                "volume": "10",
                "issue": "4",
                "year": 2003,
                "title": "Structure and function of archaeal box C/D sRNP core proteins.",
                "URL": null,
                "raw_pages": "256-63",
                "medline_journal": "Nat Struct Biol",
                "ISO_journal": "Nat. Struct. Biol.",
                "authors": [
                    "Aittaleb M",
                    "Rashid R",
                    "Chen Q",
                    "Palmer JR",
                    "Daniels CJ",
                    "Li H."
                ],
                "DOI_URL": "http://dx.doi.org/10.1038/nsb905"
            },
            "PUB00062919": {
                "PMID": 17412961,
                "ISBN": null,
                "volume": "316",
                "issue": "5821",
                "year": 2007,
                "title": "Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP.",
                "URL": null,
                "raw_pages": "115-20",
                "medline_journal": "Science",
                "ISO_journal": "Science",
                "authors": [
                    "Liu S",
                    "Li P",
                    "Dybkov O",
                    "Nottrott S",
                    "Hartmuth K",
                    "Luhrmann R",
                    "Carlomagno T",
                    "Wahl MC."
                ],
                "DOI_URL": "http://dx.doi.org/10.1126/science.1137924"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR036070",
                "name": "Nop domain superfamily",
                "type": "homologous_superfamily"
            },
            {
                "accession": "IPR002687",
                "name": "Nop domain",
                "type": "domain"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 16567,
            "pathways": 17,
            "proteins": 16507,
            "proteomes": 3964,
            "sets": 0,
            "structural_models": {
                "alphafold": 14891,
                "bfvd": 0
            },
            "structures": 102,
            "taxa": 12539
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}