{"metadata":{"accession":"IPR042239","entry_id":null,"type":"homologous_superfamily","go_terms":null,"source_database":"interpro","member_databases":{"cathgene3d":{"G3DSA:1.10.246.90":"Nop domain"}},"integrated":null,"hierarchy":{"accession":"IPR042239","name":"Nop, C-terminal domain","type":"Homologous_superfamily","children":[]},"name":{"name":"Nop, C-terminal domain","short":"Nop_C"},"description":[{"text":"<p>The Nop domain is present in various pre-RNA processing ribonucleoproteins (RNP):</p>\n\n<ul>\n\n<li>Eukaryotic Prp31, part of a tri-snRNP complex. It is involved in pre-mRNA splicing.</li>\n<li>Eukaryotic Nucleolar proteins 56 and 58 (Nop56 and Nop58), components of box C/D small nucleolar ribonucleoprotein (snoRNP) particles.</li>\n<li>Archaeal Nop5, an homologue of Nop56/Nop58.</li></ul>\n\n<p>The Nop domain is a RNP binding module, exhibiting RNA and protein binding surfaces. It is oval-shaped and exclusively α-helical [[cite:PUB00027813], [cite:PUB00062919]].</p>","llm":false,"checked":false,"updated":false},{"text":"<p>This entry represents the C-terminal part of the Nop domain.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00027813":{"PMID":12598892,"ISBN":null,"volume":"10","issue":"4","year":2003,"title":"Structure and function of archaeal box C/D sRNP core proteins.","URL":null,"raw_pages":"256-63","medline_journal":"Nat Struct Biol","ISO_journal":"Nat. Struct. Biol.","authors":["Aittaleb M","Rashid R","Chen Q","Palmer JR","Daniels CJ","Li H."],"DOI_URL":"http://dx.doi.org/10.1038/nsb905"},"PUB00062919":{"PMID":17412961,"ISBN":null,"volume":"316","issue":"5821","year":2007,"title":"Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP.","URL":null,"raw_pages":"115-20","medline_journal":"Science","ISO_journal":"Science","authors":["Liu S","Li P","Dybkov O","Nottrott S","Hartmuth K","Luhrmann R","Carlomagno T","Wahl MC."],"DOI_URL":"http://dx.doi.org/10.1126/science.1137924"}},"set_info":null,"overlaps_with":[{"accession":"IPR036070","name":"Nop domain superfamily","type":"homologous_superfamily"},{"accession":"IPR002687","name":"Nop domain","type":"domain"}],"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":16567,"pathways":17,"proteins":16507,"proteomes":3964,"sets":0,"structural_models":{"alphafold":14891,"bfvd":0},"structures":102,"taxa":12539},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}