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{
"metadata": {
"accession": "IPR042216",
"entry_id": null,
"type": "homologous_superfamily",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cathgene3d": {
"G3DSA:3.40.5.90": "CDGSH iron-sulfur domain, mitoNEET-type"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR042216",
"name": "MitoNEET, CDGSH iron-sulfur domain",
"type": "Homologous_superfamily",
"children": []
},
"name": {
"name": "MitoNEET, CDGSH iron-sulfur domain",
"short": "MitoNEET_CISD"
},
"description": [
{
"text": "<p>CDGSH iron-sulfur domains (CISDs) are classified into seven major types and are widely distributed throughout the three domains of life [[cite:PUB00056986]]. This superfamily represents the C-terminal domain found in the human CISD protein mitoNEET, also designated CSD1, an iron-containing integral protein of the outer mitochondrial membrane (OMM). MitoNEET contains two domains: a β-cap region and a cluster-binding domain, containing the CDGSH motif, that coordinates two acid-labile 2Fe-2S clusters (one bound to each protomer) [[cite:PUB00042908]]. The CDGSH iron-sulphur domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates [[cite:PUB00044559], [cite:PUB00042908]]. The whole protein regulates oxidative capacity and might be involved in electron transfer.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00056986": {
"PMID": 21949752,
"ISBN": null,
"volume": "6",
"issue": "9",
"year": 2011,
"title": "Structure and molecular evolution of CDGSH iron-sulfur domains.",
"URL": null,
"raw_pages": "e24790",
"medline_journal": "PLoS One",
"ISO_journal": "PLoS ONE",
"authors": [
"Lin J",
"Zhang L",
"Lai S",
"Ye K."
],
"DOI_URL": "http://dx.doi.org/10.1371/journal.pone.0024790"
},
"PUB00042908": {
"PMID": 17766440,
"ISBN": null,
"volume": "104",
"issue": "36",
"year": 2007,
"title": "MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone.",
"URL": null,
"raw_pages": "14342-7",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Paddock ML",
"Wiley SE",
"Axelrod HL",
"Cohen AE",
"Roy M",
"Abresch EC",
"Capraro D",
"Murphy AN",
"Nechushtai R",
"Dixon JE",
"Jennings PA."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.0707189104"
},
"PUB00044559": {
"PMID": 17584744,
"ISBN": null,
"volume": "282",
"issue": "33",
"year": 2007,
"title": "The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster.",
"URL": null,
"raw_pages": "23745-9",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Wiley SE",
"Paddock ML",
"Abresch EC",
"Gross L",
"van der Geer P",
"Nechushtai R",
"Murphy AN",
"Jennings PA",
"Dixon JE."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.C700107200"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR018967",
"name": "Iron-binding zinc finger, CDGSH type",
"type": "domain"
},
{
"accession": "IPR017123",
"name": "Uncharacterised conserved protein UCP037159",
"type": "family"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 17308,
"pathways": 0,
"proteins": 13240,
"proteomes": 7357,
"sets": 0,
"structural_models": {
"alphafold": 10634,
"bfvd": 2
},
"structures": 32,
"taxa": 15063
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "3tbo",
"name": "Crystal structure of a type 3 CDGSH iron-sulfur protein."
}
}
}
