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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR042068",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0030215",
"name": "semaphorin receptor binding",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd11237": "The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A)"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001627",
"name": "Sema domain",
"type": "Domain",
"children": [
{
"accession": "IPR015513",
"name": "Semaphorin 3E, Sema domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR039413",
"name": "RON, Sema domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041853",
"name": "Plexin-C1, Sema domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042068",
"name": "Semaphorin-1A, sema domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042582",
"name": "Semaphorin-3D, Sema domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042719",
"name": "Plexin-D1, sema domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042744",
"name": "Plexin-A1, Sema domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042820",
"name": "Semaphorin-3A, sema domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042821",
"name": "Semaphorin-5A, sema domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042824",
"name": "Semaphorin-7A, sema domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042826",
"name": "Plexin-A2, sema domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047085",
"name": "Semaphorin 4F, Sema domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR048224",
"name": "Semaphorin 5C, Sema domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Semaphorin-1A, sema domain",
"short": "SEM1A_sema_dom"
},
"description": [
{
"text": "<p>This entry represents the Sema domain found in Sema1A, which is a transmembrane protein. Sema1A binds to its receptor plexin A (PlexA), which in turn triggers downstream signaling events involving the receptor tyrosine kinase Otk, the evolutionarily conserved flavoprotein monooxygenase molecule interacting with CasL (MICAL), and the A kinase anchoring protein Nervy, leading to repulsive growth-cone response [[cite:PUB00092465], [cite:PUB00074782], [cite:PUB00043640]]. Sema1A has also been shown to be involved in synaptic formation [[cite:PUB00092464]].</p>\r\n\r\n<p>Sema1A belongs to the semaphorin family, whose members are regulatory molecules in the development of the nervous system and in axonal guidance [[cite:PUB00091974]]. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer [[cite:PUB00063292]]. The Sema domain is located at the N terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module [[cite:PUB00091404]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00063292": {
"PMID": 16584533,
"ISBN": null,
"volume": "7",
"issue": "3",
"year": 2006,
"title": "The semaphorins.",
"URL": null,
"raw_pages": "211",
"medline_journal": "Genome Biol",
"ISO_journal": "Genome Biol.",
"authors": [
"Yazdani U",
"Terman JR."
],
"DOI_URL": "http://dx.doi.org/10.1186/gb-2006-7-3-211"
},
"PUB00091404": {
"PMID": 20877282,
"ISBN": null,
"volume": "467",
"issue": "7319",
"year": 2010,
"title": "Structural basis of semaphorin-plexin signalling.",
"URL": null,
"raw_pages": "1118-22",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Janssen BJ",
"Robinson RA",
"Perez-Branguli F",
"Bell CH",
"Mitchell KJ",
"Siebold C",
"Jones EY."
],
"DOI_URL": "https://doi.org/10.1038/nature09468"
},
"PUB00074782": {
"PMID": 16672342,
"ISBN": null,
"volume": "133",
"issue": "11",
"year": 2006,
"title": "Drosophila Plexin B is a Sema-2a receptor required for axon guidance.",
"URL": null,
"raw_pages": "2125-35",
"medline_journal": "Development",
"ISO_journal": "Development",
"authors": [
"Ayoob JC",
"Terman JR",
"Kolodkin AL."
],
"DOI_URL": "http://dx.doi.org/10.1242/dev.02380"
},
"PUB00092465": {
"PMID": 17224402,
"ISBN": null,
"volume": "53",
"issue": "2",
"year": 2007,
"title": "Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactions.",
"URL": null,
"raw_pages": "185-200",
"medline_journal": "Neuron",
"ISO_journal": "Neuron",
"authors": [
"Sweeney LB",
"Couto A",
"Chou YH",
"Berdnik D",
"Dickson BJ",
"Luo L",
"Komiyama T."
],
"DOI_URL": "https://doi.org/10.1016/j.neuron.2006.12.022"
},
"PUB00092464": {
"PMID": 19052954,
"ISBN": null,
"volume": "23",
"issue": "1-2",
"year": 2009,
"title": "Genetic interaction of Neuroglian and Semaphorin1a during guidance and synapse formation.",
"URL": null,
"raw_pages": "147-55",
"medline_journal": "J Neurogenet",
"ISO_journal": "J. Neurogenet.",
"authors": [
"Godenschwege TA",
"Murphey RK."
],
"DOI_URL": "https://doi.org/10.1080/01677060802441380"
},
"PUB00091974": {
"PMID": 12700098,
"ISBN": null,
"volume": "8",
"issue": null,
"year": 2003,
"title": "The function of semaphorins during nervous system development.",
"URL": null,
"raw_pages": "s484-99",
"medline_journal": "Front Biosci",
"ISO_journal": "Front. Biosci.",
"authors": [
"Fiore R",
"Puschel AW."
],
"DOI_URL": "https://doi.org/10.2741/1080"
},
"PUB00043640": {
"PMID": 12110185,
"ISBN": null,
"volume": "109",
"issue": "7",
"year": 2002,
"title": "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.",
"URL": null,
"raw_pages": "887-900",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Terman JR",
"Mao T",
"Pasterkamp RJ",
"Yu HH",
"Kolodkin AL."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0092-8674(02)00794-8"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR015943",
"name": "WD40/YVTN repeat-like-containing domain superfamily",
"type": "homologous_superfamily"
},
{
"accession": "IPR036352",
"name": "Sema domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 616,
"pathways": 11,
"proteins": 616,
"proteomes": 232,
"sets": 0,
"structural_models": {
"alphafold": 522,
"bfvd": 0
},
"structures": 4,
"taxa": 1024
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
