"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"IPR042068"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 616, 'pathways': 11, 'proteins': 616, 'proteomes': 232, 'sets': 0, 'structural_models': {'alphafold': 522, 'bfvd': 0}, 'structures': 4, 'taxa': 1024}"	"{}"	"[{'text': '<p>This entry represents the Sema domain found in Sema1A, which is a transmembrane protein. Sema1A binds to its receptor plexin A (PlexA), which in turn triggers downstream signaling events involving the receptor tyrosine kinase Otk, the evolutionarily conserved flavoprotein monooxygenase molecule interacting with CasL (MICAL), and the A kinase anchoring protein Nervy, leading to repulsive growth-cone response [[cite:PUB00092465], [cite:PUB00074782], [cite:PUB00043640]]. Sema1A has also been shown to be involved in synaptic formation [[cite:PUB00092464]].</p>\r\n\r\n<p>Sema1A belongs to the semaphorin family, whose members are regulatory molecules in the development of the nervous system and in axonal guidance [[cite:PUB00091974]]. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer [[cite:PUB00063292]]. The Sema domain is located at the N terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module [[cite:PUB00091404]].</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	"[{'identifier': 'GO:0030215', 'name': 'semaphorin receptor binding', 'category': {'code': 'F', 'name': 'molecular_function'}}]"	"{'accession': 'IPR001627', 'name': 'Sema domain', 'type': 'Domain', 'children': [{'accession': 'IPR015513', 'name': 'Semaphorin 3E, Sema domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR039413', 'name': 'RON, Sema domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR041853', 'name': 'Plexin-C1, Sema domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042068', 'name': 'Semaphorin-1A, sema domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042582', 'name': 'Semaphorin-3D, Sema domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042719', 'name': 'Plexin-D1, sema domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042744', 'name': 'Plexin-A1, Sema domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042820', 'name': 'Semaphorin-3A, sema domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042821', 'name': 'Semaphorin-5A, sema domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042824', 'name': 'Semaphorin-7A, sema domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042826', 'name': 'Plexin-A2, sema domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR047085', 'name': 'Semaphorin 4F, Sema domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR048224', 'name': 'Semaphorin 5C, Sema domain', 'type': 'Domain', 'children': []}]}"	""	False	False	False	"{'PUB00063292': {'PMID': 16584533, 'ISBN': None, 'volume': '7', 'issue': '3', 'year': 2006, 'title': 'The semaphorins.', 'URL': None, 'raw_pages': '211', 'medline_journal': 'Genome Biol', 'ISO_journal': 'Genome Biol.', 'authors': ['Yazdani U', 'Terman JR.'], 'DOI_URL': 'http://dx.doi.org/10.1186/gb-2006-7-3-211'}, 'PUB00091404': {'PMID': 20877282, 'ISBN': None, 'volume': '467', 'issue': '7319', 'year': 2010, 'title': 'Structural basis of semaphorin-plexin signalling.', 'URL': None, 'raw_pages': '1118-22', 'medline_journal': 'Nature', 'ISO_journal': 'Nature', 'authors': ['Janssen BJ', 'Robinson RA', 'Perez-Branguli F', 'Bell CH', 'Mitchell KJ', 'Siebold C', 'Jones EY.'], 'DOI_URL': 'https://doi.org/10.1038/nature09468'}, 'PUB00074782': {'PMID': 16672342, 'ISBN': None, 'volume': '133', 'issue': '11', 'year': 2006, 'title': 'Drosophila Plexin B is a Sema-2a receptor required for axon guidance.', 'URL': None, 'raw_pages': '2125-35', 'medline_journal': 'Development', 'ISO_journal': 'Development', 'authors': ['Ayoob JC', 'Terman JR', 'Kolodkin AL.'], 'DOI_URL': 'http://dx.doi.org/10.1242/dev.02380'}, 'PUB00092465': {'PMID': 17224402, 'ISBN': None, 'volume': '53', 'issue': '2', 'year': 2007, 'title': 'Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactions.', 'URL': None, 'raw_pages': '185-200', 'medline_journal': 'Neuron', 'ISO_journal': 'Neuron', 'authors': ['Sweeney LB', 'Couto A', 'Chou YH', 'Berdnik D', 'Dickson BJ', 'Luo L', 'Komiyama T.'], 'DOI_URL': 'https://doi.org/10.1016/j.neuron.2006.12.022'}, 'PUB00092464': {'PMID': 19052954, 'ISBN': None, 'volume': '23', 'issue': '1-2', 'year': 2009, 'title': 'Genetic interaction of Neuroglian and Semaphorin1a during guidance and synapse formation.', 'URL': None, 'raw_pages': '147-55', 'medline_journal': 'J Neurogenet', 'ISO_journal': 'J. Neurogenet.', 'authors': ['Godenschwege TA', 'Murphey RK.'], 'DOI_URL': 'https://doi.org/10.1080/01677060802441380'}, 'PUB00091974': {'PMID': 12700098, 'ISBN': None, 'volume': '8', 'issue': None, 'year': 2003, 'title': 'The function of semaphorins during nervous system development.', 'URL': None, 'raw_pages': 's484-99', 'medline_journal': 'Front Biosci', 'ISO_journal': 'Front. Biosci.', 'authors': ['Fiore R', 'Puschel AW.'], 'DOI_URL': 'https://doi.org/10.2741/1080'}, 'PUB00043640': {'PMID': 12110185, 'ISBN': None, 'volume': '109', 'issue': '7', 'year': 2002, 'title': 'MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.', 'URL': None, 'raw_pages': '887-900', 'medline_journal': 'Cell', 'ISO_journal': 'Cell', 'authors': ['Terman JR', 'Mao T', 'Pasterkamp RJ', 'Yu HH', 'Kolodkin AL.'], 'DOI_URL': 'http://dx.doi.org/10.1016/S0092-8674(02)00794-8'}}"	"{'cdd': {'cd11237': 'The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A)'}}"	"{'name': 'Semaphorin-1A, sema domain', 'short': 'SEM1A_sema_dom'}"	"[{'accession': 'IPR015943', 'name': 'WD40/YVTN repeat-like-containing domain superfamily', 'type': 'homologous_superfamily'}, {'accession': 'IPR036352', 'name': 'Sema domain superfamily', 'type': 'homologous_superfamily'}]"	""	""	"interpro"	"domain"	""