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{
    "metadata": {
        "accession": "IPR029421",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "pfam": {
                "PF14918": "MDM2-binding"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR029421",
            "name": "MDM2-binding protein, N-terminal domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "MDM2-binding protein, N-terminal domain",
            "short": "MTBP_N"
        },
        "description": [
            {
                "text": "<p>This entry represents the N-terminal domain of the MDM2-binding protein (MTBP). MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53, leading to its degradation by the proteasome [[cite:PUB00068076]]. MTBP inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability, and this promotes MDM2-mediated ubiquitination of p53 and its subsequent degradation [[cite:PUB00068081]]. Mouse MTBP also inhibits cancer cell migration by interacting with alpha-actinin-4 (ACTN4) [[cite:PUB00070070]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00068076": {
                "PMID": 14707283,
                "ISBN": null,
                "volume": "1",
                "issue": "14",
                "year": 2003,
                "title": "The MDM2-p53 interaction.",
                "URL": null,
                "raw_pages": "1001-8",
                "medline_journal": "Mol Cancer Res",
                "ISO_journal": "Mol. Cancer Res.",
                "authors": [
                    "Moll UM",
                    "Petrenko O."
                ],
                "DOI_URL": null
            },
            "PUB00070070": {
                "PMID": 22370640,
                "ISBN": null,
                "volume": "32",
                "issue": "4",
                "year": 2013,
                "title": "MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4.",
                "URL": null,
                "raw_pages": "462-70",
                "medline_journal": "Oncogene",
                "ISO_journal": "Oncogene",
                "authors": [
                    "Agarwal N",
                    "Adhikari AS",
                    "Iyer SV",
                    "Hekmatdoost K",
                    "Welch DR",
                    "Iwakuma T."
                ],
                "DOI_URL": "http://dx.doi.org/10.1038/onc.2012.69"
            },
            "PUB00068081": {
                "PMID": 15632057,
                "ISBN": null,
                "volume": "25",
                "issue": "2",
                "year": 2005,
                "title": "Regulation of p53 and MDM2 activity by MTBP.",
                "URL": null,
                "raw_pages": "545-53",
                "medline_journal": "Mol Cell Biol",
                "ISO_journal": "Mol. Cell. Biol.",
                "authors": [
                    "Brady M",
                    "Vlatkovic N",
                    "Boyd MT."
                ],
                "DOI_URL": "http://dx.doi.org/10.1128/MCB.25.2.545-553.2005"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 18,
            "interactions": 0,
            "matches": 1002,
            "pathways": 2,
            "proteins": 988,
            "proteomes": 627,
            "sets": 0,
            "structural_models": {
                "alphafold": 900,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 2108
        },
        "entry_annotations": {
            "alignment:seed": 9,
            "alignment:full": 760
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}