"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"IPR029421"	"{'subfamilies': 0, 'domain_architectures': 18, 'interactions': 0, 'matches': 1002, 'pathways': 2, 'proteins': 988, 'proteomes': 627, 'sets': 0, 'structural_models': {'alphafold': 900, 'bfvd': 0}, 'structures': 0, 'taxa': 2108}"	"{}"	"[{'text': '<p>This entry represents the N-terminal domain of the MDM2-binding protein (MTBP). MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53, leading to its degradation by the proteasome [[cite:PUB00068076]]. MTBP inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability, and this promotes MDM2-mediated ubiquitination of p53 and its subsequent degradation [[cite:PUB00068081]]. Mouse MTBP also inhibits cancer cell migration by interacting with alpha-actinin-4 (ACTN4) [[cite:PUB00070070]].</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	"{'accession': 'IPR029421', 'name': 'MDM2-binding protein, N-terminal domain', 'type': 'Domain', 'children': []}"	""	False	False	False	"{'PUB00068076': {'PMID': 14707283, 'ISBN': None, 'volume': '1', 'issue': '14', 'year': 2003, 'title': 'The MDM2-p53 interaction.', 'URL': None, 'raw_pages': '1001-8', 'medline_journal': 'Mol Cancer Res', 'ISO_journal': 'Mol. Cancer Res.', 'authors': ['Moll UM', 'Petrenko O.'], 'DOI_URL': None}, 'PUB00070070': {'PMID': 22370640, 'ISBN': None, 'volume': '32', 'issue': '4', 'year': 2013, 'title': 'MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4.', 'URL': None, 'raw_pages': '462-70', 'medline_journal': 'Oncogene', 'ISO_journal': 'Oncogene', 'authors': ['Agarwal N', 'Adhikari AS', 'Iyer SV', 'Hekmatdoost K', 'Welch DR', 'Iwakuma T.'], 'DOI_URL': 'http://dx.doi.org/10.1038/onc.2012.69'}, 'PUB00068081': {'PMID': 15632057, 'ISBN': None, 'volume': '25', 'issue': '2', 'year': 2005, 'title': 'Regulation of p53 and MDM2 activity by MTBP.', 'URL': None, 'raw_pages': '545-53', 'medline_journal': 'Mol Cell Biol', 'ISO_journal': 'Mol. Cell. Biol.', 'authors': ['Brady M', 'Vlatkovic N', 'Boyd MT.'], 'DOI_URL': 'http://dx.doi.org/10.1128/MCB.25.2.545-553.2005'}}"	"{'pfam': {'PF14918': 'MDM2-binding'}}"	"{'name': 'MDM2-binding protein, N-terminal domain', 'short': 'MTBP_N'}"	""	""	""	"interpro"	"domain"	""