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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR026932",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0016540",
"name": "protein autoprocessing",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"pfam": {
"PF13887": "Myelin regulatory factor ICA domain"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR026932",
"name": "Myelin gene regulatory factor, ICA domain",
"type": "Domain",
"children": []
},
"name": {
"name": "Myelin gene regulatory factor, ICA domain",
"short": "MYRF_ICA"
},
"description": [
{
"text": "<p>Myelin regulatory factor (Myrf) is a transcription regulator required in vertebrates for expression of central nervous system (CNS) myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and CNS myelination [[cite:PUB00057918]]. It is also required for the maintenance of expression of myelin genes and the mature oligodendrocytes identity in the adult CNS [[cite:PUB00062316], [cite:PUB00095183]]. A Caenorhabditis elegans orthologue, pqn-47, may function as a regulator of molting [[cite:PUB00062040]], while a Dictyostelium orthologue has been described to regulate prestalk differentiation [[cite:PUB00062039]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>This domain is found towards the C terminus of myelin regulatory factor (Myrf) and corresponds to the Intramolecular Chaperone Auto-processing (ICA) domain. It forms a homo-trimer and carries out the auto-cleavage of Myrf releasing the N-terminal homo-trimer from the ER membrane. This allows its entry to the nucleus to function as a homo-trimer transcription factor [[cite:PUB00095183]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00062040": {
"PMID": 21989027,
"ISBN": null,
"volume": "360",
"issue": "2",
"year": 2011,
"title": "Regulation of the C. elegans molt by pqn-47.",
"URL": null,
"raw_pages": "297-309",
"medline_journal": "Dev Biol",
"ISO_journal": "Dev. Biol.",
"authors": [
"Russel S",
"Frand AR",
"Ruvkun G."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.ydbio.2011.09.025"
},
"PUB00062039": {
"PMID": 22811266,
"ISBN": null,
"volume": "56",
"issue": "5",
"year": 2012,
"title": "An orthologue of the Myelin-gene Regulatory Transcription Factor regulates Dictyostelium prestalk differentiation.",
"URL": null,
"raw_pages": "325-32",
"medline_journal": "Int J Dev Biol",
"ISO_journal": "Int. J. Dev. Biol.",
"authors": [
"Senoo H",
"Wang HY",
"Araki T",
"Williams JG",
"Fukuzawa M."
],
"DOI_URL": null
},
"PUB00062316": {
"PMID": 22956843,
"ISBN": null,
"volume": "32",
"issue": "36",
"year": 2012,
"title": "Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS.",
"URL": null,
"raw_pages": "12528-42",
"medline_journal": "J Neurosci",
"ISO_journal": "J. Neurosci.",
"authors": [
"Koenning M",
"Jackson S",
"Hay CM",
"Faux C",
"Kilpatrick TJ",
"Willingham M",
"Emery B."
],
"DOI_URL": "http://dx.doi.org/10.1523/JNEUROSCI.1069-12.2012"
},
"PUB00057918": {
"PMID": 19596243,
"ISBN": null,
"volume": "138",
"issue": "1",
"year": 2009,
"title": "Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination.",
"URL": null,
"raw_pages": "172-85",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Emery B",
"Agalliu D",
"Cahoy JD",
"Watkins TA",
"Dugas JC",
"Mulinyawe SB",
"Ibrahim A",
"Ligon KL",
"Rowitch DH",
"Barres BA."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.cell.2009.04.031"
},
"PUB00095183": {
"PMID": 31964908,
"ISBN": null,
"volume": "10",
"issue": "1",
"year": 2020,
"title": "Functional mechanism and pathogenic potential of MYRF ICA domain mutations implicated in birth defects.",
"URL": null,
"raw_pages": "814",
"medline_journal": "Sci Rep",
"ISO_journal": "Sci Rep",
"authors": [
"An H",
"Fan C",
"Sharif M",
"Kim D",
"Poitelon Y",
"Park Y."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 34,
"interactions": 0,
"matches": 2852,
"pathways": 0,
"proteins": 2846,
"proteomes": 1098,
"sets": 0,
"structural_models": {
"alphafold": 2349,
"bfvd": 0
},
"structures": 1,
"taxa": 3704
},
"entry_annotations": {
"alignment:seed": 8,
"alignment:full": 1897
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
