"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"IPR026932"	"{'subfamilies': 0, 'domain_architectures': 34, 'interactions': 0, 'matches': 2852, 'pathways': 0, 'proteins': 2846, 'proteomes': 1098, 'sets': 0, 'structural_models': {'alphafold': 2349, 'bfvd': 0}, 'structures': 1, 'taxa': 3704}"	"{}"	"[{'text': '<p>Myelin regulatory factor (Myrf) is a transcription regulator required in vertebrates for expression of central nervous system (CNS) myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and CNS myelination [[cite:PUB00057918]]. It is also required for the maintenance of expression of myelin genes and the mature oligodendrocytes identity in the adult CNS [[cite:PUB00062316], [cite:PUB00095183]]. A Caenorhabditis elegans orthologue, pqn-47, may function as a regulator of molting [[cite:PUB00062040]], while a Dictyostelium orthologue has been described to regulate prestalk differentiation [[cite:PUB00062039]].</p>', 'llm': False, 'checked': False, 'updated': False}, {'text': '<p>This domain is found towards the C terminus of myelin regulatory factor (Myrf) and corresponds to the Intramolecular Chaperone Auto-processing (ICA) domain. It forms a homo-trimer and carries out the auto-cleavage of Myrf releasing the N-terminal homo-trimer from the ER membrane. This allows its entry to the nucleus to function as a homo-trimer transcription factor [[cite:PUB00095183]].</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	"[{'identifier': 'GO:0016540', 'name': 'protein autoprocessing', 'category': {'code': 'P', 'name': 'biological_process'}}]"	"{'accession': 'IPR026932', 'name': 'Myelin gene regulatory factor, ICA domain', 'type': 'Domain', 'children': []}"	""	False	False	False	"{'PUB00062040': {'PMID': 21989027, 'ISBN': None, 'volume': '360', 'issue': '2', 'year': 2011, 'title': 'Regulation of the C. elegans molt by pqn-47.', 'URL': None, 'raw_pages': '297-309', 'medline_journal': 'Dev Biol', 'ISO_journal': 'Dev. Biol.', 'authors': ['Russel S', 'Frand AR', 'Ruvkun G.'], 'DOI_URL': 'http://dx.doi.org/10.1016/j.ydbio.2011.09.025'}, 'PUB00062039': {'PMID': 22811266, 'ISBN': None, 'volume': '56', 'issue': '5', 'year': 2012, 'title': 'An orthologue of the Myelin-gene Regulatory Transcription Factor regulates Dictyostelium prestalk differentiation.', 'URL': None, 'raw_pages': '325-32', 'medline_journal': 'Int J Dev Biol', 'ISO_journal': 'Int. J. Dev. Biol.', 'authors': ['Senoo H', 'Wang HY', 'Araki T', 'Williams JG', 'Fukuzawa M.'], 'DOI_URL': None}, 'PUB00062316': {'PMID': 22956843, 'ISBN': None, 'volume': '32', 'issue': '36', 'year': 2012, 'title': 'Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS.', 'URL': None, 'raw_pages': '12528-42', 'medline_journal': 'J Neurosci', 'ISO_journal': 'J. Neurosci.', 'authors': ['Koenning M', 'Jackson S', 'Hay CM', 'Faux C', 'Kilpatrick TJ', 'Willingham M', 'Emery B.'], 'DOI_URL': 'http://dx.doi.org/10.1523/JNEUROSCI.1069-12.2012'}, 'PUB00057918': {'PMID': 19596243, 'ISBN': None, 'volume': '138', 'issue': '1', 'year': 2009, 'title': 'Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination.', 'URL': None, 'raw_pages': '172-85', 'medline_journal': 'Cell', 'ISO_journal': 'Cell', 'authors': ['Emery B', 'Agalliu D', 'Cahoy JD', 'Watkins TA', 'Dugas JC', 'Mulinyawe SB', 'Ibrahim A', 'Ligon KL', 'Rowitch DH', 'Barres BA.'], 'DOI_URL': 'http://dx.doi.org/10.1016/j.cell.2009.04.031'}, 'PUB00095183': {'PMID': 31964908, 'ISBN': None, 'volume': '10', 'issue': '1', 'year': 2020, 'title': 'Functional mechanism and pathogenic potential of MYRF ICA domain mutations implicated in birth defects.', 'URL': None, 'raw_pages': '814', 'medline_journal': 'Sci Rep', 'ISO_journal': 'Sci Rep', 'authors': ['An H', 'Fan C', 'Sharif M', 'Kim D', 'Poitelon Y', 'Park Y.'], 'DOI_URL': None}}"	"{'pfam': {'PF13887': 'Myelin regulatory factor ICA domain'}}"	"{'name': 'Myelin gene regulatory factor, ICA domain', 'short': 'MYRF_ICA'}"	""	""	""	"interpro"	"domain"	""