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{
    "metadata": {
        "accession": "IPR019588",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "smart": {
                "SM01229": "GluR_Homer-bdg"
            },
            "pfam": {
                "PF10606": "Homer-binding domain of metabotropic glutamate receptor"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR019588",
            "name": "Metabotropic glutamate receptor, Homer-binding domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Metabotropic glutamate receptor, Homer-binding domain",
            "short": "Metabotropic_Glu_rcpt_Homer-bd"
        },
        "description": [
            {
                "text": "<p>This entry represents the proline-rich region of metabotropic glutamate receptor proteins that bind Homer-related synaptic proteins.</p>\n\n<p>Metabotropic glutamate receptors function as receptors for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.</p>\n\n<p>The Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R) that appears to be due to the proline-rich Homer ligand (PPXXFr). Activation of PI turnover triggers intracellular calcium release [[cite:PUB00044281]]. Metabotropic glutamate receptor (MGluR) function is altered in the mouse model of human Fragile X syndrome, a disorder caused by loss of function mutations in the Fragile X messenger ribonucleoprotein 1 gene Fmr1. Homer 3 (and to a lesser extent Homer 1b/c) has been shown to form a multimeric complex with mGlu1a and the IP3 receptor, indicating that Homers may play a role in the localisation of receptors to their signalling partners [[cite:PUB00044282]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00044281": {
                "PMID": 9808459,
                "ISBN": null,
                "volume": "21",
                "issue": "4",
                "year": 1998,
                "title": "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.",
                "URL": null,
                "raw_pages": "717-26",
                "medline_journal": "Neuron",
                "ISO_journal": "Neuron",
                "authors": [
                    "Tu JC",
                    "Xiao B",
                    "Yuan JP",
                    "Lanahan AA",
                    "Leoffert K",
                    "Li M",
                    "Linden DJ",
                    "Worley PF."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/S0896-6273(00)80589-9"
            },
            "PUB00044282": {
                "PMID": 18184796,
                "ISBN": null,
                "volume": "28",
                "issue": "2",
                "year": 2008,
                "title": "Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation.",
                "URL": null,
                "raw_pages": "543-7",
                "medline_journal": "J Neurosci",
                "ISO_journal": "J. Neurosci.",
                "authors": [
                    "Ronesi JA",
                    "Huber KM."
                ],
                "DOI_URL": "http://dx.doi.org/10.1523/JNEUROSCI.5019-07.2008"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 14,
            "interactions": 0,
            "matches": 2572,
            "pathways": 10,
            "proteins": 2572,
            "proteomes": 696,
            "sets": 0,
            "structural_models": {
                "alphafold": 2356,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 2151
        },
        "entry_annotations": {
            "alignment:seed": 12,
            "alignment:full": 1946
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}