"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"IPR019588"	"{'subfamilies': 0, 'domain_architectures': 14, 'interactions': 0, 'matches': 2572, 'pathways': 10, 'proteins': 2572, 'proteomes': 696, 'sets': 0, 'structural_models': {'alphafold': 2356, 'bfvd': 0}, 'structures': 0, 'taxa': 2151}"	"{}"	"[{'text': '<p>This entry represents the proline-rich region of metabotropic glutamate receptor proteins that bind Homer-related synaptic proteins.</p>\n\n<p>Metabotropic glutamate receptors function as receptors for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.</p>\n\n<p>The Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R) that appears to be due to the proline-rich Homer ligand (PPXXFr). Activation of PI turnover triggers intracellular calcium release [[cite:PUB00044281]]. Metabotropic glutamate receptor (MGluR) function is altered in the mouse model of human Fragile X syndrome, a disorder caused by loss of function mutations in the Fragile X messenger ribonucleoprotein 1 gene Fmr1. Homer 3 (and to a lesser extent Homer 1b/c) has been shown to form a multimeric complex with mGlu1a and the IP3 receptor, indicating that Homers may play a role in the localisation of receptors to their signalling partners [[cite:PUB00044282]].</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	"{'accession': 'IPR019588', 'name': 'Metabotropic glutamate receptor, Homer-binding domain', 'type': 'Domain', 'children': []}"	""	False	False	False	"{'PUB00044281': {'PMID': 9808459, 'ISBN': None, 'volume': '21', 'issue': '4', 'year': 1998, 'title': 'Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.', 'URL': None, 'raw_pages': '717-26', 'medline_journal': 'Neuron', 'ISO_journal': 'Neuron', 'authors': ['Tu JC', 'Xiao B', 'Yuan JP', 'Lanahan AA', 'Leoffert K', 'Li M', 'Linden DJ', 'Worley PF.'], 'DOI_URL': 'http://dx.doi.org/10.1016/S0896-6273(00)80589-9'}, 'PUB00044282': {'PMID': 18184796, 'ISBN': None, 'volume': '28', 'issue': '2', 'year': 2008, 'title': 'Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation.', 'URL': None, 'raw_pages': '543-7', 'medline_journal': 'J Neurosci', 'ISO_journal': 'J. Neurosci.', 'authors': ['Ronesi JA', 'Huber KM.'], 'DOI_URL': 'http://dx.doi.org/10.1523/JNEUROSCI.5019-07.2008'}}"	"{'smart': {'SM01229': 'GluR_Homer-bdg'}, 'pfam': {'PF10606': 'Homer-binding domain of metabotropic glutamate receptor'}}"	"{'name': 'Metabotropic glutamate receptor, Homer-binding domain', 'short': 'Metabotropic_Glu_rcpt_Homer-bd'}"	""	""	""	"interpro"	"domain"	""