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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR007528",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0006890",
"name": "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0070939",
"name": "Dsl1/NZR complex",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"profile": {
"PS51386": "RINT1/TIP20 domain profile"
},
"pfam": {
"PF04437": "RINT-1/TIP-1 family"
},
"panther": {
"PTHR13520": "RAD50-INTERACTING PROTEIN 1 RINT-1"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR007528",
"name": "RINT-1/Tip20",
"type": "Family",
"children": []
},
"name": {
"name": "RINT-1/Tip20",
"short": "RINT1_Tip20"
},
"description": [
{
"text": "<p>This entry includes RINT-1 from animals, Tip20 from yeasts and MAIGO2 (Mag2) from plants. They play a role in anterograde transport from the endoplasmic reticulum (ER) to the Golgi and/or retrograde transport from the Golgi to the ER share sequence similarity [[cite:PUB00100047]]. They are part of the CATCHR (complexes associated with tethering containing helical rods) family which comprises the exocyst, COG, GARP, and DSL1 complexes and share a similar structure organisation with an N-terminal coiled-coil and a C-terminal α-helical bundle, which might be a protein-protein interaction module necessary for the formation of functional complexes.</p>\n\n<p>RINT-1 interacts with Rad50 only during late S and G2/M phases and participates in radiation induced checkpoint control [[cite:PUB00010117]]. RINT-1 also functions in membrane trafficking from the endoplasmic reticulum (ER) to the Golgi complex in interphase cells [[cite:PUB00010117], [cite:PUB00043787], [cite:PUB00043788]].</p>\n\n<p>Tip20 is involved in the retrograde transport from the Golgi to the ER [[cite:PUB00051798], [cite:PUB00010001]].</p>\n\n<p>Arabidopsis Mag2 functions in the transport of storage protein precursors between the ER and Golgi complex in plants [[cite:PUB00072705], [cite:PUB00072936]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00010001": {
"PMID": 8334998,
"ISBN": null,
"volume": "12",
"issue": "7",
"year": 1993,
"title": "The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p.",
"URL": null,
"raw_pages": "2831-40",
"medline_journal": "EMBO J",
"ISO_journal": "EMBO J.",
"authors": [
"Sweet DJ",
"Pelham HR."
],
"DOI_URL": "http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=8334998&action=stream&blobtype=pdf"
},
"PUB00010117": {
"PMID": 11096100,
"ISBN": null,
"volume": "276",
"issue": "9",
"year": 2001,
"title": "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control.",
"URL": null,
"raw_pages": "6105-11",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Xiao J",
"Liu CC",
"Chen PL",
"Lee WH."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M008893200"
},
"PUB00072705": {
"PMID": 17194767,
"ISBN": null,
"volume": "18",
"issue": "12",
"year": 2006,
"title": "MAIGO2 is involved in exit of seed storage proteins from the endoplasmic reticulum in Arabidopsis thaliana.",
"URL": null,
"raw_pages": "3535-47",
"medline_journal": "Plant Cell",
"ISO_journal": "Plant Cell",
"authors": [
"Li L",
"Shimada T",
"Takahashi H",
"Ueda H",
"Fukao Y",
"Kondo M",
"Nishimura M",
"Hara-Nishimura I."
],
"DOI_URL": "http://dx.doi.org/10.1105/tpc.106.046151"
},
"PUB00051798": {
"PMID": 19151722,
"ISBN": null,
"volume": "16",
"issue": "2",
"year": 2009,
"title": "Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex.",
"URL": null,
"raw_pages": "114-23",
"medline_journal": "Nat Struct Mol Biol",
"ISO_journal": "Nat. Struct. Mol. Biol.",
"authors": [
"Tripathi A",
"Ren Y",
"Jeffrey PD",
"Hughson FM."
],
"DOI_URL": "http://dx.doi.org/10.1038/nsmb.1548"
},
"PUB00043787": {
"PMID": 16600870,
"ISBN": null,
"volume": "22",
"issue": "1",
"year": 2006,
"title": "The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1.",
"URL": null,
"raw_pages": "63-71",
"medline_journal": "Mol Cell",
"ISO_journal": "Mol. Cell",
"authors": [
"Kong LJ",
"Meloni AR",
"Nevins JR."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.molcel.2006.02.016"
},
"PUB00043788": {
"PMID": 16571679,
"ISBN": null,
"volume": "17",
"issue": "6",
"year": 2006,
"title": "RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex.",
"URL": null,
"raw_pages": "2780-8",
"medline_journal": "Mol Biol Cell",
"ISO_journal": "Mol. Biol. Cell",
"authors": [
"Arasaki K",
"Taniguchi M",
"Tani K",
"Tagaya M."
],
"DOI_URL": "http://dx.doi.org/10.1091/mbc.E05-10-0973"
},
"PUB00100047": {
"PMID": 34061181,
"ISBN": null,
"volume": "13",
"issue": "7",
"year": 2021,
"title": "Homology and Modular Evolution of CATCHR at the Origin of the Eukaryotic Endomembrane System.",
"URL": null,
"raw_pages": null,
"medline_journal": "Genome Biol Evol",
"ISO_journal": "Genome Biol Evol",
"authors": [
"Santana-Molina C",
"Gutierrez F",
"Devos DP."
],
"DOI_URL": null
},
"PUB00072936": {
"PMID": 24118572,
"ISBN": null,
"volume": "76",
"issue": "5",
"year": 2013,
"title": "MAG2 and three MAG2-INTERACTING PROTEINs form an ER-localized complex to facilitate storage protein transport in Arabidopsis thaliana.",
"URL": null,
"raw_pages": "781-91",
"medline_journal": "Plant J",
"ISO_journal": "Plant J.",
"authors": [
"Li L",
"Shimada T",
"Takahashi H",
"Koumoto Y",
"Shirakawa M",
"Takagi J",
"Zhao X",
"Tu B",
"Jin H",
"Shen Z",
"Han B",
"Jia M",
"Kondo M",
"Nishimura M",
"Hara-Nishimura I."
],
"DOI_URL": "http://dx.doi.org/10.1111/tpj.12347"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR042042",
"name": "Protein transport protein Tip20, domain B",
"type": "homologous_superfamily"
},
{
"accession": "IPR042041",
"name": "Protein transport protein Tip20, domain A",
"type": "homologous_superfamily"
},
{
"accession": "IPR042043",
"name": "Protein transport protein Tip20, domain C",
"type": "homologous_superfamily"
},
{
"accession": "IPR042040",
"name": "Protein transport protein Tip20, domain E",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 73,
"interactions": 0,
"matches": 5265,
"pathways": 5,
"proteins": 5226,
"proteomes": 3117,
"sets": 0,
"structural_models": {
"alphafold": 4623,
"bfvd": 0
},
"structures": 3,
"taxa": 8743
},
"entry_annotations": {
"alignment:seed": 55,
"alignment:full": 3403
},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
