{"metadata":{"accession":"IPR007528","entry_id":null,"type":"family","go_terms":[{"identifier":"GO:0006890","name":"retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0070939","name":"Dsl1/NZR complex","category":{"code":"C","name":"cellular_component"}}],"source_database":"interpro","member_databases":{"profile":{"PS51386":"RINT1/TIP20 domain profile"},"pfam":{"PF04437":"RINT-1/TIP-1 family"},"panther":{"PTHR13520":"RAD50-INTERACTING PROTEIN 1 RINT-1"}},"integrated":null,"hierarchy":{"accession":"IPR007528","name":"RINT-1/Tip20","type":"Family","children":[]},"name":{"name":"RINT-1/Tip20","short":"RINT1_Tip20"},"description":[{"text":"<p>This entry includes RINT-1 from animals, Tip20 from yeasts and MAIGO2 (Mag2) from plants. They play a role in anterograde transport from the endoplasmic reticulum (ER) to the Golgi and/or retrograde transport from the Golgi to the ER share sequence similarity [[cite:PUB00100047]]. They are part of the CATCHR (complexes associated with tethering containing helical rods) family which comprises the exocyst, COG, GARP, and DSL1 complexes and share a similar structure organisation with an N-terminal coiled-coil and a C-terminal α-helical bundle, which might be a protein-protein interaction module necessary for the formation of functional complexes.</p>\n\n<p>RINT-1 interacts with Rad50 only during late S  and  G2/M phases and participates in radiation induced checkpoint control [[cite:PUB00010117]]. RINT-1 also functions in membrane trafficking from the endoplasmic reticulum (ER) to the Golgi complex in interphase cells [[cite:PUB00010117], [cite:PUB00043787], [cite:PUB00043788]].</p>\n\n<p>Tip20 is involved in the retrograde transport from the Golgi to the ER [[cite:PUB00051798], [cite:PUB00010001]].</p>\n\n<p>Arabidopsis Mag2 functions in the transport of storage protein precursors between the ER and Golgi complex in plants [[cite:PUB00072705], [cite:PUB00072936]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00010001":{"PMID":8334998,"ISBN":null,"volume":"12","issue":"7","year":1993,"title":"The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p.","URL":null,"raw_pages":"2831-40","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Sweet DJ","Pelham HR."],"DOI_URL":"http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=8334998&action=stream&blobtype=pdf"},"PUB00010117":{"PMID":11096100,"ISBN":null,"volume":"276","issue":"9","year":2001,"title":"RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control.","URL":null,"raw_pages":"6105-11","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Xiao J","Liu CC","Chen PL","Lee WH."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M008893200"},"PUB00072705":{"PMID":17194767,"ISBN":null,"volume":"18","issue":"12","year":2006,"title":"MAIGO2 is involved in exit of seed storage proteins from the endoplasmic reticulum in Arabidopsis thaliana.","URL":null,"raw_pages":"3535-47","medline_journal":"Plant Cell","ISO_journal":"Plant Cell","authors":["Li L","Shimada T","Takahashi H","Ueda H","Fukao Y","Kondo M","Nishimura M","Hara-Nishimura I."],"DOI_URL":"http://dx.doi.org/10.1105/tpc.106.046151"},"PUB00051798":{"PMID":19151722,"ISBN":null,"volume":"16","issue":"2","year":2009,"title":"Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex.","URL":null,"raw_pages":"114-23","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Tripathi A","Ren Y","Jeffrey PD","Hughson FM."],"DOI_URL":"http://dx.doi.org/10.1038/nsmb.1548"},"PUB00043787":{"PMID":16600870,"ISBN":null,"volume":"22","issue":"1","year":2006,"title":"The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1.","URL":null,"raw_pages":"63-71","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Kong LJ","Meloni AR","Nevins JR."],"DOI_URL":"http://dx.doi.org/10.1016/j.molcel.2006.02.016"},"PUB00043788":{"PMID":16571679,"ISBN":null,"volume":"17","issue":"6","year":2006,"title":"RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex.","URL":null,"raw_pages":"2780-8","medline_journal":"Mol Biol Cell","ISO_journal":"Mol. Biol. Cell","authors":["Arasaki K","Taniguchi M","Tani K","Tagaya M."],"DOI_URL":"http://dx.doi.org/10.1091/mbc.E05-10-0973"},"PUB00100047":{"PMID":34061181,"ISBN":null,"volume":"13","issue":"7","year":2021,"title":"Homology and Modular Evolution of CATCHR at the Origin of the Eukaryotic Endomembrane System.","URL":null,"raw_pages":null,"medline_journal":"Genome Biol Evol","ISO_journal":"Genome Biol Evol","authors":["Santana-Molina C","Gutierrez F","Devos DP."],"DOI_URL":null},"PUB00072936":{"PMID":24118572,"ISBN":null,"volume":"76","issue":"5","year":2013,"title":"MAG2 and three MAG2-INTERACTING PROTEINs form an ER-localized complex to facilitate storage protein transport in Arabidopsis thaliana.","URL":null,"raw_pages":"781-91","medline_journal":"Plant J","ISO_journal":"Plant J.","authors":["Li L","Shimada T","Takahashi H","Koumoto Y","Shirakawa M","Takagi J","Zhao X","Tu B","Jin H","Shen Z","Han B","Jia M","Kondo M","Nishimura M","Hara-Nishimura I."],"DOI_URL":"http://dx.doi.org/10.1111/tpj.12347"}},"set_info":null,"overlaps_with":[{"accession":"IPR042042","name":"Protein transport protein Tip20, domain B","type":"homologous_superfamily"},{"accession":"IPR042041","name":"Protein transport protein Tip20, domain A","type":"homologous_superfamily"},{"accession":"IPR042043","name":"Protein transport protein Tip20, domain C","type":"homologous_superfamily"},{"accession":"IPR042040","name":"Protein transport protein Tip20, domain E","type":"homologous_superfamily"}],"counters":{"subfamilies":0,"domain_architectures":73,"interactions":0,"matches":5265,"pathways":5,"proteins":5226,"proteomes":3117,"sets":0,"structural_models":{"alphafold":4623,"bfvd":0},"structures":3,"taxa":8743},"entry_annotations":{"alignment:seed":55,"alignment:full":3403},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}