HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept
{
"metadata": {
"accession": "IPR004584",
"entry_id": null,
"type": "family",
"go_terms": [
{
"identifier": "GO:0016887",
"name": "ATP hydrolysis activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0000723",
"name": "telomere maintenance",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0006281",
"name": "DNA repair",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0005634",
"name": "nucleus",
"category": {
"code": "C",
"name": "cellular_component"
}
},
{
"identifier": "GO:0030870",
"name": "Mre11 complex",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"source_database": "interpro",
"member_databases": {
"ncbifam": {
"TIGR00606": "DNA repair protein Rad50"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR004584",
"name": "DNA repair protein Rad50, eukaryotes",
"type": "Family",
"children": []
},
"name": {
"name": "DNA repair protein Rad50, eukaryotes",
"short": "Rad50_eukaryotes"
},
"description": [
{
"text": "<p>RAD50 is involved in DNA double-strand break repair (DSBR), telomere maintenance and meiotic recombination [[cite:PUB00062772], [cite:PUB00072599], [cite:PUB00072600]]. The RAD50/MRE11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific exonuclease activity [[cite:PUB00062773], [cite:PUB00062774]]. RAD50 provides ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the MRE11 active site [[cite:PUB00062775], [cite:PUB00062776], [cite:PUB00062777]]. This entry represents the eukaryotic Rad50 that is distantly related to the SbcC family of bacterial proteins.</p>\r\n\r\n<p>In Saccharomyces cerevisiae, Rad50 forms the MRX complex with Mre11 and Xrs2.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00062777": {
"PMID": 17698079,
"ISBN": null,
"volume": "372",
"issue": "4",
"year": 2007,
"title": "The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity.",
"URL": null,
"raw_pages": "864-82",
"medline_journal": "J Mol Biol",
"ISO_journal": "J. Mol. Biol.",
"authors": [
"Ghosal G",
"Muniyappa K."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.jmb.2007.07.013"
},
"PUB00062772": {
"PMID": 9590181,
"ISBN": null,
"volume": "93",
"issue": "3",
"year": 1998,
"title": "The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.",
"URL": null,
"raw_pages": "477-86",
"medline_journal": "Cell",
"ISO_journal": "Cell",
"authors": [
"Carney JP",
"Maser RS",
"Olivares H",
"Davis EM",
"Le Beau M",
"Yates JR 3rd",
"Hays L",
"Morgan WF",
"Petrini JH."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0092-8674(00)81175-7"
},
"PUB00062775": {
"PMID": 9705271,
"ISBN": null,
"volume": "273",
"issue": "34",
"year": 1998,
"title": "Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.",
"URL": null,
"raw_pages": "21447-50",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Trujillo KM",
"Yuan SS",
"Lee EY",
"Sung P."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.273.34.21447"
},
"PUB00062776": {
"PMID": 11454871,
"ISBN": null,
"volume": "276",
"issue": "38",
"year": 2001,
"title": "DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex.",
"URL": null,
"raw_pages": "35458-64",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Trujillo KM",
"Sung P."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M105482200"
},
"PUB00062773": {
"PMID": 15296753,
"ISBN": null,
"volume": "14",
"issue": "15",
"year": 2004,
"title": "The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage.",
"URL": null,
"raw_pages": "1360-6",
"medline_journal": "Curr Biol",
"ISO_journal": "Curr. Biol.",
"authors": [
"Ciapponi L",
"Cenci G",
"Ducau J",
"Flores C",
"Johnson-Schlitz D",
"Gorski MM",
"Engels WR",
"Gatti M."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.cub.2004.07.019"
},
"PUB00062774": {
"PMID": 15135728,
"ISBN": null,
"volume": "3",
"issue": "6",
"year": 2004,
"title": "Disruption of Drosophila Rad50 causes pupal lethality, the accumulation of DNA double-strand breaks and the induction of apoptosis in third instar larvae.",
"URL": null,
"raw_pages": "603-15",
"medline_journal": "DNA Repair (Amst)",
"ISO_journal": "DNA Repair (Amst.)",
"authors": [
"Gorski MM",
"Romeijn RJ",
"Eeken JC",
"de Jong AW",
"van Veen BL",
"Szuhai K",
"Mullenders LH",
"Ferro W",
"Pastink A."
],
"DOI_URL": null
},
"PUB00072599": {
"PMID": 24168161,
"ISBN": null,
"volume": "90",
"issue": "1",
"year": 2014,
"title": "Radiation-induced telomere length variations in normal and in Nijmegen Breakage Syndrome cells.",
"URL": null,
"raw_pages": "45-52",
"medline_journal": "Int J Radiat Biol",
"ISO_journal": "Int. J. Radiat. Biol.",
"authors": [
"Berardinelli F",
"Sgura A",
"Di Masi A",
"Leone S",
"Cirrone GA",
"Romano F",
"Tanzarella C",
"Antoccia A."
],
"DOI_URL": "http://dx.doi.org/10.3109/09553002.2014.859400"
},
"PUB00072593": {
"PMID": 19409520,
"ISBN": null,
"volume": "84",
"issue": "5",
"year": 2009,
"title": "Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.",
"URL": null,
"raw_pages": "605-16",
"medline_journal": "Am J Hum Genet",
"ISO_journal": "Am. J. Hum. Genet.",
"authors": [
"Waltes R",
"Kalb R",
"Gatei M",
"Kijas AW",
"Stumm M",
"Sobeck A",
"Wieland B",
"Varon R",
"Lerenthal Y",
"Lavin MF",
"Schindler D",
"Dork T."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.ajhg.2009.04.010"
},
"PUB00072600": {
"PMID": 23671188,
"ISBN": null,
"volume": "33",
"issue": "14",
"year": 2013,
"title": "Impaired resection of meiotic double-strand breaks channels repair to nonhomologous end joining in Caenorhabditis elegans.",
"URL": null,
"raw_pages": "2732-47",
"medline_journal": "Mol Cell Biol",
"ISO_journal": "Mol. Cell. Biol.",
"authors": [
"Yin Y",
"Smolikove S."
],
"DOI_URL": "http://dx.doi.org/10.1128/MCB.00055-13"
},
"PUB00072747": {
"PMID": 21734400,
"ISBN": null,
"volume": "71",
"issue": "2",
"year": 2011,
"title": "Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma.",
"URL": null,
"raw_pages": "97-105",
"medline_journal": "Hum Hered",
"ISO_journal": "Hum. Hered.",
"authors": [
"Murk W",
"Walsh K",
"Hsu LI",
"Zhao L",
"Bracken MB",
"Dewan AT."
],
"DOI_URL": "http://dx.doi.org/10.1159/000319536"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR027417",
"name": "P-loop containing nucleoside triphosphate hydrolase",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 3910,
"pathways": 64,
"proteins": 3789,
"proteomes": 2431,
"sets": 0,
"structural_models": {
"alphafold": 738,
"bfvd": 0
},
"structures": 8,
"taxa": 7062
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
