RAD50 is involved in DNA double-strand break repair (DSBR), telomere maintenance and meiotic recombination [[cite:PUB00062772], [cite:PUB00072599], [cite:PUB00072600]]. The RAD50/MRE11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific exonuclease activity [[cite:PUB00062773], [cite:PUB00062774]]. RAD50 provides ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the MRE11 active site [[cite:PUB00062775], [cite:PUB00062776], [cite:PUB00062777]]. This entry represents the eukaryotic Rad50 that is distantly related to the SbcC family of bacterial proteins.
\r\n\r\nIn Saccharomyces cerevisiae, Rad50 forms the MRX complex with Mre11 and Xrs2.
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Biol.","authors":["Ghosal G","Muniyappa K."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2007.07.013"},"PUB00062772":{"PMID":9590181,"ISBN":null,"volume":"93","issue":"3","year":1998,"title":"The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.","URL":null,"raw_pages":"477-86","medline_journal":"Cell","ISO_journal":"Cell","authors":["Carney JP","Maser RS","Olivares H","Davis EM","Le Beau M","Yates JR 3rd","Hays L","Morgan WF","Petrini JH."],"DOI_URL":"http://dx.doi.org/10.1016/S0092-8674(00)81175-7"},"PUB00062775":{"PMID":9705271,"ISBN":null,"volume":"273","issue":"34","year":1998,"title":"Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.","URL":null,"raw_pages":"21447-50","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Trujillo KM","Yuan SS","Lee EY","Sung P."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.273.34.21447"},"PUB00062776":{"PMID":11454871,"ISBN":null,"volume":"276","issue":"38","year":2001,"title":"DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex.","URL":null,"raw_pages":"35458-64","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Trujillo KM","Sung P."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M105482200"},"PUB00062773":{"PMID":15296753,"ISBN":null,"volume":"14","issue":"15","year":2004,"title":"The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage.","URL":null,"raw_pages":"1360-6","medline_journal":"Curr Biol","ISO_journal":"Curr. Biol.","authors":["Ciapponi L","Cenci G","Ducau J","Flores C","Johnson-Schlitz D","Gorski MM","Engels WR","Gatti M."],"DOI_URL":"http://dx.doi.org/10.1016/j.cub.2004.07.019"},"PUB00062774":{"PMID":15135728,"ISBN":null,"volume":"3","issue":"6","year":2004,"title":"Disruption of Drosophila Rad50 causes pupal lethality, the accumulation of DNA double-strand breaks and the induction of apoptosis in third instar larvae.","URL":null,"raw_pages":"603-15","medline_journal":"DNA Repair (Amst)","ISO_journal":"DNA Repair (Amst.)","authors":["Gorski MM","Romeijn RJ","Eeken JC","de Jong AW","van Veen BL","Szuhai K","Mullenders LH","Ferro W","Pastink A."],"DOI_URL":null},"PUB00072599":{"PMID":24168161,"ISBN":null,"volume":"90","issue":"1","year":2014,"title":"Radiation-induced telomere length variations in normal and in Nijmegen Breakage Syndrome cells.","URL":null,"raw_pages":"45-52","medline_journal":"Int J Radiat Biol","ISO_journal":"Int. J. Radiat. Biol.","authors":["Berardinelli F","Sgura A","Di Masi A","Leone S","Cirrone GA","Romano F","Tanzarella C","Antoccia A."],"DOI_URL":"http://dx.doi.org/10.3109/09553002.2014.859400"},"PUB00072593":{"PMID":19409520,"ISBN":null,"volume":"84","issue":"5","year":2009,"title":"Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.","URL":null,"raw_pages":"605-16","medline_journal":"Am J Hum Genet","ISO_journal":"Am. J. Hum. Genet.","authors":["Waltes R","Kalb R","Gatei M","Kijas AW","Stumm M","Sobeck A","Wieland B","Varon R","Lerenthal Y","Lavin MF","Schindler D","Dork T."],"DOI_URL":"http://dx.doi.org/10.1016/j.ajhg.2009.04.010"},"PUB00072600":{"PMID":23671188,"ISBN":null,"volume":"33","issue":"14","year":2013,"title":"Impaired resection of meiotic double-strand breaks channels repair to nonhomologous end joining in Caenorhabditis elegans.","URL":null,"raw_pages":"2732-47","medline_journal":"Mol Cell Biol","ISO_journal":"Mol. Cell. Biol.","authors":["Yin Y","Smolikove S."],"DOI_URL":"http://dx.doi.org/10.1128/MCB.00055-13"},"PUB00072747":{"PMID":21734400,"ISBN":null,"volume":"71","issue":"2","year":2011,"title":"Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma.","URL":null,"raw_pages":"97-105","medline_journal":"Hum Hered","ISO_journal":"Hum. Hered.","authors":["Murk W","Walsh K","Hsu LI","Zhao L","Bracken MB","Dewan AT."],"DOI_URL":"http://dx.doi.org/10.1159/000319536"}},"set_info":null,"overlaps_with":[{"accession":"IPR027417","name":"P-loop containing nucleoside triphosphate hydrolase","type":"homologous_superfamily"}],"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":3910,"pathways":64,"proteins":3789,"proteomes":2431,"sets":0,"structural_models":{"alphafold":738,"bfvd":0},"structures":8,"taxa":7062},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}