Exploring gene expression results across species under different biological conditions
Expression Atlas is an open science resource that gives users a powerful way to find information about gene
and protein expression across species and biological conditions such as different tissues, cell types,
developmental stages and diseases among others. Expression Atlas aims to help answering questions such as
‘where is a certain gene expressed?’ or ‘how does its expression change in a disease?’.
Expression Atlas provides gene expression results on more than 3,000 experiments (microarray and
RNA-sequencing) from 40 different organisms, including metazoans and plants. Expression profiles of
tissues from Human Protein Atlas, GTEx and FANTOM5, and of cancer cell lines from ENCODE, CCLE and
Genentech projects can be explored in Expression Atlas. All data are manually curated, annotated to
ontology terms allowing for much richer queries and re-analysed using standardised methods.
Expression Atlas visualises gene expression results using heatmaps showing gene expression levels
across different biological conditions. Novel analyses and visualisations include: ‘enrichment’ in each
differential comparison of GO terms, Reactome, Plant Reactome pathways and InterPro domains;
hierarchical clustering (by baseline expression) of most variable genes and experimental conditions;
and, for a given gene-condition, distribution of baseline expression across biological replicates.