Gene summary: sequence, alignment information, cellular phenotypes observed

Gene summary: MYO9B

Gene information:

Synonyms:: CELIAC4

Gene description:: myosin IXB [Source:HGNC Symbol;Acc:HGNC:7609]

Ensembl ID:: ENSG00000099331

Protein domains: (provided by InterPro)

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Gene Ontology:

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Gene Ontology:

ENST00000595618,
ENST00000598419,
ENST00000597073,
ENST00000594824,
ENST00000602177,
ENST00000595641:

GTPase activator activity

ENST00000397274,
ENST00000595618,
ENST00000598419,
ENST00000597073,
ENST00000594824,
ENST00000602177,
ENST00000595641:

intracellular signal transduction

ENST00000596942,
ENST00000397274,
ENST00000595618,
ENST00000597073,
ENST00000594824,
ENST00000595641:

intracellular; signal transduction

ENST00000397274,
ENST00000595618,
ENST00000594971,
ENST00000594824,
ENST00000602177,
ENST00000595641:

ATP binding; myosin complex

ENST00000595618:

ATP catabolic process; ATP-dependent protein binding; actin filament; actin filament binding; actin-dependent ATPase activity; establishment of cell polarity; filopodium tip; lamellipodium; lamellipodium morphogenesis; macrophage chemotaxis; monocyte chemotaxis; positive regulation of Rho GTPase activity; ruffle; zinc ion binding

ENST00000594824:

metal ion binding

ENST00000397274,
ENST00000595618,
ENST00000594824,
ENST00000595641:

cytoplasm; protein binding

ENST00000598419,
ENST00000597073,
ENST00000594824,
ENST00000602177,
ENST00000595641:

metabolic process; positive regulation of GTPase activity

ENST00000397274,
ENST00000595618,
ENST00000598419,
ENST00000597073,
ENST00000594971,
ENST00000594824,
ENST00000602177,
ENST00000595641:

motor activity

ENST00000397274,
ENST00000595618:

ADP binding; ATPase activity; Rho GTPase activator activity; Rho protein signal transduction; actin binding; actin cytoskeleton; actin filament-based movement; calmodulin binding; cell cortex; cytosol; filamentous actin; membrane; microfilament motor activity; perinuclear region of cytoplasm; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction

Phenotypes observed:

Observed phenotypes (?): These terms represent the phenotypic classes observed following the suppression of the expression of the selected gene across independent screens	Assigned ontology terms (?): These terms represent the cellular phenotype ontology terms assigned to the observed phenotypes	Screen (?) Screen ID link to additional information available for each study and screen	Reagent ID (?) Each identifier represents a reagent that was used in a particular screen to suppress the expression of its target gene and for which a phenotype has been observed. The reagents listed here uniquely map to their target gene. The reagent ID displayed is the SysMicro internal ID
			AMBN10013062	AMBN10013063	AMBN10013064	DHARM0003889
Cell death	Cell death	M1_SyM_1			0.66
Dynamic changes	Increased variability of nuclear shape in population synonyms: Variable cell shape	M1_SyM_1	0.5
Impaired cell migration with increased protrusive activity	Impaired cell migration Increased substrate-dependent cell migration, cell extension synonyms: Increased protrusive activity	P2_SyM_1				1
Mild inhibition of secretion	Mild decrease in rate of protein secretion synonyms: Mild inhibition of protein secretion	E1_SyM_1		1
All genes with the same set of phenotypes (number of genes / number of reagents):		phenotype view ontology view	539 / 560 Phenotype set for these genes/reagents: — Dynamic changes 539 / 560 Ontology set for these genes/reagents: — Increased variability of nuclear shape in population	2136 / 2271 Phenotype set for these genes/reagents: — Mild inhibition of secretion 2136 / 2271 Ontology set for these genes/reagents: — Mild decrease in rate of protein secretion	493 / 511 Phenotype set for these genes/reagents: — Cell death 493 / 511 Ontology set for these genes/reagents: — Cell death	41 / 46 Phenotype set for these genes/reagents: — Impaired cell migration with increased protrusive activity 41 / 46 Ontology set for these genes/reagents: — Impaired cell migration — Increased substrate-dependent cell migration, cell extension

1 .. 0.5

— evidence (reproducibility)

Reagents with no phenotype:

Reagents, targeting this gene, but with no phenotype revealed (or revealed with low evidence) for the following screens:

Reagent	Screen ID	Study Title	Screen type
AMBN10013062	B1_SyM_1	BZH_SH4-mCherry-GFP	Primary
AMBN10013063	B1_SyM_1	BZH_SH4-mCherry-GFP	Primary
AMBN10013063	M1_SyM_1	Mitocheck	Primary
AMBN10013064	B1_SyM_1	BZH_SH4-mCherry-GFP	Primary

Cellular Phenotype Database

Gene summary: MYO9B