Gene summary: sequence, alignment information, cellular phenotypes observed

Gene summary: DGKD

Gene information:

Synonyms:: DGKdelta, KIAA0145

Gene description:: diacylglycerol kinase, delta 130kDa [Source:HGNC Symbol;Acc:HGNC:2851]

Ensembl ID:: ENSG00000077044

Protein domains: (provided by InterPro)

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Gene Ontology:

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Phenotypes observed:

Observed phenotypes (?): These terms represent the phenotypic classes observed following the suppression of the expression of the selected gene across independent screens	Assigned ontology terms (?): These terms represent the cellular phenotype ontology terms assigned to the observed phenotypes	Screen (?) Screen ID link to additional information available for each study and screen	Reagent ID (?) Each identifier represents a reagent that was used in a particular screen to suppress the expression of its target gene and for which a phenotype has been observed. The reagents listed here uniquely map to their target gene. The reagent ID displayed is the SysMicro internal ID
			AMBN10001905	DHARM0014321
Increased proliferation	Proliferating cells synonyms: High cell number in population Increased proliferation	M1_SyM_1	0.66
Other phenotype	: Terms is not assigned	C1_SyM_1		1
Strong inhibition of secretion	Strong decrease in rate of protein secretion synonyms: Strong inhibition of protein secretion	E1_SyM_1	1
All genes with the same set of phenotypes (number of genes / number of reagents):		phenotype view ontology view	79 / 26 Phenotype set for these genes/reagents: — Increased proliferation — Strong inhibition of secretion 79 / 26 Ontology set for these genes/reagents: — Proliferating cells — Strong decrease in rate of protein secretion	697 / 751 Phenotype set for these genes/reagents: — Other phenotype 697 / 751 Ontology set for these genes/reagents: : Terms is not assigned

1 .. 0.5

— evidence (reproducibility)

Not unique targeting:

List of reagents also targeting this gene, but not uniquely (?)

Screen ID	Study Title	Screen type	Reagent
E1_SyM_1	EMBL-secretion screen	Primary	AMBN10001904

Reagents with no phenotype:

Reagents, targeting this gene, but with no phenotype revealed (or revealed with low evidence) for the following screens:

Reagent	Screen ID	Study Title	Screen type
AMBN10001903	B1_SyM_1	BZH_SH4-mCherry-GFP	Primary
AMBN10001903	M1_SyM_1	Mitocheck	Primary
AMBN10001904	B1_SyM_1	BZH_SH4-mCherry-GFP	Primary
AMBN10001904	M1_SyM_1	Mitocheck	Primary
AMBN10001905	B1_SyM_1	BZH_SH4-mCherry-GFP	Primary
AMBN10049320	B1_SyM_1	BZH_SH4-mCherry-GFP	Primary
AMBN10049844	B1_SyM_1	BZH_SH4-mCherry-GFP	Primary
DHARM0014321	P2_SyM_1	Phagokinetic track	Primary

Cellular Phenotype Database

Gene summary: DGKD