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CHEBI:41879 - dexamethasone
| Formula | C22H29FO5 |
| Net Charge | 0 |
| Average Mass | 392.467 |
| Monoisotopic Mass | 392.19990 |
| SMILES | [H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@@]21C |
| InChI | InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1 |
| InChIKey | UREBDLICKHMUKA-CXSFZGCWSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| Biological Roles: | antimalarial A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human. antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. antithyroid drug A drug used to treat hyperthyroidism by reducing the excessive production of thyroid hormones. antiviral agent A substance that destroys or inhibits replication of viruses. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. adrenergic agent Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter. antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. hormone Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds. |
| Applications: | antimalarial A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human. antithyroid drug A drug used to treat hyperthyroidism by reducing the excessive production of thyroid hormones. anti-inflammatory drug A substance that reduces or suppresses inflammation. hepatoprotective agent Any compound that is able to prevent damage to the liver. anti-anaemic agent A compound which increases either the number of red cells or the amount of haemoglobin in the blood. anti-inflammatory agent Any compound that has anti-inflammatory effects. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. antirheumatic drug A drug used to treat rheumatoid arthritis. antifibrotic agent Any agent which acts to reduce fibrosis. anti-asthmatic agent Any compound that has anti-asthmatic effects. gastrointestinal drug A drug used for its effects on the gastrointestinal system, e.g. controlling gastric acidity, regulating gastrointestinal motility and water flow, and improving digestion. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. gout suppressant A drug that increases uric acid excretion by the kidney (uricosuric drug), decreases uric acid production (antihyperuricemic), or alleviates the pain and inflammation of acute attacks of gout. anti-allergic agent A drug used to treat allergic reactions. antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. anti-ulcer drug One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract. renoprotective agent Any compound that is able to prevent damage to the kidneys. vulnerary A drug used in treating and healing of wounds. adrenergic agent Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter. antiparasitic agent A substance used to treat or prevent parasitic infections. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases. antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases. antiglaucoma drug Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye. antipsoriatic A drug used to treat psoriasis. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. nasal decongestant A drug used to relieve nasal congestion in the upper respiratory tract. antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| dexamethasone (CHEBI:41879) has parent hydride pregnane (CHEBI:8386) |
| dexamethasone (CHEBI:41879) has role adrenergic agent (CHEBI:37962) |
| dexamethasone (CHEBI:41879) has role analgesic (CHEBI:35480) |
| dexamethasone (CHEBI:41879) has role anti-allergic agent (CHEBI:50857) |
| dexamethasone (CHEBI:41879) has role anti-anaemic agent (CHEBI:75835) |
| dexamethasone (CHEBI:41879) has role anti-asthmatic agent (CHEBI:65023) |
| dexamethasone (CHEBI:41879) has role anti-inflammatory agent (CHEBI:67079) |
| dexamethasone (CHEBI:41879) has role anti-inflammatory drug (CHEBI:35472) |
| dexamethasone (CHEBI:41879) has role anti-ulcer drug (CHEBI:49201) |
| dexamethasone (CHEBI:41879) has role antibacterial agent (CHEBI:33282) |
| dexamethasone (CHEBI:41879) has role antiemetic (CHEBI:50919) |
| dexamethasone (CHEBI:41879) has role antifibrotic agent (CHEBI:233423) |
| dexamethasone (CHEBI:41879) has role antifungal agent (CHEBI:35718) |
| dexamethasone (CHEBI:41879) has role antiglaucoma drug (CHEBI:39456) |
| dexamethasone (CHEBI:41879) has role antihypertensive agent (CHEBI:35674) |
| dexamethasone (CHEBI:41879) has role antiinfective agent (CHEBI:35441) |
| dexamethasone (CHEBI:41879) has role antimalarial (CHEBI:38068) |
| dexamethasone (CHEBI:41879) has role antimicrobial agent (CHEBI:33281) |
| dexamethasone (CHEBI:41879) has role antineoplastic agent (CHEBI:35610) |
| dexamethasone (CHEBI:41879) has role antiparasitic agent (CHEBI:35442) |
| dexamethasone (CHEBI:41879) has role antipsoriatic (CHEBI:50748) |
| dexamethasone (CHEBI:41879) has role antirheumatic drug (CHEBI:35842) |
| dexamethasone (CHEBI:41879) has role antithyroid drug (CHEBI:50671) |
| dexamethasone (CHEBI:41879) has role antitubercular agent (CHEBI:33231) |
| dexamethasone (CHEBI:41879) has role antiviral agent (CHEBI:22587) |
| dexamethasone (CHEBI:41879) has role cardiovascular drug (CHEBI:35554) |
| dexamethasone (CHEBI:41879) has role dermatologic drug (CHEBI:50177) |
| dexamethasone (CHEBI:41879) has role environmental contaminant (CHEBI:78298) |
| dexamethasone (CHEBI:41879) has role gastrointestinal drug (CHEBI:55324) |
| dexamethasone (CHEBI:41879) has role gout suppressant (CHEBI:35845) |
| dexamethasone (CHEBI:41879) has role hepatoprotective agent (CHEBI:62868) |
| dexamethasone (CHEBI:41879) has role immunosuppressive agent (CHEBI:35705) |
| dexamethasone (CHEBI:41879) has role immunosuppressive agent (CHEBI:35705) |
| dexamethasone (CHEBI:41879) has role nasal decongestant (CHEBI:77715) |
| dexamethasone (CHEBI:41879) has role ophthalmology drug (CHEBI:66981) |
| dexamethasone (CHEBI:41879) has role renoprotective agent (CHEBI:231911) |
| dexamethasone (CHEBI:41879) has role vulnerary (CHEBI:73336) |
| dexamethasone (CHEBI:41879) has role xenobiotic (CHEBI:35703) |
| dexamethasone (CHEBI:41879) is a 11β-hydroxy steroid (CHEBI:35346) |
| dexamethasone (CHEBI:41879) is a 17α-hydroxy steroid (CHEBI:35342) |
| dexamethasone (CHEBI:41879) is a 20-oxo steroid (CHEBI:36885) |
| dexamethasone (CHEBI:41879) is a 21-hydroxy steroid (CHEBI:35344) |
| dexamethasone (CHEBI:41879) is a 3-oxo-Δ1,Δ4-steroid (CHEBI:77166) |
| dexamethasone (CHEBI:41879) is a fluorinated steroid (CHEBI:50830) |
| dexamethasone (CHEBI:41879) is a glucocorticoid (CHEBI:24261) |
| Incoming Relation(s) |
| dexamethasone phosphate (CHEBI:68637) has functional parent dexamethasone (CHEBI:41879) |
| dexamethasone sodium m-sulfobenzoate (CHEBI:32132) has functional parent dexamethasone (CHEBI:41879) |
| IUPAC Name |
|---|
| 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione |
| INNs | Source |
|---|---|
| dexametasona | WHO MedNet |
| dexamethasone | WHO MedNet |
| dexaméthasone | WHO MedNet |
| dexamethasonum | WHO MedNet |
| Synonyms | Source |
|---|---|
| (11β,16α)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione | ChemIDplus |
| 16α-methyl-9α-fluoro-1-dehydrocortisol | NIST Chemistry WebBook |
| 1-dehydro-16α-methyl-9α-fluorohydrocortisone | NIST Chemistry WebBook |
| 9α-fluoro-16α-methylprednisolone | NIST Chemistry WebBook |
| Dexamethasone | KEGG DRUG |
| Dexamethasone valerate | ChEMBL |
| Brand Names | Source |
|---|---|
| Aeroseb-Dex | ChemIDplus |
| Auxiron | ChemIDplus |
| Azium | ChemIDplus |
| Calonat | ChemIDplus |
| Corson | ChEBI |
| Cortisumman | ChemIDplus |
| UniProt Name | Source |
|---|---|
| dexamethasone | UniProt |
| Citations |
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