CHEBI:74460 - 5-chloro-7-iodoquinolin-8-ol

ChEBI IDCHEBI:74460
ChEBI Name5-chloro-7-iodoquinolin-8-ol
Stars
DefinitionA monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Last Modified12 November 2020
SubmitterGareth Owen
DownloadsMolfile
FormulaC9H5ClINO
Net Charge0
Average Mass305.502
Monoisotopic Mass304.91044
SMILESOc1c(I)cc(Cl)c2cccnc12
InChIInChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
InChIKeyQCDFBFJGMNKBDO-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Roles:
chelator  A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate.
copper chelator  A chelator that is any compound containing a ligand (typically organic) which is able to form a bond to a central copper atom at two or more points.
Biological Roles:
antimicrobial agent  A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
antiprotozoal drug  Any antimicrobial drug which is used to treat or prevent protozoal infections.
antifungal agent  An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
antibacterial agent  A substance (or active part thereof) that kills or slows the growth of bacteria.
Applications:
antiprotozoal drug  Any antimicrobial drug which is used to treat or prevent protozoal infections.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antibacterial agent (CHEBI:33282)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antifungal agent (CHEBI:35718)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antimicrobial agent (CHEBI:33281)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antineoplastic agent (CHEBI:35610)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antiprotozoal drug (CHEBI:35820)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role chelator (CHEBI:38161)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role copper chelator (CHEBI:166831)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) is a monohydroxyquinoline (CHEBI:38775)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) is a organochlorine compound (CHEBI:36683)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) is a organoiodine compound (CHEBI:37142)
IUPAC Name 
5-chloro-7-iodoquinolin-8-ol
INNs  Source
clioquinolChemIDplus
clioquinolWHO MedNet
clioquinolWHO MedNet
clioquinolumChemIDplus
Synonyms  Source
5-chloro-8-hydroxy-7-iodoquinolineChemIDplus
7-iodo-5-chloroxineChemIDplus
5-Chlor-7-jod-8-hydroxy-chinolinChemIDplus
5-chloro-7-iodo-8-hydroxyquinolineChemIDplus
7-iodo-5-chloro-8-hydroxyquinolineChemIDplus
iodochlorohydroxyquinChemIDplus
Manual XrefsDatabases
DB04815DrugBank
D03538KEGG DRUG
CQLPDBeChem
DE117767Patent
US641491Patent
ClioquinolWikipedia
LSM-2186LINCS
681DrugCentral
Registry NumbersSources
Reaxys:153637Reaxys
CAS:130-26-7ChemIDplus
CAS:130-26-7NIST Chemistry WebBook
Citations