EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:74460 - 5-chloro-7-iodoquinolin-8-ol

Default Structure
ChEBI IDCHEBI:74460
ChEBI Name5-chloro-7-iodoquinolin-8-ol
Stars
DefinitionA monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Last Modified12 November 2020
SubmitterGareth Owen
DownloadsMolfile
FormulaC9H5ClINO
Net Charge0
Average Mass305.502
Monoisotopic Mass304.91044
SMILESOc1c(I)cc(Cl)c2cccnc12
InChIInChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
InChIKeyQCDFBFJGMNKBDO-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Roles:
copper chelator  A chelator that is any compound containing a ligand (typically organic) which is able to form a bond to a central copper atom at two or more points.
chelator  A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate.
Biological Roles:
antifungal agent  An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
antibacterial agent  A substance (or active part thereof) that kills or slows the growth of bacteria.
antiprotozoal drug  Any antimicrobial drug which is used to treat or prevent protozoal infections.
antimicrobial agent  A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
antiprotozoal drug  Any antimicrobial drug which is used to treat or prevent protozoal infections.
ChEBI Ontology
Outgoing Relation(s)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antibacterial agent (CHEBI:33282)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antifungal agent (CHEBI:35718)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antimicrobial agent (CHEBI:33281)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antineoplastic agent (CHEBI:35610)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role antiprotozoal drug (CHEBI:35820)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role chelator (CHEBI:38161)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) has role copper chelator (CHEBI:166831)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) is a monohydroxyquinoline (CHEBI:38775)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) is a organochlorine compound (CHEBI:36683)
5-chloro-7-iodoquinolin-8-ol (CHEBI:74460) is a organoiodine compound (CHEBI:37142)
IUPAC Name 
5-chloro-7-iodoquinolin-8-ol
INNs  Source
clioquinolWHO MedNet
clioquinolWHO MedNet
clioquinolChemIDplus
clioquinolumChemIDplus
Synonyms  Source
5-Chlor-7-jod-8-hydroxy-chinolinChemIDplus
5-chloro-7-iodo-8-hydroxyquinolineChemIDplus
5-chloro-7-iodo-8-quinolinolChemIDplus
5-chloro-8-hydroxy-7-iodoquinolineChemIDplus
7-iodo-5-chloro-8-hydroxyquinolineChemIDplus
7-iodo-5-chloroxineChemIDplus
Manual XrefsDatabases
681DrugCentral
ClioquinolWikipedia
CQLPDBeChem
D03538KEGG DRUG
DB04815DrugBank
DE117767Patent
LSM-2186LINCS
US641491Patent
Registry NumbersSources
Reaxys:153637Reaxys
CAS:130-26-7NIST Chemistry WebBook
CAS:130-26-7ChemIDplus
Citations