triflupromazine (CHEBI:9711)

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CHEBI:9711 - triflupromazine

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ChEBI ID	CHEBI:9711
ChEBI Name	triflupromazine
Stars
Definition	A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(dimethylamino)propyl group at the N-10 position.
Last Modified	23 April 2020
Downloads	Molfile

Formula	C18H19F3N2S
Net Charge	0
Average Mass	352.425
Monoisotopic Mass	352.12210
SMILES	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21
InChI	InChI=1S/C18H19F3N2S/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3
InChIKey	XSCGXQMFQXDFCW-UHFFFAOYSA-N

Wikipedia

Roles Classification

Chemical Role:	Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:	anticoronaviral agent Any antiviral agent which inhibits the activity of coronaviruses. dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
Applications:	antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. first generation antipsychotic Antipsychotic drugs which can have different modes of action but which tend to be more likely than second generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements; such body movements can become permanent even after treatment has ceased. dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.

ChEBI Ontology

Outgoing Relation(s)
	triflupromazine (CHEBI:9711) has parent hydride 10H-phenothiazine (CHEBI:37931)
	triflupromazine (CHEBI:9711) has role anticoronaviral agent (CHEBI:149553)
	triflupromazine (CHEBI:9711) has role antiemetic (CHEBI:50919)
	triflupromazine (CHEBI:9711) has role dopaminergic antagonist (CHEBI:48561)
	triflupromazine (CHEBI:9711) has role first generation antipsychotic (CHEBI:65190)
	triflupromazine (CHEBI:9711) is a organofluorine compound (CHEBI:37143)
	triflupromazine (CHEBI:9711) is a phenothiazines (CHEBI:38093)
	triflupromazine (CHEBI:9711) is a tertiary amine (CHEBI:32876)
Incoming Relation(s)
Incoming Relation(s)	triflupromazine hydrochloride (CHEBI:9712) has part triflupromazine (CHEBI:9711)

IUPAC Name
N,N-dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-amine

INNs	Source
triflupromazine	ChEBI
triflupromazina	ChEBI
triflupromazinum	ChEBI

Synonyms	Source
10-(3-(Dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine	ChemIDplus
2-(Trifluoromethyl)promazine	ChemIDplus
2-Trifluoromethyl-10-(gamma-dimethylaminopropyl)phenothiazine	ChemIDplus
trifluopromazine	ChEBI

Manual Xrefs	Databases
D00390	KEGG DRUG
DB00508	DrugBank
GB813861	Patent
Triflupromazine	Wikipedia
HMDB0014650	HMDB
LSM-3421	LINCS
2742	DrugCentral

Registry Numbers	Sources
Reaxys:335308	Reaxys
CAS:146-54-3	ChemIDplus

Citations