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CHEBI:9683 - trichlormethiazide

Default Structure
ChEBI IDCHEBI:9683
ChEBI Nametrichlormethiazide
Stars
DefinitionA benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension.
Last Modified25 May 2018
DownloadsMolfile
FormulaC8H8Cl3N3O4S2
Net Charge0
Average Mass380.662
Monoisotopic Mass378.90218
SMILESNS(=O)(=O)c1cc2c(cc1Cl)NC(C(Cl)Cl)NS2(=O)=O
InChIInChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)
InChIKeyLMJSLTNSBFUCMU-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
antimicrobial agent  A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
Applications:
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
diuretic  An agent that promotes the excretion of urine through its effects on kidney function.
cardiovascular drug  A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
ChEBI Ontology
Outgoing Relation(s)
trichlormethiazide (CHEBI:9683) has role antihypertensive agent (CHEBI:35674)
trichlormethiazide (CHEBI:9683) has role cardiovascular drug (CHEBI:35554)
trichlormethiazide (CHEBI:9683) has role diuretic (CHEBI:35498)
trichlormethiazide (CHEBI:9683) is a benzothiadiazine (CHEBI:50265)
trichlormethiazide (CHEBI:9683) is a sulfonamide antibiotic (CHEBI:87228)
IUPAC Name 
6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
INNs  Source
trichlormethiazideChemIDplus
trichlormethiazidumChemIDplus
triclormetiazidaChemIDplus
Synonyms  Source
hydrotrichlorothiazideChemIDplus
NSC-61560ChEMBL
Brand Names  Source
MetahydrinChEMBL
NaquaChEMBL
TrichlorexChEMBL
TrichlormasChEMBL
Trichlormethiazide component of metatensinChEMBL
Trichlormethiazide component of naquivalChEMBL
Manual XrefsDatabases
2733DrugCentral
C07767KEGG COMPOUND
D00658KEGG DRUG
DB01021DrugBank
LSM-4383LINCS
TrichlormethiazideWikipedia
Registry NumbersSources
CAS:133-67-5ChemIDplus
CAS:133-67-5KEGG COMPOUND
Citations